Small molecules for bone diseases

A double-blinded head-to-head trial of minodronate and alendronate in women with postmenopausal osteoporosis

(2009) Hiroshi Hagino et al.   BONE

Effect of the Cathepsin K Inhibitor Odanacatib on Bone Resorption Biomarkers in Healthy Postmenopausal Women: Two Double-Blind, Randomized, Placebo-Controlled Phase I Studies

(2009) S A Stoch et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Anti-Tumour Effects of Bisphosphonates - What have we Learned from In Vivo Models?

(2009) H. Brown et al.   CURRENT CANCER DRUG TARGETS

Prostaglandin EP2 and EP4 receptor agonists in bone formation and bone healing:In vivoandin vitroevidence

(2009) Simon Graham et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Wnt signaling as a therapeutic target for bone diseases

(2009) Luke H Hoeppner et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Discovery of Potent, Selective, and Orally Active Carboxylic Acid Based Inhibitors of Matrix Metalloproteinase-13†

(2009) Lauren G. Monovich et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Enoxacin as an Inhibitor of Osteoclast Formation and Bone Resorption by Structure-Based Virtual Screening

(2009) David A. Ostrov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thermodynamics of Bisphosphonates Binding to Human Bone: A Two-Site Model

(2009) Sujoy Mukherjee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Large-scale synthesis of SB-462795, a cathepsin K inhibitor: the RCM-based approaches

(2009) Huan Wang et al.   TETRAHEDRON

Use of Alendronate and Risk of Incident Atrial Fibrillation in Women

(2008) Susan R. Heckbert et al.   ARCHIVES OF INTERNAL MEDICINE

Synthesis and biological evaluation of indolyl bisphosphonates as anti-bone resorptive and anti-leishmanial agents

(2008) Uma Sharan Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

N-((8-Hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2)

(2008) Adam M. Gilbert et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effect of novel N-cyano-tetrahydro-pyridazine compounds, a class of cathepsin K inhibitors, on the bone resorptive activity of mature osteoclasts

(2008) Seong Hwan Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

(2008) Jacques Yves Gauthier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and initial evaluation of novel, non-peptidic antagonists of the αv-integrins αvβ3 and αvβ5

(2008) Jeffrey J. Letourneau et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Joint Diseases and Matrix Metalloproteinases: A Role for MMP-13

(2008) Hironari Takaishi et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Drug discovery in the extracellular matrix

(2008) Julie Huxley-Jones et al.   DRUG DISCOVERY TODAY

Potential directions for drug development for osteoarthritis

(2008) Helmtrud I Roach   Expert Opinion on Drug Discovery

Novel bone cancer drugs: investigational agents and control paradigms for primary bone sarcomas (Ewing's sarcoma and osteosarcoma)

(2008) Pete Anderson et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Bone disease drug discovery: examining the interactions between osteoblast and osteoclast

(2008) Sengen Sun   EXPERT OPINION ON THERAPEUTIC TARGETS

Effect of Cathepsin K Inhibitors on Bone Resorption

(2008) Naoki Teno et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Diarylsulfone Sulfonamides as Secreted Frizzled Related Protein-1 (sFRP-1) Inhibitors

(2008) Ariamala Gopalsamy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of a Nonbasic, Nitrile-Containing Cathepsin K Inhibitor (MK-1256) that is Efficacious in a Monkey Model of Osteoporosis

(2008) Jöel Robichaud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Subnanomolar Arginine-Glycine-Aspartate-Based αVβ3/αVβ5Integrin Binders Embedding 4-Aminoproline Residues

(2008) Franca Zanardi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modulation of Wnt Signaling Through Inhibition of Secreted Frizzled-Related Protein I (sFRP-1) with N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides†

(2008) William J. Moore et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effect of daily oral minodronate on vertebral fractures in Japanese postmenopausal women with established osteoporosis: a randomized placebo-controlled double-blind study

(2008) T. Matsumoto et al.   OSTEOPOROSIS INTERNATIONAL

Novel Anti-Cancer Strategy in Bone Tumors by Targeting Molecular and Cellular Modulators of Bone Resorption

(2008) Brounais Benedicte et al.   Recent Patents on Anti-Cancer Drug Discovery

Synthesis and evaluation of a γ-lactam as a highly selective EP2 and EP4 receptor agonist

(2007) Yufang Xiao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of novel potent and selective integrin αvβ3 antagonists—Novel synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates

(2007) Werner Seitz et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS