期刊
EXPERT OPINION ON PHARMACOTHERAPY
卷 10, 期 17, 页码 2897-2904出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14656560903426189
关键词
glia; ibudilast; multiple sclerosis; neuropathic pain; priming
Ibudilast is a relatively nonselective phosphodiesterase inhibitor which has been marketed for a I most 20 years in Japan for treating asthma. More recently it has been found to have anti-inflammatory activity in both the peripheral immune system and in the CNS via glial cell attenuation. This CNS-directed anti-inflammatory activity is of potential use in the treatment of multiple sclerosis, neuropathic pain, and in the improved efficacy and safety of opioids by decreasing opioid tolerance, withdrawal and reinforcement. Its suitable pharmacokinetics and generally good tolerability make it a promising potential treatment for these conditions.
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