标题
A patent review of sirtuin activators: an update
作者
关键词
-
出版物
EXPERT OPINION ON THERAPEUTIC PATENTS
Volume 22, Issue 4, Pages 355-367
出版商
Informa Healthcare
发表日期
2012-03-09
DOI
10.1517/13543776.2012.669374
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Comparative transcriptional profiling identifies takeout as a gene that regulates life span
- (2016) Johannes Bauer et al. Aging-US
- Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
- (2012) Sung-Jun Park et al. CELL
- Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells
- (2011) Dharminder Chauhan et al. BRITISH JOURNAL OF HAEMATOLOGY
- Phase I Randomized, Double-Blind Pilot Study of Micronized Resveratrol (SRT501) in Patients with Hepatic Metastases--Safety, Pharmacokinetics, and Pharmacodynamics
- (2011) L. M. Howells et al. Cancer Prevention Research
- Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
- (2011) Silvie Timmers et al. Cell Metabolism
- Advances in Characterization of Human Sirtuin Isoforms: Chemistries, Targets and Therapeutic Applications
- (2011) Y. Cen et al. CURRENT MEDICINAL CHEMISTRY
- Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats
- (2011) Colette M. Knight et al. DIABETES
- Systemic SIRT1 insufficiency results in disruption of energy homeostasis and steroid hormone metabolism upon high-fat-diet feeding
- (2011) Aparna Purushotham et al. FASEB JOURNAL
- Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by Sirt1 Protein-mediated Deacetylation
- (2011) William C. Hallows et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
- (2011) Rui-Hong Wang et al. JOURNAL OF CLINICAL INVESTIGATION
- Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
- (2011) Camilla Burnett et al. NATURE
- Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
- (2011) Mali Jiang et al. NATURE MEDICINE
- Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
- (2011) Hyunkyung Jeong et al. NATURE MEDICINE
- Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment
- (2011) Keisuke Fujitaka et al. NUTRITION RESEARCH
- Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity
- (2011) Stephen J. Clark et al. Obesity
- What Is New for an Old Molecule? Systematic Review and Recommendations on the Use of Resveratrol
- (2011) Ole Vang et al. PLoS One
- Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase
- (2011) J. Du et al. SCIENCE
- SRT1720 improves survival and healthspan of obese mice
- (2011) Robin K. Minor et al. Scientific Reports
- Mammalian Sirtuins: Biological Insights and Disease Relevance
- (2010) Marcia C. Haigis et al. Annual Review of Pathology-Mechanisms of Disease
- Sirtuin chemical mechanisms
- (2010) Anthony A. Sauve BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Effects of Longevinex (modified resveratrol) on cardioprotection and its mechanisms of action
- (2010) Subhendu Mukherjee et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction
- (2010) Shinichi Someya et al. CELL
- SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity
- (2010) Giorgio Ramadori et al. Cell Metabolism
- Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle
- (2010) Carles Cantó et al. Cell Metabolism
- SIRT1 mRNA Expression May Be Associated With Energy Expenditure and Insulin Sensitivity
- (2010) J. Rutanen et al. DIABETES
- Role of Sirtuin 1 in metabolic regulation
- (2010) Jose P. Silva et al. DRUG DISCOVERY TODAY
- Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via Agouti-Related Peptide
- (2010) Tsutomu Sasaki et al. ENDOCRINOLOGY
- SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183
- (2010) Julie L Huber et al. Future Medicinal Chemistry
- SIRT1 Activation by Small Molecules
- (2010) Han Dai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1
- (2010) Michelle Pacholec et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SRT1720 Induces Mitochondrial Biogenesis and Rescues Mitochondrial Function after Oxidant Injury in Renal Proximal Tubule Cells
- (2010) J. A. Funk et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Resveratrol, sirtuins, and the promise of a DR mimetic
- (2010) Joseph A. Baur MECHANISMS OF AGEING AND DEVELOPMENT
- Reduction of blood cholesterol and ischemic injury in the hypercholesteromic rabbits with modified resveratrol, logevinex
- (2010) Bela Juhaz et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1
- (2010) Masato Iwabu et al. NATURE
- Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure
- (2010) R.H.X. Wong et al. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
- Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124
- (2010) D. S. Auld et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases
- (2010) Shin-ichiro Imai et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice
- (2009) Yu Yamazaki et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- A fluorometric assay of SIRT1 deacetylation activity through quantification of nicotinamide adenine dinucleotide
- (2009) Yu Feng et al. ANALYTICAL BIOCHEMISTRY
- A continuous microplate assay for sirtuins and nicotinamide-producing enzymes
- (2009) Brian C. Smith et al. ANALYTICAL BIOCHEMISTRY
- Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
- (2009) Jesse J Smith et al. BMC Systems Biology
- Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity
- (2009) Dirk Beher et al. Chemical Biology & Drug Design
- AMP-Activated Protein Kinase-Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol
- (2009) J.-H. Um et al. DIABETES
- Sirtuin activators
- (2009) Francisco J Alcaín et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators
- (2009) Chi B. Vu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Study of 1,4-Dihydropyridine Structural Scaffold: Discovery of Novel Sirtuin Activators and Inhibitors
- (2009) Antonello Mai et al. JOURNAL OF MEDICINAL CHEMISTRY
- Human Sirt-1: Molecular Modeling and Structure-Function Relationships of an Unordered Protein
- (2009) Ida Autiero et al. PLoS One
- Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations
- (2008) Anna Csiszar et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators
- (2008) Jean E. Bemis et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span
- (2008) Kevin J. Pearson et al. Cell Metabolism
- Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation
- (2008) Jérôme N. Feige et al. Cell Metabolism
- Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart
- (2008) J.L. Barger et al. EXPERIMENTAL GERONTOLOGY
- Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability
- (2008) G. Ramadori et al. JOURNAL OF NEUROSCIENCE
- The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men
- (2008) Xiang-Jiao Yang et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice
- (2008) Gino Boily et al. PLoS One
- A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice
- (2008) Jamie L. Barger et al. PLoS One
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now