Targeting voltage-gated calcium channels for the treatment of neuropathic pain: a review of drug development

Recent Updates of N-Type Calcium Channel Blockers with Therapeutic Potential for Neuropathic Pain and Stroke

(2012) Takashi Yamamoto et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Role of voltage-dependent calcium channel subtypes in spinal long-term potentiation of C-fiber-evoked field potentials

(2011) Soichiro Ohnami et al.   PAIN

Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states

(2011) Amin Boroujerdi et al.   PAIN

A potent and selective indole N-type calcium channel (Cav2.2) blocker for the treatment of pain

(2010) Sriram Tyagarajan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ziconotide Combination Intrathecal Therapy: Rationale and Evidence

(2010) Mark S. Wallace et al.   CLINICAL JOURNAL OF PAIN

EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision

(2010) N. Attal et al.   EUROPEAN JOURNAL OF NEUROLOGY

Analgesic Effects of a Substituted N-Triazole Oxindole (TROX-1), a State-Dependent, Voltage-Gated Calcium Channel 2 Blocker

(2010) C. Abbadie et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Recommendations for the Pharmacological Management of Neuropathic Pain: An Overview and Literature Update

(2010) Robert H. Dworkin et al.   MAYO CLINIC PROCEEDINGS

N-type Calcium Channel Blocker for Pain Treatment

(2010) Jianren Mao   PAIN MEDICINE

Intrathecal Ziconotide for Severe Chronic Pain: Safety and Tolerability Results of an Open-Label, Long-Term Trial

(2009) Mark S. Wallace et al.   ANESTHESIA AND ANALGESIA

A Fluorescence-Based High-Throughput Screening Assay for the Identification of T-Type Calcium Channel Blockers

(2009) Francesco Belardetti et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Suppression of Formalin-Induced Nociception by Cilnidipine, a Voltage-Dependent Calcium Channel Blocker

(2009) Hajime Koganei et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

ω-Conotoxin GVIA mimetics based on an anthranilamide core: Effect of variation in ammonium side chain lengths and incorporation of fluorine

(2009) Asa Andersson et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Scaffold-based design and synthesis of potent N-type calcium channel blockers

(2009) Gerald W. Zamponi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Drugs from slugs—Past, present and future perspectives of ω-conotoxin research

(2009) Jon-Paul Bingham et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Analgesic  -Conotoxins CVIE and CVIF Selectively and Voltage-Dependently Block Recombinant and Native N-Type Calcium Channels

(2009) G. Berecki et al.   MOLECULAR PHARMACOLOGY

CNSB004 (Leconotide) Causes Antihyperalgesia Without Side Effects When Given Intravenously: A Comparison with Ziconotide in a Rat Model of Diabetic Neuropathic Pain

(2009) Anton Kolosov et al.   PAIN MEDICINE

Intrathecal Ziconotide for Neuropathic Pain: A Review

(2009) Richard L. Rauck et al.   Pain Practice

The structure–activity relationship study on 2-, 5-, and 6-position of the water soluble 1,4-dihydropyridine derivatives blocking N-type calcium channels

(2008) Takashi Yamamoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Integrating the discovery pipeline for novel compounds targeting ion channels

(2008) Grzegorz Bulaj   CURRENT OPINION IN CHEMICAL BIOLOGY

Analgesic activity of ZC88, a novel N-type voltage-dependent calcium channel blocker, and its modulation of morphine analgesia, tolerance and dependence

(2008) Ge Meng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ziconotide: an update and review

(2008) Jason A Williams et al.   EXPERT OPINION ON PHARMACOTHERAPY

Upregulation of the T-Type Calcium Current in Small Rat Sensory Neurons After Chronic Constrictive Injury of the Sciatic Nerve

(2008) Miljen M. Jagodic et al.   JOURNAL OF NEUROPHYSIOLOGY

Long-Term Intrathecal Ziconotide for Chronic Pain: An Open-Label Study

(2008) Lynn R. Webster et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Zonisamide Suppresses Pain Symptoms of Formalin-Induced Inflammatory and Streptozotocin-Induced Diabetic Neuropathy

(2008) Mitsuo Tanabe et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Phase II, Open-Label, Multicenter Study of Combined Intrathecal Morphine and Ziconotide: Addition of Ziconotide in Patients Receiving Intrathecal Morphine for Severe Chronic Pain

(2007) Mark S. Wallace et al.   PAIN MEDICINE