Article
Nanoscience & Nanotechnology
Dongying Li, Jiarun Li, Siwei Wang, Wei Teng, Qinmei Wang
Summary: Efficient introduction of iRGD onto nanopolymersomes was achieved using a physical method, allowing for precise control of the amount incorporated. The iRGD-decorated nanopolymersomes exhibited excellent tumor-targeting and penetration capabilities, facilitating effective delivery of siRNA to inhibit tumor growth.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Jang Hyuk Bang, Yeong Chae Ryu, Kyung Ah Kim, Byeong Hee Hwang
Summary: This study developed a self-assembled nanocomplex combining fusion peptides and small RNAs for efficient, stable, and targeted delivery to breast cancer cells. The results showed that the nanocomplexes exhibited prolonged stability, enhanced cellular uptake, and effectively inhibited breast cancer cell growth, with no significant cytotoxicity observed in in vitro and in vivo tests.
BIOCHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biotechnology & Applied Microbiology
Yeong Chae Ryu, Kyung Ah Kim, Byoung Choul Kim, Hui-Min David Wang, Byeong Hee Hwang
Summary: Novel synergy fusion peptides SPACE and oligoarginine improved cellular uptake and gene silencing effect of siRNA in vitro, as well as retention and gene silencing effects of siRNAs in vivo. The nanocomplexes using fusion peptides showed enhanced cellular uptake and gene silencing effects via lipid raft-mediated endocytosis pathway, making them a potential safe and efficient platform for delivering siRNAs for gene silencing therapies.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Soon Gil Jeong, Yeong Chae Ryu, Byeong Hee Hwang
Summary: The novel synergistic nanocomplexes designed in this study efficiently transfected cells, improved gene expression, and showed good biocompatibility. This new strategy provides an efficient and safe gene carrier for treating various genetic diseases.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Environmental
Tarek A. Seaf A. Elnasr, Omar M. Ibrahim, Mosaed S. Alhumaimess, Ibrahim Hotan Alsohaimi, Yasser A. El-Ossaily, Modather F. Hussein, Atef Mohamed Nassar, Hassan M. A. Hassan, M. R. El-Aassar, Elsayed E. Hafez
Summary: Our study developed a new nanocomposite agent called CS/SeNPs@Jouf Oo to address the harmful effects of anticancer chemotherapies on healthy tissues. The nanocomposite demonstrated effective anticancer activity on human colorectal adenocarcinoma, human hepatocellular carcinoma, and human breast cancer cell lines, with a safer profile on normal cells compared to traditional chemotherapy. Mechanistic analyses revealed alterations in apoptotic oncogenes, suggesting that the nanocomposite provides a safer and more targeted alternative for cancer treatment.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Chemistry, Multidisciplinary
Alexander V. Mikheev, Tatiana N. Pallaeva, Ivan A. . Burmistrov, Vladimir V. Artemov, Dmitry N. Khmeleni, Fedor S. Fedorov, Albert G. Nasibulin, Daria B. Trushina
Summary: A hybrid core-shell system was fabricated using two technical approaches and freezing-induced loading was found to be more preferable compared to physical adsorption.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Nanoscience & Nanotechnology
Dayoung Lee, Seungki Baek, Young-Youb Kim, Yongbin Bang, Han Na Jung, Hyung-Jun Im, Yoon-Kyu Song
Summary: In this study, hybrid nanospheres composed of DNA and proteins were developed for cancer targeting. The nanospheres showed excellent biocompatibility, high drug payload capacity, and in vivo imaging ability. The feasibility of cancer targeting and drug-loading capacity were tested, and the nanospheres were proven to have selective internalization in cancer cells.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Liyun Cui, Sainan Liu, Fan Wu, Hua Chen, Yuanfeng Li, Linqi Shi, Yong Liu, Rujiang Ma
Summary: This study reports a protein@PP-Zn nanocomplex for efficient intracellular protein delivery, where the protein is conjugated with a block polymer PEG-b-PAE(Im) via the bridging effect of zinc ions. The nanocomplex promotes endocytosis in a slightly acidic environment near cancer cells, and leads to the breakdown of endosomes in a more acidic environment, resulting in protein release into the cytoplasm. This work provides a stable, efficient, and universal strategy for intracellular protein delivery.
SCIENCE CHINA-CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Xin Wu, Xiaobo Zhang, Wanjiang Feng, Haoming Feng, Zhiyu Ding, Qiangqiang Zhao, Xisheng Li, Ning Tang, Pan Zhang, Jian Li, Jianlong Wang
Summary: A multifunctional nanodrug system (V-RZCD) targeting osteosarcoma has been developed in this study, which can inhibit the proliferation of osteosarcoma and significantly suppress osteolysis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biophysics
Qiang Li, Dongsheng Fu, Jie Zhang, Hong Yan, Huifang Wang, Baolong Niu, Ruijie Guo, Yiming Liu
Summary: A new type of polypeptide-based dual-sensitive drug delivery system was synthesized for efficient chemotherapy. The nanoparticles showed enhanced drug release in acidic and hypoxic environments, leading to higher cytotoxicity against lung cancer cells. This system has the potential to be a promising platform for stimuli-responsive controlled drug release in cancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Jie Zhu, Rui Gao, Zhongshi Wang, Zhiming Cheng, Zhonghua Xu, Zaiyang Liu, Yiqun Wu, Min Wang, Yuan Zhang
Summary: A pH-responsive nonapeptide hydrogel was designed and fabricated for tumor-targeted drug delivery, which exhibited good injectability and biocompatibility. The drug-loaded hydrogel showed high sensitivity to acidic conditions and could amplify the therapeutic effect and increase drug accumulation at the tumor site in vivo.
Review
Chemistry, Multidisciplinary
Masoud Delfi, Rossella Sartorius, Milad Ashrafizadeh, Esmaeel Sharifi, Yapei Zhang, Piergiuseppe De Berardinis, Ali Zarrabi, Rajender S. Varma, Franklin R. Tay, Bryan Ronain Smith, Pooyan Makvandi
Summary: Self-assembled peptides and proteins have great potential as targeted drug delivery systems, especially in anti-cancer therapy. They can form diverse nanostructures in response to environmental conditions and offer good biocompatibility and high loading capacity for drugs, making them ideal for specific targeting of tumor cells.
Article
Pharmacology & Pharmacy
Fan Jia, Yunhao Li, Yujuan Gao, Xuan Wang, Jianqing Lu, Xinyue Cui, Zian Pan, Chenlu Xu, Xiongwei Deng, Yan Wu
Summary: In this study, a combination of anti-angiogenic therapy and gene therapy was used for synergistic anti-tumor treatment. The results showed that FCNP exhibited significant synergistic antitumor efficacy via anti-angiogenesis and gene therapy in the colorectal cancer model, with favorable biosafety and biocompatibility.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Biomedical
Yue Gao, Zhijun Ouyang, Chao Yang, Cong Song, Chunjuan Jiang, Shaoli Song, Minguiu Shen, Xiangyang Shi
Summary: A novel dendrimer-based nanohybrid platform is developed for dual-mode CT/MR imaging-guided cancer immunotherapy by regulating T cell exhaustion, showing promising potential for overcoming immune escape of cancer cells and improving the efficiency of cancer immunotherapy.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Laura Sanchez-Garcia, Eric Volta-Duran, Eloi Parlade, Elisa Mazzega, Alejandro Sanchez-Chardi, Naroa Serna, Hector Lopez-Laguna, Mara Mitstorfer, Ugutz Unzueta, Esther Vazquez, Antonio Villaverde, Ario de Marco
Summary: Nanobodies are valuable tools in advanced therapeutic strategies, but their small size and limited valence for interactions may pose restrictions for in vivo applications. Modular protein constructs have been designed to fuse nanobodies with protein domains, promoting self-assembly into stable nanoparticles with maintained specificity for targets.
ACS APPLIED MATERIALS & INTERFACES
(2021)
