Review
Biology
Petros Ioannou, Stella Baliou, Diamantis P. Kofteridis
Summary: The article summarizes recent advancements in medical research and clinical practice, highlighting the significant limitations of antimicrobial resistance (AMR) on therapeutics for infectious diseases. It emphasizes the urgent need for novel treatments, particularly in the era of increasing AMR. Ongoing research is exploring non-classical therapies, such as bacteriophages or antimicrobial peptides (AMPs), that utilize alternative antimicrobial mechanisms to combat pathogens.
Review
Immunology
Sarah B. Green, Kayla R. Stover, Katie Barber, Jeannette L. Bouchard, Matthew L. Brown, Connor R. Deri, Bailey J. Francis, Timothy P. Gauthier, Jillian E. Hayes, Ashley H. Marx, Edoabasi U. McGee, Krutika Mediwala, Rachel J. Musgrove, Douglas Slain, Stefanie A. Stramel, Christopher M. Bland, P. Brandon Bookstaver
Summary: The number of articles related to antimicrobial stewardship has significantly increased over the past decade, with emphasis on innovative designs and practical applicability. The SERGE-45 network reviewed literature from 2020 and identified 13 significant publications, highlighting their importance as resources for teaching, training, and stewardship opportunities.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Review
Immunology
Vincenzo Costanzo, Giovanni N. Roviello
Summary: The misuse of antibiotics has led to an increase in antimicrobial resistance, which is now considered a global emergency. Therefore, new strategies to fight antimicrobial resistance are urgently needed. Vaccines are seen as a crucial approach in preventing the spread of pathogens and reducing the usage of antibiotics, but vaccines against resistant pathogens are still under clinical evaluation.
Review
Pharmacology & Pharmacy
Sandra Truong, Poonam Mudgil
Summary: This systematic review examines the antibacterial properties of lavender essential oil (LEO) against Staphylococcus aureus and MRSA. The findings suggest mixed results, with some studies reporting significant effectiveness and others reporting minimal to negligible effect. However, it is noted that LEO works synergistically with other antibacterial substances, highlighting the need for further research.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Yong Chan Kim, Ji Young Park, Bongyoung Kim, Eu Suk Kim, Hyuk Ga, Rangmi Myung, Se Yoon Park, Myung Jin Lee, Song Mi Moon, Sun Hee Park, Kyoung-Ho Song, Hong Bin Kim
Summary: The study aimed to evaluate the pattern and appropriateness of antibiotic usage in small hospitals in South Korea. The results showed variations in antibiotic prescription patterns among different types of hospitals, with a significant proportion of inappropriate prescriptions.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Review
Pharmacology & Pharmacy
Leon G. Leanse, Carolina dos Anjos, Sana Mushtaq, Tianhong Dai
Summary: This review provides an update on the recent studies exploring the antimicrobial effects of antimicrobial blue light (aBL) in the treatment of multidrug-resistant infections. The review focuses on the efficacy of aBL against different microbes, identification of endogenous chromophores and targets of aBL, resistance development to aBL, safety of aBL against host cells, and synergism of aBL with other agents. The review also offers insights into the future of aBL.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Sheng He, Leon G. Leanse, Yanfang Feng
Summary: In the era of antimicrobial resistance, infectious diseases have become significant global burdens that urgently require innovative treatment strategies. Emerging studies have shown that artificial intelligence can transform drug delivery to promote effective treatment of infectious diseases.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Immunology
Sigifredo Pedraza-Sanchez, Adrian Cruz-Gonzalez, Oscar Palmeros-Rojas, Jose Luis Galvez-Romero, Joseph A. Bellanti, Martha Torres
Summary: Antimicrobial resistance (AMR) is a global health problem causing over 1.27 million deaths annually, highlighting the need for urgent efforts to address this issue. Misuse of antibiotics and antimicrobials in agriculture, veterinary medicine, and human medicine is the primary cause of AMR, leading to the selection of drug-resistant microbes. One potential strategy to combat AMR is the use of polyvalent human immunoglobulin or IVIG, which enhances natural immunity to safely and physiologically eliminate bacteria, viruses, or fungi.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Infectious Diseases
Myung Jin Lee, Song Mi Moon, Bongyoung Kim, Se Yoon Park, Ji Young Park, Hyunsook Koo, Hyungmin Lee, Kyoung-Ho Song, Hyunju Lee, Jeong Su Park, Mi Suk Lee, Su-Mi Choi, Chung-Jong Kim, Hyun-Ha Chang, Tae Hyong Kim, Sun Hee Park, Eu Suk Kim, Hong Bin Kim
Summary: The study aimed to identify the status of antimicrobial stewardship programmes (ASPs) in small to medium-sized Korean hospitals and the awareness and demands about ASPs of physicians. Results showed that ID specialists were the majority of medical personnel participating in ASPs in tertiary care hospitals, while there was no predominant medical personnel for ASPs in secondary and primary care hospitals. Support for ASP improvement, including 'Workforce for ASPs', 'Establishment of healthcare fees for ASPs' and 'Development of tools for ASPs', is crucial.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Article
Infectious Diseases
Aisha S. Al Hamdan, Amal A. Alghamdi, Ghada F. Alyousif, Fatma A. Hamza, Marwa M. Shafey, Aisha M. AlAmri, Abdulaziz A. Sunki
Summary: The prevalence of multidrug-resistant organisms (MDROs) among Gram-negative bacteria (GNB) in the Security Forces Hospital Dammam (SFHD) was investigated in this study. The results showed a high rate of multidrug resistance among GNB, with variations observed among different patient demographics and types of clinical samples. The study highlights the need for antimicrobial stewardship programs and increased awareness of antibiotic use.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Janna Michaeli, Shira Mandel, Shelly Maximov, Jonathan Zazoun, Paola Savoia, Nimmi Kothari, Thomas Valmont, Livia Ferrari, Leonard R. Duncan, Stephen Hawser, Moshe Cohen-Kutner, Niv Bachnoff
Summary: This study demonstrates the potent antimicrobial activity of the novel peptide OMN6 against multidrug-resistant Acinetobacter baumannii and its ability to avoid resistance development. In vivo experiments show that OMN6 is highly effective in treating life-threatening infections caused by multidrug-resistant A. baumannii.
Article
Immunology
Zeinab Ezzeddine, Ghassan Ghssein
Summary: The increasing bacterial resistance caused by antibiotic overuse has led to the search for new antimicrobial strategies. Metallophores, which are metal chelators synthesized and produced by bacteria to facilitate metal uptake, are studied for their potential in developing new therapeutics against infectious diseases. This article highlights the perspectives and approaches for the application of metallophores in antimicrobial therapy.
MICROBIAL PATHOGENESIS
(2023)
Article
Infectious Diseases
Paula Rodriguez-Molinoa, Isabel Mellado Sola, Jaime Gutierrez del Alamo Lopez, Fernando Baquero-Artigao, Mariana Diaz-Almirone, David Moreno-Perez, Cristina Calvo, Luis Escosa-Garcia
Summary: The aim of this study was to examine the duration of antibiotic therapy among Spanish paediatricians and compare it with guidelines. The survey showed that 40.8% of respondents used antibiotics for longer than recommended, while 16% used them for shorter durations. This study revealed a notable tendency among paediatricians to prescribe antibiotics for longer than recommended, highlighting various opportunities for improvement.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Chemistry, Medicinal
Sahar Serajian, Ehsan Ahmadpour, Sonia M. Rodrigues Oliveira, Maria de Lourdes Pereira, Siamak Heidarzadeh
Summary: The development of gene editing tools such as ZFNs, TALENs, Cas9, and HEs has led to significant advancements in the field of science, especially with the potential help of the CRISPR system in finding targets for antimicrobials. In the context of combating multi-drug resistant strains, CRISPR provides hope for the diagnosis and treatment of infectious diseases.
Article
Infectious Diseases
Katia Iskandar, Jayaseelan Murugaiyan, Dalal Hammoudi Halat, Said El Hage, Vindana Chibabhai, Saranya Adukkadukkam, Christine Roques, Laurent Molinier, Pascale Salameh, Maarten Van Dongen
Summary: The history and challenges of antibiotic discovery, as well as the need for diversity and innovation in tackling antimicrobial resistance (AMR), are described in this review. It emphasizes the public health concerns of acquired resistance caused by anthropogenic use of antibiotics and the global spread of AMR at an alarming rate. The lack of new leads in the current pipeline and the need to address resistance to old and novel antibiotics are also highlighted.