Increased antileukemic effects in human acute myeloid leukemia by combining HSP70 and HSP90 inhibitors

The Possible Diagnostic and Prognostic Use of Systemic Chemokine Profiles in Clinical Medicine—The Experience in Acute Myeloid Leukemia from Disease Development and Diagnosis via Conventional Chemotherapy to Allogeneic Stem Cell Transplantation

(2013) Håkon Reikvam et al.   Toxins

The nuclear factor erythroid 2-like 2 activator, tert-butylhydroquinone, improves cognitive performance in mice after mild traumatic brain injury

(2012) J.N. Saykally et al.   NEUROSCIENCE

Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia

(2012) Jay P. Patel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acute myeloid leukemia: 2012 update on diagnosis, risk stratification, and management

(2011) Elihu H. Estey   AMERICAN JOURNAL OF HEMATOLOGY

Acute myeloid leukaemia in the elderly: a review

(2011) Daniel A. Pollyea et al.   BRITISH JOURNAL OF HAEMATOLOGY

Expression profile of heat shock proteins in acute myeloid leukaemia patients reveals a distinct signature strongly associated with FLT3 mutation status - consequences and potentials for pharmacological intervention

(2011) Håkon Reikvam et al.   BRITISH JOURNAL OF HAEMATOLOGY

Targeting HSP70: The second potentially druggable heat shock protein and molecular chaperone?

(2011) Marissa V. Powers et al.   CELL CYCLE

Phase I and pharmacological study of cytarabine and tanespimycin in relapsed and refractory acute leukemia

(2011) S. H. Kaufmann et al.   HAEMATOLOGICA

Pan-histone deacetylase inhibitor panobinostat depletes CXCR4 levels and signaling and exerts synergistic antimyeloid activity in combination with CXCR4 antagonists

(2010) A. Mandawat et al.   BLOOD

Death by chaperone: HSP90, HSP70 or both?

(2010) Marissa V. Powers et al.   CELL CYCLE

Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia

(2010) J E Lancet et al.   LEUKEMIA

Reduced Mortality after Allogeneic Hematopoietic-Cell Transplantation

(2010) Ted A. Gooley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

(2009) H. Dohner et al.   BLOOD

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

(2009) Andrew J. Massey et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Heat Shock Protein 90 – a Potential Target in the Treatment of Human Acute Myelogenous Leukemia

(2009) H. Reikvam et al.   CURRENT CANCER DRUG TARGETS

Targeted therapy in acute myeloid leukaemia: current status and future directions

(2009) Camilla Stapnes et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Novel Adenosine-Derived Inhibitors of 70 kDa Heat Shock Protein, Discovered Through Structure-Based Design†

(2009) Douglas S. Williamson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Clinical correlation of circulating heat shock protein 70 in acute leukemia

(2009) Chen-Hsiung Yeh et al.   LEUKEMIA RESEARCH

SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK

(2008) Y. Okawa et al.   BLOOD

Heat shock protein 90 inhibition is cytotoxic to primary AML cells expressing mutant FLT3 and results in altered downstream signalling

(2008) Laila Al Shaer et al.   BRITISH JOURNAL OF HAEMATOLOGY

Primary human acute myeloid leukaemia cells increase the proliferation of microvascular endothelial cells through the release of soluble mediators

(2008) Kimberley Hatfield et al.   BRITISH JOURNAL OF HAEMATOLOGY

Dual Targeting of HSC70 and HSP72 Inhibits HSP90 Function and Induces Tumor-Specific Apoptosis

(2008) Marissa V. Powers et al.   CANCER CELL

Significance of heat-shock protein (HSP) 90 expression in acute myeloid leukemia cells

(2008) Pascale Flandrin et al.   CELL STRESS & CHAPERONES