Liver X receptor modulators: a review of recently patented compounds (2007 – 2009)

Greasing the wheels of Aβ clearance in Alzheimer's Disease: The role of lipids and apolipoprotein E

(2009) Jianjia Fan et al.   BIOFACTORS

4-(3-Aryloxyaryl)quinoline alcohols are liver X receptor agonists

(2009) Ronald C. Bernotas et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRβ

(2009) Baihua Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists

(2009) Jeremy M. Travins et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRβ and low blood–brain penetration

(2009) Baihua Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists

(2009) Robert R. Singhaus et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists

(2009) Ronald C. Bernotas et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

(2009) Noelia A-Gonzalez et al.   IMMUNITY

Safety, Pharmacokinetics, and Pharmacodynamics of Single Doses of LXR-623, a Novel Liver X-Receptor Agonist, in Healthy Participants

(2009) Arie Katz et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity

(2009) Jihong Xu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

ApoE 4 reduces the expression of Aβ degrading enzyme IDE by activating the NMDA receptor in hippocampal neurons

(2009) Jing Du et al.   NEUROSCIENCE LETTERS

Biarylether amide quinolines as liver X receptor agonists

(2008) Ronald C. Bernotas et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Effect of T0901317 on ATP-binding Cassette Transporter A1 and Niemann-Pick Type C1 in ApoE???/??? Mice

(2008) Xiao-yan Dai et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia

(2008) Adelheid Kratzer et al.   JOURNAL OF LIPID RESEARCH

Indazole-Based Liver X Receptor (LXR) Modulators with Maintained Atherosclerotic Lesion Reduction Activity but Diminished Stimulation of Hepatic Triglyceride Synthesis∥

(2008) Jay Wrobel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels

(2008) D. R. Riddell et al.   JOURNAL OF NEUROSCIENCE

Antiatherosclerotic Effects of a Novel Synthetic Tissue-Selective Steroidal Liver X Receptor Agonist in Low-Density Lipoprotein Receptor-Deficient Mice

(2008) D. Peng et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON

Liver X receptor   (LXR ): A link between  -sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia

(2008) H.-J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liver X receptor agonist T0901317 reduces atherosclerotic lesions in apoE-/- mice by up-regulating NPC1 expression

(2008) Xiang Ou et al.   Science in China. Series C, Life sciences / Chinese Academy of Sciences

Carboxylic acid based quinolines as liver X receptor modulators that have LXRβ receptor binding selectivity

(2007) Baihua Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS