Therapeutic prospect of Syk inhibitors

Conformational rearrangements upon Syk auto-phosphorylation

(2009) Ernesto Arias-Palomo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival

(2009) Anurag Singh et al.   CANCER CELL

Spleen Tyrosine Kinase Functions as a Tumor Suppressor in Melanoma Cells by Inducing Senescence-like Growth Arrest

(2009) O. Bailet et al.   CANCER RESEARCH

Structural Insights for Design of Potent Spleen Tyrosine Kinase Inhibitors from Crystallographic Analysis of Three Inhibitor Complexes

(2009) Armando G. Villaseñor et al.   Chemical Biology & Drug Design

Treatment of rheumatoid arthritis with a syk kinase inhibitor: A twelve-week, randomized, placebo-controlled trial

(2008) Michael E. Weinblatt et al.   ARTHRITIS AND RHEUMATISM

A novel Syk family kinase inhibitor: Design, synthesis, and structure–activity relationship of 1,2,4-triazolo[4,3-c]pyrimidine and 1,2,4-triazolo[1,5-c]pyrimidine derivatives

(2008) Akihito Hirabayashi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)

(2008) Luc J. Farmer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk

(2008) A. Podolanczuk et al.   BLOOD

Spleen tyrosine kinase: a novel target for therapeutic intervention of rheumatoid arthritis

(2008) Malini Bajpai et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Molecular Mechanism of the Syk Activation Switch

(2008) Emily Tsang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells

(2008) S Gobessi et al.   LEUKEMIA

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

(2007) P. G. Longo et al.   BLOOD