An overview of patented small molecule stearoyl coenzyme-A desaturase inhibitors (2009 – 2013)
出版年份 2013 全文链接
标题
An overview of patented small molecule stearoyl coenzyme-A desaturase inhibitors (2009 – 2013)
作者
关键词
-
出版物
EXPERT OPINION ON THERAPEUTIC PATENTS
Volume 24, Issue 2, Pages 155-175
出版商
Informa Healthcare
发表日期
2013-11-20
DOI
10.1517/13543776.2014.851669
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- A Novel Inhibitor of Stearoyl-CoA Desaturase-1 Attenuates Hepatic Lipid Accumulation, Liver Injury and Inflammation in Model of Nonalcoholic Steatohepatitis
- (2013) Nobuya Kurikawa et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Medicinal Chemistry Design Principles for Liver Targeting Through OATP Transporters
- (2013) Meihua Tu et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands
- (2013) Josef G. Meingassner et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Stearoyl-CoA desaturase: a novel therapeutic target for RCC
- (2013) Annette Fenner Nature Reviews Urology
- Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1)
- (2012) Yongqi Deng et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Recent Advances on Stearoyl-Coa Desaturase Regulation in Fatty Liver Diseases
- (2012) Michel Narce et al. CURRENT DRUG METABOLISM
- Discovery of Piperazin-1-ylpyridazine-Based Potent and Selective Stearoyl-CoA Desaturase-1 Inhibitors for the Treatment of Obesity and Metabolic Syndrome
- (2012) Zaihui Zhang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Estimated plasma stearoyl co-A desaturase-1 activity and risk of incident diabetes: The Atherosclerosis Risk in Communities (ARIC) study
- (2012) Lisa S. Chow et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- StearoylCoA Desaturase-5: A Novel Regulator of Neuronal Cell Proliferation and Differentiation
- (2012) Debora I. Sinner et al. PLoS One
- Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: From systemic to liver-targeting inhibitors
- (2011) Yeeman K. Ramtohul et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy
- (2011) David A. Powell et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- N-Benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors
- (2011) Karen A. Atkinson et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors
- (2011) Jean-Philippe Leclerc et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series
- (2011) Nicolas Lachance et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series
- (2011) Nicolas Lachance et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Bioinformatics and Systems Biology of the Lipidome
- (2011) Shankar Subramaniam et al. CHEMICAL REVIEWS
- Plasma-based approach to measure target engagement for liver-targeting stearoyl-CoA desaturase 1 inhibitors
- (2011) France Landry et al. JOURNAL OF LIPID RESEARCH
- Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia
- (2011) Renata M. Oballa et al. JOURNAL OF MEDICINAL CHEMISTRY
- Stearoyl CoA desaturase (SCD) facilitates proliferation of prostate cancer cells through enhancement of androgen receptor transactivation
- (2011) Seung-Jin Kim et al. MOLECULES AND CELLS
- Elevated Stearoyl-CoA Desaturase in Brains of Patients with Alzheimer's Disease
- (2011) Giuseppe Astarita et al. PLoS One
- SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors
- (2010) Yeeman K. Ramtohul et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- 2-Aryl benzimidazoles: Human SCD1-specific stearoyl coenzyme-A desaturase inhibitors
- (2010) David A. Powell et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors
- (2010) Elise Isabel et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Stearoyl-coenzyme A desaturase 1 inhibition and the metabolic syndrome: considerations for future drug discovery
- (2010) J Mark Brown et al. CURRENT OPINION IN LIPIDOLOGY
- Recent Advances in Stearoyl-CoA Desaturase 1 Inhibitors for Dyslipidemia and Obesity
- (2010) Gang Liu CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Hepatic OATP and OCT uptake transporters: their role for drug-drug interactions and pharmacogenetic aspects
- (2010) Christina Fahrmayr et al. DRUG METABOLISM REVIEWS
- Synthesis and evaluation of novel stearoyl-CoA desaturase 1 inhibitors: 1′-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4′-piperidine] analogs
- (2010) Yoshikazu Uto et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Novel substituted heteroaromatic compounds as inhibitors of stearoyl-CoA desaturase
- (2010) Pawel Dobrzyn et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Genetic variation in lipid desaturases and its impact on the development of human disease
- (2010) Diana M Merino et al. Lipids in Health and Disease
- Rapamycin Regulates Stearoyl CoA Desaturase 1 Expression in Breast Cancer
- (2010) D. Luyimbazi et al. MOLECULAR CANCER THERAPEUTICS
- Inhibition of StearoylCoA Desaturase Activity Blocks Cell Cycle Progression and Induces Programmed Cell Death in Lung Cancer Cells
- (2010) Daniel Hess et al. PLoS One
- Lipid oversupply, selective insulin resistance, and lipotoxicity: Molecular mechanisms
- (2009) Jose Antonio Chavez et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Thiazole analog as stearoyl-CoA desaturase 1 inhibitor
- (2009) Chun Sing Li et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors
- (2009) Dmitry O. Koltun et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide
- (2009) Yoshikazu Uto et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors
- (2009) Dmitry O. Koltun et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation
- (2009) Yoshikazu Uto et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors
- (2009) Dmitry O. Koltun et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats
- (2009) Yoshikazu Uto et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)
- (2009) Serge Léger et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1′-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4′-piperidine]
- (2009) Yoshikazu Uto et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Pharmacological inhibition of Stearoyl-CoA Desaturase 1 improves insulin sensitivity in insulin-resistant rat models
- (2009) Marc Issandou et al. EUROPEAN JOURNAL OF PHARMACOLOGY
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- (2009) Gang Liu EXPERT OPINION ON THERAPEUTIC PATENTS
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- (2009) Natalia Scaglia et al. PLoS One
- Association of Stearoyl-CoA Desaturase 1 Activity With Familial Combined Hyperlipidemia
- (2008) Rebecca Mar-Heyming et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors
- (2008) Zhili Xin et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Inhibition of Stearoyl-Coenzyme A Desaturase 1 Dissociates Insulin Resistance and Obesity From Atherosclerosis
- (2008) J. Mark Brown et al. CIRCULATION
- Comparison of pig, sheep and chicken SCD5 homologs: Evidence for an early gene duplication event
- (2008) Andrea J. Lengi et al. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
- Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans
- (2008) N. Stefan et al. DIABETOLOGIA
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