Cyclotides: a patent review

Biological Activities of Natural and Engineered Cyclotides, a Novel Molecular Scaffold for Peptide-Based Therapeutics

(2012) Angie E. Garcia et al.   Current Molecular Pharmacology

Discovery of Cyclotides in the Fabaceae Plant Family Provides New Insights into the Cyclization, Evolution, and Distribution of Circular Proteins

(2011) Aaron G. Poth et al.   ACS Chemical Biology

Bioactive cystine knot proteins

(2011) Norelle L Daly et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Discovery and Characterization of Novel Cyclotides Originated from Chimeric Precursors Consisting of Albumin-1 Chain a and Cyclotide Domains in the Fabaceae Family

(2011) Giang Kien Truc Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chemistry of Cyclotides

(2011) David J Craik et al.   JOURNAL OF ORGANIC CHEMISTRY

Albumins and their processing machinery are hijacked for cyclic peptides in sunflower

(2011) Joshua S Mylne et al.   Nature Chemical Biology

Discovery of an unusual biosynthetic origin for circular proteins in legumes

(2011) A. G. Poth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclotides, a promising molecular scaffold for peptide-based therapeutics

(2010) Krishnappa Jagadish et al.   BIOPOLYMERS

Cyclotide synthesis and supply: From plant to bioprocess

(2010) Heike Dörnenburg   BIOPOLYMERS

Evaluation of toxicity and antitumor activity of cycloviolacin O2 in mice

(2010) Robert Burman et al.   BIOPOLYMERS

Anticancer and chemosensitizing abilities of cycloviolacin O2 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa

(2010) Samantha L. Gerlach et al.   BIOPOLYMERS

Isolation, Sequencing, and Structure−Activity Relationships of Cyclotides

(2010) David C. Ireland et al.   JOURNAL OF NATURAL PRODUCTS

“Splicing up” drug discovery.☆Cell-based expression and screening of genetically-encoded libraries of backbone-cyclized polypeptides

(2009) Harshkumar Sancheti et al.   ADVANCED DRUG DELIVERY REVIEWS

In vivo biosynthesis of an Ala-scan library based on the cyclic peptide SFTI-1

(2009) Jeffrey Austin et al.   AMINO ACIDS

Progress in kalata peptide production via plant cell bioprocessing

(2009) Heike Dörnenburg   Biotechnology Journal

Cyclotides: macrocyclic peptides with applications in drug design and agriculture

(2009) David J. Craik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Biosynthesis and Biological Screening of a Genetically Encoded Library Based on the Cyclotide MCoTI-I

(2009) Jeffrey Austin et al.   CHEMBIOCHEM

Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins

(2009) Harald Kolmar   CURRENT OPINION IN PHARMACOLOGY

Cyclotides as templates in drug design

(2009) Sónia Troeira Henriques et al.   DRUG DISCOVERY TODAY

Circular proteins from Melicytus (Violaceae) refine the conserved protein and gene architecture of cyclotides

(2009) Manuela Trabi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Circling the enemy: cyclic proteins in plant defence

(2009) David J. Craik   TRENDS IN PLANT SCIENCE

Anthelmintic activity of cyclotides: In vitro studies with canine and human hookworms

(2008) Michelle L. Colgrave et al.   ACTA TROPICA

Thrombopoietin and Thrombopoietin Mimetics in the Treatment of Thrombocytopenia

(2008) David J. Kuter   Annual Review of Medicine

Cyclotides: Natural, Circular Plant Peptides that Possess Significant Activity against Gastrointestinal Nematode Parasites of Sheep†

(2008) Michelle L. Colgrave et al.   BIOCHEMISTRY

Plant cell culture technology–harnessing a biological approach for competitive cyclotides production

(2008) Heike Dörnenburg   BIOTECHNOLOGY LETTERS

The Anthelmintic Activity of the Cyclotides: Natural Variants with Enhanced Activity

(2008) Michelle L. Colgrave et al.   CHEMBIOCHEM

Identification of two suites of cyclotide precursor genes from metallophyte Viola baoshanensis: cDNA sequence variation, alternative RNA splicing and potential cyclotide diversity

(2008) Jun Zhang et al.   GENE

Backbone Cyclised Peptides from Plants Show Molluscicidal Activity against the Rice PestPomacea canaliculata(Golden Apple Snail)

(2008) Manuel Rey R. Plan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Alanine Scanning Mutagenesis of the Prototypic Cyclotide Reveals a Cluster of Residues Essential for Bioactivity

(2008) Shane M. Simonsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plant cell-based processes for cyclotides production

(2008) Heike Dörnenburg et al.   JOURNAL OF BIOTECHNOLOGY

Engineering Stabilized Vascular Endothelial Growth Factor-A Antagonists: Synthesis, Structural Characterization, and Bioactivity of Grafted Analogues of Cyclotides

(2008) Sunithi Gunasekera et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides

(2008) Panumart Thongyoo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity

(2008) Anders Herrmann et al.   PHYTOCHEMISTRY

Distribution and Evolution of Circular Miniproteins in Flowering Plants

(2008) C. W. Gruber et al.   PLANT CELL

Plant cyclotides disrupt epithelial cells in the midgut of lepidopteran larvae

(2008) B. L. Barbeta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Knottin cyclization: impact on structure and dynamics

(2008) Annie Heitz et al.   BMC STRUCTURAL BIOLOGY