Article
Medicine, General & Internal
Jose Alberto Navarro-Garcia, Rafael Salguero-Bodes, Laura Gonzalez-Lafuente, Laura Martin-Nunes, Elena Rodriguez-Sanchez, Teresa Bada-Bosch, Eduardo Hernandez, Evangelina Merida-Herrero, Manuel Praga, Jorge Solis, Fernando Arribas, Hector Bueno, Makoto Kuro-O, Maria Fernandez-Velasco, Luis Miguel Ruilope, Carmen Delgado, Gema Ruiz-Hurtado
Summary: This study found that the FGF23-Klotho axis is associated with cardiac arrhythmias in CKD patients. The increase in FGF23 levels in CKD patients is related to prolonged QT intervals. Experimental results show that FGF23 can induce QT prolongation in healthy mice. This prolongation and changes in cardiac repolarization were also observed in Nfx mice and Klotho deficient mice.
Article
Cardiac & Cardiovascular Systems
Koichi Kato, Holly M. Isbell, Veronique Fressart, Isabelle Denjoy, Amal Debbiche, Hideki Itoh, Jacques Poinsot, Alfred L. George, Alain Coulombe, Madeline A. Shea, Pascale Guicheney
Summary: This study identified a novel CALM3 variant, p.N138K, associated with LQTS and compared its pathogenicity with a severe LQTS phenotype associated with p.D130G-CaM variant. The p.N138K variant impairs Ca2+-binding affinity of CaM and I-CaL inactivation but potentiates I-Ks. The variable clinical phenotype of this variant compared with previously published de novo LQTS-CaM variants can be explained by a milder impairment of I-CaL inactivation combined with I-Ks augmentation.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Francesco Luzza, Rosalba De Sarro, Roberto Licordari, Pasquale Crea, Pietro Pugliatti, Giuseppe Certo, Lorenzo Pistelli, Francesca Campanella, Maria Claudia Lo Nigro, Matteo Casale, Michele Correale, Giuseppe Dattilo
Summary: QT interval varies with heart rate and needs to be corrected. Atrial fibrillation (AF) is associated with elevated heart rate and beat-to-beat variation. The study aims to find the best correlation between QTc in AF and restored sinus rhythm (SR) and determine the best correction formula and method for determining QTc in AF. The results show that Bazzett's formula is the least accurate in estimating QTc during AF.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Physiology
Songwen Chen, Guannan Meng, Anisiia Doytchinova, Johnson Wong, Susan Straka, Julie Lacy, Xiaochun Li, Peng-Sheng Chen, Thomas H. Everett
Summary: The study found that compared to healthy volunteers, patients with heart disease had a greater increase in QTc interval and STVQT during SKNA bursts. SKNA bursts were associated with an increase in STVQT, suggesting a potential relationship with arrhythmias.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Neha Mantri, Meng Lu, Jonathan G. Zaroff, Neil Risch, Thomas Hoffmann, Akinyemi Oni-Orisan, Catherine Lee, Eric Jorgenson, Carlos Iribarren
Summary: This study tracked 61,455 members of an integrated healthcare delivery system in Northern California and found an association between Long QT syndrome and the risk of cardiovascular disease and all-cause mortality. The results demonstrate that longitudinal information from serial ECGs can improve the ability to predict cardiovascular disease outcomes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Pharmacology & Pharmacy
Erika N. Titus-Lay, Heather A. Jaynes, Elena Tomaselli Muensterman, Carol A. Ott, Todd A. Walroth, Gabriela Williams, Paul R. Moe, Michelle Wilbrandt, James E. Tisdale
Summary: The study aimed to assess the accuracy of a handheld smartphone ECG for QT measurement in patients on maintenance methadone therapy, showing that the iECG is accurate and moderately good for identifying patients with methadone-associated QTc prolongation.
Article
Cardiac & Cardiovascular Systems
Joanna Fishbein, Kristie M. Coleman, Amarbir Bhullar, Nikhil Sharma, Stefanos Zafeiropoulos, Umair Ansari, Tia Bimal, Yan Liu, Stavros E. Mountantonakis
Summary: This study retrospectively analyzed COVID-19 patients and identified independent factors associated with in-hospital mortality, which were incorporated into a risk score for prediction.
Article
Biochemistry & Molecular Biology
Gonzalo Ferreira, Axel Santander, Romina Cardozo, Luisina Chavarria, Lucia Dominguez, Nicolas Mujica, Milagros Benitez, Santiago Sastre, Luis Sobrevia, Garth L. Nicolson
Summary: Inwardly rectifying potassium (Kir) channels are important for maintaining membrane potential and potassium homeostasis. These channels have various subtypes and can be regulated by molecules found in nutrients, such as phosphoinositols, polyamines, and Mg2+. Changes in Kir channels can affect metabolism and the ability to absorb nutrients and electrolytes. The study of nutrigenomics of ion channels is crucial for understanding how diet and nutrients can impact ion channel function, expression, and lead to pathological conditions that affect diet and electrolyte intake.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Pharmacology & Pharmacy
Xiao-Yu Liu, Ling-Ling Qian, Ru-Xing Wang
Summary: This review summarizes the role of hydrogen sulfide (H2S) in the regulation of vascular tone, specifically through its interaction with different vascular potassium channels. Studies have shown that H2S plays a key role in the pathophysiology of vascular diseases and physiological vascular homeostasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Roi Bar Cohen, Matthew Dai, Anthony Aizer, Chirag Barbhaiya, Connor Peterson, Scott Bernstein, David S. Park, Michael Spinelli, Larry A. Chinitz, Lior Jankelson
Summary: The QTc/JTc interval is significantly and independently prolonged after sudden cardiac arrest, regardless of known QT prolonging triggers. Normalization of the QTc is expected only after day 6 of hospitalization. Assessment of the QTc for determining the etiology of arrest or monitoring the effect of QT prolonging medications may be unreliable.
Article
Cardiac & Cardiovascular Systems
Victor Nauffal, Valerie N. Morrill, Sean J. Jurgens, Seung Hoan Choi, Amelia W. Hall, Lu-Chen Weng, Jennifer L. Halford, Christina Austin-Tse, Christopher M. Haggerty, Stephanie L. Harris, Eugene K. Wong, Alvaro Alonso, Dan E. Arking, Emelia J. Benjamin, Eric Boerwinkle, Yuan- Min, Adolfo Correa, Brandon K. Fornwalt, Susan R. Heckbert, Charles Kooperberg, Henry J. Lin, Ruth J.f. Loos, Kenneth M. Rice, Namrata Gupta, Thomas W. Blackwell, Braxton D. Mitchell, Alanna C. Morrison, Bruce M. Psaty, Wendy S. Post, Susan Redline, Heidi L. Rehm, Stephen S. Rich, Jerome I. Rotter, Elsayed Z. Soliman, Nona Sotoodehnia, Kathryn L. Lunetta, Patrick T. Ellinor, Steven A. Lubitz
Summary: Using data from large-scale biorepositories, this study found 54 independent loci associated with cardiac repolarization, including 21 novel loci. The findings suggest that both rare variants in genes underlying cardiac repolarization and polygenic risk play a role in determining the duration of QT interval in the population.
Review
Biochemistry & Molecular Biology
Monika Richter-Laskowska, Paulina Trybek, Domenico Vittorio Delfino, Agata Wawrzkiewicz-Jalowiecka
Summary: Potassium channels are integral proteins responsible for the transport of K+ ions through biological membranes. They are important drug targets due to their physiological roles in membrane potential regulation and cell signaling. Flavonoids, a group of biologically active substances found in plants, have been shown to modulate potassium channels and exert beneficial effects on human health. This article presents the current knowledge on the modulation of potassium channels by flavonoids and discusses the potential implications of these changes. It also suggests future research directions in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Wenjing Zhang, Yu Liang, Jia Lv, Yan Li, Jiping Sun
Summary: A study was conducted on QT interval and QTc changes in ESRD patients undergoing peritoneal dialysis. The results showed that patients undergoing peritoneal dialysis had a lower risk of arrhythmias and improvements in clinical and biochemical indexes.
Article
Biochemistry & Molecular Biology
Hui Xue, Yuexin Li, Zhengrong Zhao, Jiacheng Ren, Wenting Yu, Fang Wang, Xianghua Li, Jiaxin Li, Qianqian Xia, Yuxin Zhang, Baoxin Li
Summary: This study explored the mechanism of hypoxia-induced LQTS and found that deacetylation of hERG gene-associated histones and hERG protein could be the mechanisms for LQTS. Inhibition of HDAC1, HDAC2, and HDAC6 could be a promising reversal strategy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Pharmacology & Pharmacy
Hugo M. Vargas, Michael G. Rolf, Todd A. Wisialowski, William Achanzar, Anthony Bahinski, Alan Bass, Charles T. Benson, Khuram W. Chaudhary, Nicolas Couvreur, Corina Dota, Michael J. Engwall, C. Michael Foley, David Gallacher, Andrea Greiter-Wilke, Jean-Michel Guillon, Brian Guth, Herbert M. Himmel, Christa Hegele-Hartung, Maki Ito, Stephen Jenkinson, Katsuyoshi Chiba, Armando Lagrutta, Paul Levesque, Eric Martel, Yoshiko Okai, Ravikumar Peri, Amy Pointon, Yusheng Qu, Ard Teisman, Martin Traebert, Takashi Yoshinaga, Gary A. Gintant, Derek J. Leishman, Jean-Pierre Valentin
Summary: Efficient assessment of drug-induced QTc prolongation remains a concern of drug developers and regulators worldwide. While successful, nonclinical evaluations currently have minimal impact on clinical QTc prolongation assessment. Fully integrating nonclinical and clinical data can simplify drug development processes.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)