Article
Medicine, General & Internal
Karolina M. Andralojc, Duaa Elmelik, Menno Rasing, Bernard Pater, Albert G. Siebers, Ruud Bekkers, Martijn A. Huynen, Johan Bulten, Diede Loopik, Willem J. G. Melchers, William P. J. Leenders
Summary: This study examined the potential of ciRNAseq-testing on cervical scrapes to identify hrHPV-positive women at risk of having or developing high-grade CIN. By detecting gene expression data and applying machine learning, the risk of CIN can be calculated. Further improvement in the model to increase specificity is warranted in larger cohorts.
Article
Pathology
Ruichao Chen, Renchao Zhang, Minfen Zhang, Shaoyan Liu, Mingyu Xie, Zhongfeng Yang, Quan Shi, Hui Chen, Hanzhen Xiong, Na Wang, Qingping Jiang
Summary: This study aimed to explore strategies for grading CINs. Through investigating 85 lesions of CIN 1, 2, or 3, the study found that the expression patterns of HPV RNA signals were different in different CIN lesions. Based on these patterns, it can help pathologists correctly grade CIN.
DIAGNOSTIC PATHOLOGY
(2023)
Article
Oncology
Susanne K. Kjaer, Christian Dehlendorff, Federica Belmonte, Louise Baandrup
Summary: The study demonstrates high effectiveness of HPV vaccination against cervical cancer in females vaccinated under the age of 20, while indicating a lack of immediate effect in those vaccinated between 20-30 years old, emphasizing the importance of early age vaccination.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2021)
Article
Public, Environmental & Occupational Health
Philip E. Castle, Brian Befano, Mark Schiffman, Nicolas Wentzensen, Thomas Lorey, Nancy Poitras, Marianne Hyer, Li C. Cheung
Summary: This study compared the risks of cervical intraepithelial neoplasia grade 2 (CIN2) or more severe diagnoses (CIN2+) between women living with HIV (WLWH) and women not known to have HIV (HIV[-]) following cervical cancer screening. WLWH were more likely to test HPV positive and have abnormal cytology compared to HIV[-] women. The results suggest that both populations could be managed similarly once the screening results are known.
PREVENTIVE MEDICINE
(2022)
Article
Medicine, General & Internal
Sarah J. Bowden, Triada Doulgeraki, Emmanouil Bouras, Georgios Markozannes, Antonios Athanasiou, Harriet Grout-Smith, Konstantinos S. Kechagias, Laura Burney Ellis, Verena Zuber, Marc Chadeau-Hyam, James M. Flanagan, Konstantinos K. Tsilidis, Ilkka Kalliala, Maria Kyrgiou
Summary: Persistent HPV infection is necessary but not sufficient for cervical cancer. Behavioral, environmental, or comorbid exposures may affect the development of cervical cancer. However, the validity of the observational studies describing these associations is still unclear.
Article
Infectious Diseases
Hong-Fang Zhi, Liu-Feng Yang, Jing Ge, Xuan-Tao Yang
Summary: This study analyzed the status of human papillomavirus (HPV) infections in women in Yunnan, China and their correlation with the grade of cervical intraepithelial neoplasia (CIN). The study found that HPV infection in Yunnan was dominated by single infection and high-risk HPV types. Patients aged 30 to 45 years had a higher incidence of high-grade squamous intraepithelial lesions (HSIL), and the most common high-risk HPV subtypes were HPV16, HPV58, and HPV52.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Oncology
Lu Zhang, Qing Wang, Hongwei Zhang, Yu Xie, Long Sui, Qing Cong
Summary: This study retrospectively analyzed the screening history of vaginal intraepithelial neoplasia (VaIN) and vaginal cancer in women diagnosed between 1 January 2019 and 31 December 2019. The results showed that hrHPV test positivity was significantly higher than cytology for VaIN, although there was no significant difference in detecting vaginal cancer between the two tests. Additionally, combining cytology with hrHPV improved detection accuracy for VaIN and vaginal cancer cases up to 95% in both groups.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Yuehui Su, Yingcui Zhang, Yutong Tong, Luoman Zhang, Panpan Li, Huiping Zhang, Xiaodong Zhang, Yujie Tang, Lihong Qin, Yan Shen, Bingjie Wang, Yingying Zhou, Lili Cao, Mengzhen Zhang, Ting Zhang
Summary: 5-ALA-PDT is a non-invasive, effective, and safe therapy for treating CIN & VAIN. However, its efficacy is relatively poor in patients with endocervical canal lesions involvement, atypical vessels, and HPV16/18 and other hrHPV infection.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Oncology
Yi Chen, Ying Xu, Zhengrong Zhang, Zhenhong Xiong, Dan Wu
Summary: This study shows that ALA-PDT is effective in treating HPV-infected CIN and promotes HPV clearance. The HPV clearance rate and LSIL reversal rate in the ALA-PDT group are significantly higher compared to the laser therapy group. There are no significant differences in treatment outcomes based on lesion location and different HPV types, but partially visible transformation zones have lower HPV negative conversion rate and LSIL residual/recurrence rate. The control group has a higher incidence of complications compared to the experimental group.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Oncology
Huihui Cai, Yanci Che, Xin Sun, Xiao Yu, Fengsheng Yu, Feng Hou, Yankui Wang, Tingting Ma
Summary: Five-aminolaevulinic acid photodynamic therapy (ALA-PDT) is an effective treatment for cervical intraepithelial neoplasia 2 (CIN 2), achieving a total response rate of 90.77%. Immune responses play a significant role in the prognosis of the disease.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Oncology
Tudi Chen, Han Deng, Yujie Fu, Wanxing Zhao, Pinglu Li, Jiao Peng, Huiping Wang, Shuping Hou
Summary: Vulvar intraepithelial neoplasia (VIN) is a precancerous lesion on the vulvar epidermis that does not invade or metastasize. Surgery is often risky and destructive as a treatment for VIN. Photodynamic therapy (PDT) is recommended as a new alternative treatment for VIN.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Oncology
Chaohui Bao, Na An, Hong Xie, Ling Xu, Boping Zhou, Jun Luo, Wanqiu Huang, Jian Huang
Summary: By conducting whole-exome sequencing and systematic bioinformatics analysis, we identified C>T transitions in both CINs and CCs, with significantly higher somatic mutations in CCs compared to CINs. Additionally, potential driver genes were identified and new neoantigens were found, providing a solid foundation for further research on the pathogenesis of CC and the development of novel immunotherapeutic approaches.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marina Dudea-Simon, Dan Mihu, Laura Ancuta Pop, Razvan Ciortea, Andrei Mihai Malutan, Doru Diculescu, Cristina Alexandra Ciocan, Roxana Maria Cojocneanu, Vasile Simon, Carmen Bucuri, Radu Mocan-Hognogi, Cornelia Braicu, Ioana Berindan-Neagoe
Summary: Cervical cancer is a common and deadly form of cancer in women. Detecting the precursor, CIN, can prevent cervical cancer. This study found that certain genes, such as MEG3, DAPK1, MLH1, MALAT1, TIMP3, and SOX1, had abnormal expression levels in both CIN and cancer samples compared to normal samples. Lower expression of MEG3 and miR-205-5p could serve as early warning signals for the development of invasive cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Huei-Jean Huang, Hsiu-Jung Tung, Lan-Yan Yang, Angel Chao, Yun-Hsin Tang, Hung-Hsueh Chou, Wei-Yang Chang, Ren-Chin Wu, Chu-Chun Huang, Chiao-Yun Lin, Min-Jie Liao, Wei-Chun Chen, Cheng-Tao Lin, Min-Yu Chen, Kuan-Gen Huang, Chin-Jung Wang, Ting-Chang Chang, Chyong-Huey Lai
Summary: This observational study investigated the long-term outcomes and HPV genotype changes after conization for high-grade cervical intraepithelial neoplasia (HG-CIN). Results showed that active surveillance may reduce the severity of progression to cancer, and a majority of patients with recurrent CIN2+ had persistent type-specific HPV infections. Effective therapeutic vaccines for such cases are still needed.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Microbiology
Jason K. W. Yap, Sean T. Kehoe, Ciaran B. J. Woodman, Christopher W. Dawson
Summary: EGCG treatment inhibits keratinocyte proliferation by degrading E6 and E7 oncoproteins, has little impact on cell differentiation, and suppresses the expression of late viral protein E4, indicating its ability to block productive viral replication.