c-FMS inhibitors: a patent review

Discovery of a new potent bisamide FMS kinase inhibitor

(2010) Mohammed I. El-Gamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode

(2010) Marvin J. Meyers et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Interleukin-6, IL-6 receptor, and IL-6 nuclear factor gene expression in paget's disease

(2010) Judith A. Hoyland et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The (un)targeted cancer kinome

(2010) Oleg Fedorov et al.   Nature Chemical Biology

Colony-Stimulating Factor-1 Receptor Inhibitors for the Treatment of Cancer and Inflammatory Disease

(2009) Sharmila Patel et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis

(2009) Yoshiaki Kubota et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pyrido[2,3-d]pyrimidin-5-ones: A Novel Class of Antiinflammatory Macrophage Colony-Stimulating Factor-1 Receptor Inhibitors†

(2009) Hui Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia

(2009) C. L. Manthey et al.   MOLECULAR CANCER THERAPEUTICS

Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor α, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor

(2008) Inmaculada Rioja et al.   ARTHRITIS AND RHEUMATISM

Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors

(2008) Mark J. Wall et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-based optimization of a potent class of arylamide FMS inhibitors

(2008) Sanath K. Meegalla et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of novel FMS kinase inhibitors as anti-inflammatory agents

(2008) Carl R. Illig et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer

(2008) David A. Scott et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS

(2008) Christopher J. Burns et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

3-Amido-4-anilinoquinolines as CSF-1R kinase inhibitors 2: Optimization of the PK profile

(2008) David A. Scott et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase

(2008) David A. Scott et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Macrophage colony stimulating factor: Not just for macrophages anymore! A gateway into complex biologies

(2008) Thomas G. Douglass et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The selective M-CSF receptor tyrosine kinase inhibitor Ki20227 suppresses experimental autoimmune encephalomyelitis

(2008) Yasunori Uemura et al.   JOURNAL OF NEUROIMMUNOLOGY

Effects of the cFMS Kinase Inhibitor 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in Normal and Arthritic Rats

(2008) J. G. Conway et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

(2008) H. Lin et al.   SCIENCE

The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model

(2007) Hiroaki Ohno et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

1,25-Dihydroxyvitamin D3 Hypersensitivity of Osteoclast Precursors from Patients with Paget's Disease

(2006) Cheikh Menaa et al.   JOURNAL OF BONE AND MINERAL RESEARCH