期刊
EXPERT OPINION ON PHARMACOTHERAPY
卷 9, 期 4, 页码 551-560出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14656566.9.4.551
关键词
amphotericin B; Cryptococcus gattii; Cryptococcus neoformans; fluconazole; fungal infection; HIV infection; posaconazole; voriconazole
资金
- NIAID NIH HHS [K08AI63084, T32 AI007061] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [K08AI063084, T32AI007061] Funding Source: NIH RePORTER
The significance of cryptococcal infection as a cause of human disease has dramatically evolved in recent: years. The objective of this study was to outline the worldwide significance of cryptococcosis and review developments in the management of cryptococcal meningitis. Cryptococcus neoformans var. grubii remains an important cause of disease, particularly in hosts with acquired immunosuppression. Cryptococcus gattii, on the other hand, infects hosts with seemingly normal immune systems and a recent dramatic outbreak in a new ecologic environment highlights the emerging clinical significance of this fungal pathogen. The introduction of new antifungal agents and the adoption of strategies for controlling elevated intracranial pressure in cryptococcal meningitis have added to our therapeutic options. However, the mortality from this infection remains unacceptably high and we are faced with the specific challenges in the management of this disease.
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