期刊
EXPERT OPINION ON INVESTIGATIONAL DRUGS
卷 18, 期 4, 页码 501-508出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/13543780902852560
关键词
antineoplastic drugs; belinostat; HDAC; histone deacetylase inhibitors; review
Belinostat is a potent hydroxamate-type histone deacetylase inhibitor with a broad antineoplastic activity in a spectrum of preclinical tumor models and with demonstrated clinical efficacy in the still very early clinical trial program. Belinostat has been relatively well tolerated following both i.v. (from 30-min daily infusion to 48-h continuous infusion) and oral administration, and, since no or only minor bone marrow toxicity has been encountered, it has combined well with other antineoplastic agents in full doses. The clinical trial program needs to be advanced further before the final position of belinostat in the therapeutic anticancer armamentarium can be determined.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据