Article
Chemistry, Multidisciplinary
Taslim A. Al-Hilal, Mohammad Anwar Hossain, Ahmed Alobaida, Farzana Alam, Ali Keshavarz, Eva Nozik-Grayck, Kurt R. Stenmark, Nadezhda A. German, Fakhrul Ahsan
Summary: The study developed a hypoxia-activated prodrug of fasudil that selectively suppresses ROCK activity under hypoxic conditions, exhibiting antiproliferative effects on disease-afflicted pulmonary arterial smooth muscle cells and pulmonary arterial endothelial cells. The prodrug has a long plasma half-life and does not affect systemic blood pressure.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Physiology
Chuan Jiang, Ning Dong, Jianli Feng, Maolin Hao
Summary: miR-190 plays a protective role against brain I/R damage by modulating Rho/Rho-kinase signaling.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yosuke Nagai, Keiichiro Matoba, Hideji Yako, Shinji Ohashi, Kensuke Sekiguchi, Etsuko Mitsuyoshi, Kazunori Sango, Daiji Kawanami, Kazunori Utsunomiya, Rimei Nishimura
Summary: The activation of small GTPase Rho and its effector Rho-kinase (ROCK) in the diabetic kidney has been shown to play an important role in the progression of diabetic kidney disease. This study demonstrates that inhibiting the isoform ROCK1 can restore fatty acid oxidation in the glomeruli. The inhibition of ROCK1 optimizes fatty acid utilization and redox balance in mesangial cells through AMPK phosphorylation and induction of PGC-1a, suggesting ROCK1 as a promising therapeutic target for diabetic kidney disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Chengyu Xiang, Yi Yan, Dingguo Zhang
Summary: The study demonstrates that fasudil has a protective effect on doxorubicin-induced nephrotoxicity by inhibiting oxidative stress, DNA damage, apoptosis, and cell senescence through targeting the RhoA/Rho kinase (ROCK) signaling pathway.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Review
Immunology
Anuja Singh, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Vasudevan Mani, Amal M. Alsubayiel, Saurabh Bhatia, Ahmed Al-Harrasi, Simona Bungau
Summary: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by dysregulated inflammatory reactions and T lymphocyte invasion into the joints. Research suggests that the Rho enzyme family and the ROCK regulatory cascade play a role in the pathogenesis of autoimmune diseases, with ROCK activation observed in RA patients and blocking ROCK showing potential for reducing inflammatory cytokines.
INFLAMMOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kemeng Zhao, Pengwei Wang, Xiaoguang Tang, Na Chang, Haonan Shi, Longfei Guo, Bingyi Wang, Pengfei Yang, Tiantian Zhu, Xinghua Zhao
Summary: Stroke is caused by ruptured or blocked cerebral blood vessels and subsequent disruption of brain blood circulation, resulting in rapid neurological deficits. The majority of stroke cases are ischemic strokes. Current treatments for ischemic stroke, such as t-PA thrombolytic therapy and surgical thrombectomy, can paradoxically lead to ischemia-reperfusion injury, exacerbating brain damage. Minocycline, a semi-synthetic tetracycline antibiotic, has demonstrated a wide range of neuroprotective effects independent of its antibacterial activity. In this article, we summarize the mechanisms underlying the protective effects of minocycline against cerebral ischemia-reperfusion injury, including modulation of oxidative stress, inflammatory response, excitotoxicity, programmed cell death, and blood-brain barrier injury. We also discuss the role of minocycline in alleviating stroke-related complications, providing a theoretical basis for its clinical application in cerebral ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Bin Wang, Yongfang Wang, Yan Tan, Jinxia Guo, Haoyuan Chen, Pu-Yeh Wu, Xiaochun Wang, Hui Zhang
Summary: The study evaluated the utility of fasudil in a rat model of contrast-associated acute kidney injury (CA-AKI) and found that it could reduce renal hypoxia, fibrosis, and dysfunction by activating or inhibiting certain signaling pathways. Multiparametric MRI may be a viable noninvasive tool for monitoring CA-AKI pathophysiology during fasudil therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Keiichiro Matoba, Kensuke Sekiguchi, Yosuke Nagai, Yusuke Takeda, Hiroshi Takahashi, Tamotsu Yokota, Kazunori Utsunomiya, Rimei Nishimura
Summary: ROCK plays a critical role in diabetic nephropathy, with its substrate MYPT1 showing increased phosphorylation in affected patients. Analysis of patients with diabetes treated with fasudil revealed a reduction in proteinuria and potential renal protective effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Matteo Haupt, Stefan T. Gerner, Mathias Baehr, Thorsten R. Doeppner
Summary: Despite significant progress in stroke therapy, ischemic stroke still imposes a high socioeconomic burden on industrialized countries. Current treatment paradigms focus on thrombolysis or thrombectomy, which are only suitable for a fraction of patients. Therefore, there is an urgent need for adjuvant therapeutic approaches like neuroprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Yingchun Xiang, Yumiao Niu, Yacong Xie, Shishuo Chen, Feng Zhu, Weida Shen, Ling-Hui Zeng
Summary: The study investigated the phosphorylation levels of the RhoA/Rho kinase pathway in response to KA treatment, and found that KA induces activation of the pathway leading to inhibition of neurite outgrowth. Pretreatment with fasudil reversed this effect, suggesting that inhibiting the RhoA/Rho kinase pathway may be a potential treatment for seizure-induced neurite injury.
BRAIN AND BEHAVIOR
(2021)
Review
Immunology
Lukasz Przykaza
Summary: Common concomitant stroke risk factors such as hypertension, diabetes, and hyperlipidemia exacerbate inflammatory processes during cerebral ischemia/reperfusion, leading to dysfunction of neurovascular units. In-depth basic research on these factors is crucial for the success of future neuroprotection, vasculoprotection, and immunomodulation therapies in stroke.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Qing Wang, Li-Juan Song, Zhi-Bin Ding, Zhi Chai, Jie-Zhong Yu, Bao-Guo Xiao, Cun-Gen Ma
Summary: Ras homolog (Rho)-associated kinases (ROCKs) play a significant role in regulating the damage, survival, axon guidance, and regeneration of neurons. ROCKs are also involved in the development of neurodegenerative diseases and the biological effects of immune and glial cells. ROCKs inhibitors, like fasudil, have been found to attenuate the symptoms and progression of neurodegenerative diseases by inhibiting neuroinflammation, regulating immune imbalance, repairing the blood-brain barrier, and promoting nerve repair and myelin regeneration.
NEURAL REGENERATION RESEARCH
(2022)
Article
Neurosciences
Golnar Taheri, Maryam Sardari, Dirk M. Hermann, Houri Sepehri
Summary: This study investigated whether NMDA receptor blockade with ketamine could protect against the deleterious effects of LPS-induced sepsis-like state in mice with transient cerebral artery occlusion. The results showed that ketamine treatment attenuated the sepsis-associated temperature reduction, reduced neurological deficits, decreased infarct volume, and promoted neuronal survival. Furthermore, ketamine modulated the expression of certain genes involved in immune response.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Andrea Lopez-Lopez, Rita Valenzuela, Ana Isabel Rodriguez-Perez, Maria J. Guerra, Jose Luis Labandeira-Garcia, Ana Munoz
Summary: Statins have been proposed for the treatment of L-DOPA-induced dyskinesia (LID), and their anti-dyskinetic effects may be related to the inhibition of the Ras-ERK pathway. The mechanisms responsible for the anti-LID effect are unclear, but they could involve changes in cholesterol homeostasis and oxidative stress- and inflammation-related mechanisms. Angiotensin II, cholesterol, and Rho-kinase pathways have been found to interact in LID, and their inhibition by specific drugs may attenuate the dyskinetic symptoms.
Article
Medicine, General & Internal
Maria Chondrogianni, Vaia Lambadiari, Aristeidis H. Katsanos, Maria Ioanna Stefanou, Lina Palaiodimou, Alexandros Stavros Triantafyllou, Georgios Karagiannis, Vasileios Konstantakos, Michael Ioakeimidis, Sokratis Triantafyllou, Christina Zompola, Chryssa Liantinioti, Alexandra Pappa, Ioannis Rizos, Konstantinos Voumvourakis, Georgios Tsivgoulis, Eleni Boutati
Summary: Mounting evidence suggests an association between adipokines and inflammation-related atherosclerosis. Omentin, but not vaspin, was found to be correlated with stroke severity and ipsilateral carotid stenosis, potentially serving as a biomarker linked to atherosclerotic plaque presence in patients with acute cerebral ischemia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Giovanni Giurdanella, Carmelina Daniela Anfuso, Melania Olivieri, Gabriella Lupo, Nunzia Caporarello, Chiara M. Eandi, Filippo Drago, Claudio Bucolo, Salvatore Salomone
BIOCHEMICAL PHARMACOLOGY
(2015)
Article
Pharmacology & Pharmacy
Valeria Pittala, Loredana Salerno, Giuseppe Romeo, Maria Angela Siracusa, Maria Nunziata Modica, Giovanni Luca Romano, Salvatore Salomone, Filippo Drago, Claudio Bucolo
EUROPEAN JOURNAL OF PHARMACOLOGY
(2015)
Article
Clinical Neurology
Gian Marco Leggio, Sebastian Alfio Torrisi, Alessandro Castorina, Chiara Bianca Maria Platania, Agata Antonia Rita Impellizzeri, Annamaria Fidilio, Filippo Caraci, Claudio Bucolo, Filippo Drago, Salvatore Salonnone
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2015)
Article
Pharmacology & Pharmacy
Antonio Leonardi, Claudio Bucolo, Filippo Drago, Salvatore Salomone, Rosario Pignatello
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2015)
Article
Pharmacology & Pharmacy
Theophile Godfraind, Salvatore Salomone
FRONTIERS IN PHARMACOLOGY
(2015)
Article
Gastroenterology & Hepatology
Giulia Malaguarnera, Manuela Pennisi, Caterina Gagliano, Marco Vacante, Michele Malaguarnera, Salvatore Salomone, Filippo Drago, Gaetano Bertino, Filippo Caraci, Giuseppe Nunnari, Mariano Malaguarnera
Article
Pharmacology & Pharmacy
Salvatore Salomone, Cateno Piazza, Daniela Cristina Vitale, Francesco Cardi, Barbara Gugliotta, Filippo Drago
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
(2014)
Article
Cell Biology
Giovanni Giurdanella, Giuseppe Montalbano, Florinda Gennuso, Serena Brancati, Debora Lo Furno, Antonio Augello, Claudio Bucolo, Filippo Drago, Salvatore Salomone
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Claudia G. Fresta, Annamaria Fidilio, Giuseppe Caruso, Filippo Caraci, Frank J. Giblin, Gian Marco Leggio, Salvatore Salomone, Filippo Drago, Claudio Bucolo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Clinical Neurology
Loretta Giuliano, Greta Mainieri, Calogero Edoardo Cicero, Giulia Battaglia, Antonella Guccione, Salvatore Salomone, Filippo Drago, Alessandra Nicoletti, Vito Sofia, Mario Zappia
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2020)
Article
Health Care Sciences & Services
Giovanna Morello, Giulia Gentile, Rossella Spataro, Antonio Gianmaria Spampinato, Maria Guarnaccia, Salvatore Salomone, Vincenzo La Bella, Francesca Luisa Conforti, Sebastiano Cavallaro
JOURNAL OF PERSONALIZED MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Veronica Zingales, Sebastiano Alfio Torrisi, Gian Marco Leggio, Claudio Bucolo, Filippo Drago, Salvatore Salomone
Summary: D3R stimulation in mouse aorta specifically induces vasoconstriction, while D2R stimulation does not. This is in line with the higher expression level of D3R in the aorta. Residual vasoconstriction elicited by high concentration D3R agonist in D3R(-)/(-) or in the presence of D3R antagonist is likely unrelated to dopamine receptors.
Article
Biochemistry & Molecular Biology
Oriana Maria Maurel, Sebastiano Alfio Torrisi, Cristina Barbagallo, Michele Purrello, Salvatore Salomone, Filippo Drago, Marco Ragusa, Gian Marco Leggio
Summary: Our study found that the expression of miRNAs in different brain areas is associated with susceptibility/resilience to PTSD. Changes in specific miRNAs may influence the transcription levels of FKBP5 and BDNF, and show a linear correlation with stress-induced behavioral phenotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Alessandro Rodolico, Carmen Concerto, Alessia Ciancio, Spyridon Siafis, Laura Fusar-Poli, Carla Romano, Elisa Scavo, Antonino Petralia, Salvatore Salomone, Maria Signorelli, Stefan Leucht, Eugenio Aguglia
Summary: The study translated the GASS scale into Italian to assess the validity and feasibility of evaluating side effects reported by patients receiving antipsychotic drugs. The GASS showed modest structural validity and good internal consistency, but was not optimal in identifying side effects.
Article
Ophthalmology
Giulia Malaguarnera, Caterina Gagliano, Salvatore Salomone, Maria Giordano, Claudio Bucolo, Antonino Pappalardo, Filippo Drago, Filippo Caraci, Teresio Avitabile, Massimo Motta
CLINICAL OPHTHALMOLOGY
(2015)
