Review
Neurosciences
Olesja Bondarenko, Mart Saarma
Summary: Neurotrophic factors (NTFs) are essential for neuronal development and survival but face challenges in delivery to the brain due to the blood-brain barrier. Nanoparticles (NPs) show promise in stabilizing and transporting NTFs across the BBB, offering a potential solution to systemic delivery.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Cell Biology
Rossella Rotondo, Stefania Proietti, Marzia Perluigi, Elvira Padua, Fabrizio Stocchi, Massimo Fini, Vilberto Stocchi, Daniele Volpe, Maria Francesca De Pandis
Summary: The benefits of physical therapy on motor and non-motor symptoms in Parkinson's disease patients are supported by consistent evidence, with neurotrophic factors (NFs) playing a key role in neuroplasticity. However, the lack of standardized exercise training and methodological flaws in clinical trials have limited the evidence for exercise-induced changes in NFs concentration.
AGEING RESEARCH REVIEWS
(2023)
Article
Environmental Sciences
Agnieszka Gorzkowska, Joanna Cholewa, Jaroslaw Cholewa, Aleksander Wilk, Aleksandra Klimkowicz-Mrowiec
Summary: Apathy is a common neuropsychiatric symptom in Parkinson's disease, with a high prevalence rate. Some risk factors for apathy may be clinically modifiable.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Medicine, Research & Experimental
Mahmoud A. Alomari, Hanan Khalil, Omar F. Khabour, Karem H. Alzoubi
Summary: The study revealed a relationship between BDNF and lipid profile, suggesting the importance of BDNF for lipid metabolism in patients with Parkinson's disease.
Article
Clinical Neurology
Yixian Huang, Caili Huang, Qilin Zhang, Wenqi Wu, Jiawei Sun
Summary: Lower serum BDNF levels may serve as a useful clinical biomarker for depression in PD patients, particularly in those with depression. Levels of BDNF were significantly associated with motor severity and gender in depressed PD patients, with women showing a stronger correlation.
JOURNAL OF NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Kuo-Jen Wu, Tsai-Wei Hung, Yu-Syuan Wang, Yun-Hsiang Chen, Eun-Kyung Bae, Seong-Jin Yu
Summary: Saposin and its precursor prosaposin are endogenous proteins with neurotrophic and anti-apoptotic properties. This study found that PS18 has neuroprotective effects in cellular and animal models of Parkinson's disease, possibly through anti-endoplasmic reticulum stress mechanisms.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Yaping Chu, Jeffrey H. Kordower
Summary: This study performed post-mortem studies on two patients with advanced Parkinson's disease to verify the long-term effects of the trophic factor neurturin. The results showed persistent neurturin expression and bioactivity following gene delivery, which could enhance dopamine neuron function.
MOVEMENT DISORDERS
(2023)
Review
Cell Biology
Theodora Mourtzi, Ilias Kazanis
Summary: Parkinson's disease is a common neurodegenerative disorder with no effective treatment. Cell replacement therapy shows promise in treating Parkinson's disease, but there are still significant limitations and questions to be addressed.
NEURAL REGENERATION RESEARCH
(2022)
Article
Clinical Neurology
Yi-xian Huang, Qi-lin Zhang, Cai-li Huang, Wen-qi Wu, Jia-wei Sun
Summary: The study found a significantly higher prevalence of RLS in PD patients, with lower BDNF levels in PD patients with RLS compared to other groups, and a negative correlation between BDNF levels and RLS severity.
FRONTIERS IN NEUROLOGY
(2021)
Article
Food Science & Technology
Tian Jin, Yong Zhang, Benson O. A. Botchway, Jian Zhang, Ruihua Fan, Yufeng Zhang, Xuehong Liu
Summary: Curcumin has neuroprotective effects in Parkinson's disease by activating the BDNF and PI3K/Akt signaling pathways, thereby delaying the progression of the disease.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Cell Biology
Tamara Andrea Alarcon, Sarah Martins Presti-Silva, Ana Paula Toniato Simoes, Fabiola Mara Ribeiro, Rita Gomes Wanderley Pires
Summary: Parkinson's disease is a common movement disorder affecting 1% of people over 60 years old. It is characterized by motor symptoms and the loss of dopaminergic neurons. In addition to neuronal loss, the disease is also characterized by the accumulation of alpha-synuclein protein aggregates. Environmental enrichment, including exercise and cognitive stimulus, has been studied as a potential treatment strategy for Parkinson's disease. It can promote neurogenesis and change gene expression, as well as modulate neurotransmission, providing neuroprotection in animal models.
NEURAL REGENERATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Ava Nasrolahi, Fatemeh Javaherforooshzadeh, Mohsen Jafarzadeh-Gharehziaaddin, Javad Mahmoudi, Khadijeh Dizaji Asl, Zahra Shabani
Summary: NTFs are considered as new and promising candidates for treating AD and AD-associated cognitive impairment, with potential to protect and treat neurodegenerative diseases.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Clinical Neurology
D. Luke Fischer, Peggy Auinger, John L. Goudreau, Katrina L. Paumier, Allyson Cole-Strauss, Christopher J. Kemp, Jack W. Lipton, Caryl E. Sortwell
Summary: This study found that several SNPs in the BDNF gene are associated with the rate of disease progression in Parkinson's disease. Specific genotypes may be related to a slower progression of the disease in early-stage patients who are not receiving medication.
FRONTIERS IN NEUROLOGY
(2022)
Review
Pharmacology & Pharmacy
Ruben Del Campo-Montoya, Maria-Rosario Luquin, Elena Puerta, Elisa Garbayo, Maria J. Blanco-Prieto
Summary: This article discusses the potential application of hydrogel-based therapies for Parkinson's disease. It addresses the desirable composition and mechanical properties of these therapies for brain application, as well as the preclinical research available with hydrogels in Parkinson's disease. Lastly, translational and manufacturing challenges are presented.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Biology
Andrea Antonosante, Vanessa Castelli, Martina Sette, Margherita Alfonsetti, Mariano Catanesi, Elisabetta Benedetti, Matteo Ardini, Annamaria Cimini, Michele d'Angelo
Summary: The study suggests that PPAR beta/delta antagonist has neuroprotective effects on Parkinson's disease by reducing apoptosis, oxidative stress, and improving mitochondrial function. The animal model experiments confirmed these findings.
BIOLOGICAL RESEARCH
(2023)
Article
Neurosciences
Valentina Castiglioni, Andrea Faedo, Marco Onorati, Vittoria Dickinson Bocchi, Zhen Li, Raffaele Iennaco, Romina Vuono, Gaetano P. Bulfamante, Luca Muzio, Gianvito Martino, Nenad Sestan, Roger A. Barker, Elena Cattaneo
Article
Immunology
C. H. Williams-Gray, R. S. Wijeyekoon, K. M. Scott, S. Hayat, R. A. Barker, J. L. Jones
JOURNAL OF NEUROINFLAMMATION
(2018)
Article
Clinical Neurology
Lucy M. Collins, Caroline H. Williams-Gray, Elizabeth Morris, Patrick Deegan, Timothy M. Cox, Roger A. Barker
JOURNAL OF NEUROLOGY
(2018)
Article
Clinical Neurology
Thais Minett, Li Su, Elijah Mak, Guy Williams, Michael Firbank, Rachael A. Lawson, Alison J. Yarnall, Gordon W. Duncan, Adrian M. Owen, Tien K. Khoo, David J. Brooks, James B. Rowe, Roger A. Barker, David Burn, John T. O'Brien
JOURNAL OF NEUROLOGY
(2018)
Article
Clinical Neurology
Naveed Malek, Rimona S. Weil, Catherine Bresner, Michael A. Lawton, Katherine A. Grosset, Manuela Tan, Nin Bajaj, Roger A. Barker, David J. Burn, Thomas Foltynie, John Hardy, Nicholas W. Wood, Yoav Ben-Shlomo, Nigel W. Williams, Donald G. Grosset, Huw R. Morris
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2018)
Correction
Multidisciplinary Sciences
Alba Di Pardo, Enrico Amico, Abdul Basit, Andrea Armirotti, Piyush Joshi, M. Diana Neely, Romina Vuono, Salvatore Castaldo, Anna F. Digilio, Francesco Scalabri, Giuseppe Pepe, Francesca Elifani, Michele Madonna, Se Kyoo Jeong, Bu-Mahn Park, Maurizio D'Esposito, Aaron B. Bowman, Roger A. Barker, Vittorio Maglione
SCIENTIFIC REPORTS
(2018)
Editorial Material
Neurosciences
Bastiaan R. Bloem, Jan H. L. Ypinga, Allison Willis, Colleen G. Canning, Roger A. Barker, Marten Munneke, Nienke M. De Vries
JOURNAL OF PARKINSONS DISEASE
(2018)
Article
Neurosciences
Benjamin J. Clegg, Gordon W. Duncan, Tien K. Khoo, Roger A. Barker, David J. Burn, Alison J. Yarnall, Rachael A. Lawson
JOURNAL OF PARKINSONS DISEASE
(2018)
Article
Multidisciplinary Sciences
Shelby Shrigley, Karolina Pircs, Roger A. Barker, Malin Parmar, Janelle Drouin-Ouellet
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2018)
Article
Neurosciences
Julia C. Greenland, Caroline H. Williams-Gray, Roger A. Barker
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Article
Clinical Neurology
Mayke Oosterloo, Emilia Bijlsma, Sander van Kuijk, Floor Minkes, Raymund Roos, C. E. M. de Die-Smulders
PARKINSONISM & RELATED DISORDERS
(2019)
Editorial Material
Clinical Neurology
Roger Barker, Sarah L. Mason
Article
Neurosciences
Jerome Lamontagne-Proulx, Isabelle St-Amour, Richard Labib, Jeremie Pilon, Helena L. Denis, Nathalie Cloutier, Florence Roux-Dalvai, Antony T. Vincent, Sarah L. Mason, Caroline Williams-Gray, Anne-Claire Duchez, Arnaud Droit, Steve Lacroix, Nicolas Dupre, Melanie Langlois, Sylvain Chouinard, Michel Panisset, Roger A. Barker, Eric Boilard, Francesca Cicchetti
NEUROBIOLOGY OF DISEASE
(2019)
Article
Biochemistry & Molecular Biology
Roger A. Barker, Krista Farrell, Natalie Valle Guzman, Xiaoling He, Stanley E. Lazic, Sarah Moore, Robert Morris, Pamela Tyers, Ruwani Wijeyekoon, Danielle Daft, Sam Hewitt, Viswas Dayal, Thomas Foltynie, Zinovia Kefalopoulou, Philipp Mahlknecht, Nick P. Lao-Kaim, Paola Piccini, Hjalmar Bjartmarz, Anders Bjorklund, Olle Lindvall, Jenny Nelander-Wahlestedt, Malin Parmar, Gesine Paul, Hakan Widner, Alistair Church, Stephen Dunnett, Kathryn Peall, Anne Rosser, Jean Marc Gurruchaga, Stephane Palfi, Tobias Piroth, Christian Winkler
Article
Public, Environmental & Occupational Health
Valentina Gallo, Paolo Vineis, Mariagrazia Cancellieri, Paolo Chiodini, Roger A. Barker, Carol Brayne, Neil Pearce, Roel Vermeulen, Salvatore Panico, Bas Bueno-de-Mesquita, Nicola Vanacore, Lars Forsgren, Silvia Ramat, Eva Ardanaz, Larraitz Arriola, Jesper Peterson, Oskar Hansson, Diana Gavrila, Carlotta Sacerdote, Sabina Sieri, Tilman Kuehn, Verena A. Katzke, Yvonne T. van der Schouw, Andreas Kyrozis, Giovanna Masala, Amalia Mattiello, Robert Perneczky, Lefkos Middleton, Rodolfo Saracci, Elio Riboli
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2019)