Protein kinase C inhibitors: a patent review (2008 – 2009)

A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer

(2012) Cynthia X. Ma et al.   BREAST CANCER RESEARCH AND TREATMENT

Protein kinase Cα/β inhibitor Gö6976 promotes PC12 cell adhesion and spreading through membrane recruitment and activation of protein kinase Cδ

(2012) Sung Youn Jung et al.   EXPERIMENTAL CELL RESEARCH

Protein kinase C βII in diabetic complications: survey of structural, biological and computational studies

(2012) M Elizabeth Sobhia et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

6-Hydroxydopamine upregulates iron regulatory protein 1 by activating certain protein kinase C isoforms in the dopaminergic MES23.5 cell line

(2012) Wenjie Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Staurosporine Induces Necroptotic Cell Death under Caspase-Compromised Conditions in U937 Cells

(2012) Zsuzsanna A. Dunai et al.   PLoS One

ORAL PROTEIN KINASE C β INHIBITION USING RUBOXISTAURIN

(2011) Lloyd Paul Aiello et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies

(2010) Paula M. Fracasso et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Inhibition of Protein Kinase C–β by Ruboxistaurin Preserves Cardiac Function and Reduces Extracellular Matrix Production in Diabetic Cardiomyopathy

(2009) Kim A. Connelly et al.   Circulation-Heart Failure

Protein kinase C is inhibited by bisphosphonates in prostate cancer PC-3 cells

(2009) Yoshiki Tatsuda et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Enzastaurin (LY317615), a Protein Kinase C Beta Selective Inhibitor, Enhances Antiangiogenic Effect of Radiation

(2009) Christopher D. Willey et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

PKC-alpha inhibitor MT477 slows tumor growth with minimal toxicity in in vivo model of non-Ras-mutated cancer via induction of apoptosis

(2009) Piotr Jasinski et al.   INVESTIGATIONAL NEW DRUGS

Discovery of 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a Potent and Selective Inhibitor of Protein Kinase C Isotypes

(2009) Jürgen Wagner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selectivity and therapeutic inhibition of kinases: to be or not to be?

(2009) Kamran Ghoreschi et al.   NATURE IMMUNOLOGY