Recent advances in histamine H3receptor antagonists/inverse agonists

Acidic elements in histamine H3 receptor antagonists

(2010) Kerstin Sander et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists

(2010) Emily M. Stocking et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In vitro studies on a class of quinoline containing histamine H3 antagonists

(2010) Huaqing Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Exploration of Structure-Activity Relationships for Dual Serotonin Transporter Reuptake Inhibitors-Histamine H3 Receptor Antagonists

(2010) Emily M. Stocking et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Histamine H3 Antagonists for Treatment of Cognitive Deficits in CNS Diseases

(2010) Rita Raddatz et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Selective naphthalene H3 receptor inverse agonists with reduced potential to induce phospholipidosis and their quinoline analogs

(2009) Rosa María Rodríguez Sarmiento et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A novel class of H3 antagonists derived from the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin

(2009) J. Phillip Kennedy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Benzimidazole- and indole-substituted 1,3′-bipyrrolidine benzamides as histamine H3 receptor antagonists

(2009) Derek C. Cole et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The histamine H3 receptor as a therapeutic drug target for CNS disorders

(2009) Mark J. Gemkow et al.   DRUG DISCOVERY TODAY

Modulation of the Partition Coefficient between Octanol and Buffer at pH 7.4 and pKa to Achieve the Optimum Balance of Blood Clearance and Volume of Distribution for a Series of Tetrahydropyran Histamine Type 3 Receptor Antagonists

(2009) T. Hay et al.   DRUG METABOLISM AND DISPOSITION

Histamine H3and H4receptors as novel drug targets

(2009) Ekaterini Tiligada et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Design and Evaluation of Novel Biphenyl Sulfonamide Derivatives with Potent Histamine H3Receptor Inverse Agonist Activity

(2009) Jonathan A. Covel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design of a New Histamine H3Receptor Antagonist Chemotype: (3aR,6aR)-5-Alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, Synthesis, and Structure−Activity Relationships

(2009) Chen Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

5-Hydroxyindole-2-carboxylic Acid Amides: Novel Histamine-3 Receptor Inverse Agonists for the Treatment of Obesity

(2009) Pascale David Pierson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Measurement of the pharmacokinetics and pharmacodynamics of neuroactive compounds

(2009) Mohammad S. Alavijeh et al.   NEUROBIOLOGY OF DISEASE

A Robust and High-Capacity [35S]GTPγS Binding Assay for Determining Antagonist and Inverse Agonist Pharmacological Parameters of Histamine H3 Receptor Ligands

(2008) Thomas R. Miller et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Histamine H3 Receptor Antagonists Go to Clinics

(2008) Kerstin Sander et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Development of novel 2-[4-(aminoalkoxy)phenyl]-4(3H)-quinazolinone derivatives as potent and selective histamine H3 receptor inverse agonists

(2008) Takashi Mizutani et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The histamine H3receptor: an attractive target for the treatment of cognitive disorders

(2008) T A Esbenshade et al.   BRITISH JOURNAL OF PHARMACOLOGY

Histamine H3 Antagonists as Wake-Promoting and Pro-Cognitive Agents

(2008) Emily Stocking et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Minimization of potential hERG liability in histamine H3 receptor antagonists

(2008) L. A. Black et al.   INFLAMMATION RESEARCH

Synthesis, Structure−Activity Relationships, and Biological Profiles of a Quinazolinone Class of Histamine H3Receptor Inverse Agonists

(2008) Tsuyoshi Nagase et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Evaluation of Structurally Constrained Quinazolinone Derivatives as Potent and Selective Histamine H3Receptor Inverse Agonists

(2008) Tsuyoshi Nagase et al.   JOURNAL OF MEDICINAL CHEMISTRY

Total Synthesis and Biological Evaluation of the Marine Bromopyrrole Alkaloid Dispyrin: Elucidation of Discrete Molecular Targets with Therapeutic Potential

(2008) J. Phillip Kennedy et al.   JOURNAL OF NATURAL PRODUCTS

Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain

(2008) Stephen J. Medhurst et al.   PAIN

Lead identification of acetylcholinesterase inhibitors–histamine H3 receptor antagonists from molecular modeling

(2007) Scott D. Bembenek et al.   BIOORGANIC & MEDICINAL CHEMISTRY