Article
Gastroenterology & Hepatology
Neeraj Narula, Emily C. L. Wong, John K. Marshall, Jean-Frederic Colombel, Parambir S. Dulai, Walter Reinisch
Summary: For patients with moderate to severe biologic naive UC, infliximab and vedolizumab have similar efficacy in improving clinical symptoms, but infliximab has higher rates of corticosteroid-free clinical remission (CR) and endoscopic remission (ER) after 1 year of treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jill L. Kinzer, Troy A. Halseth, Jukyung Kang, Sang Yeop Kim, Preethi Kumaran, Michael Ford, Sergei Saveliev, St John Skilton, Anna Schwendeman
Summary: FDA-approved anti-TNF alpha biopharmaceuticals have been successful in treating autoimmune diseases, but there are product-specific differences in patient outcomes, possibly due to structural and functional differences. In this study, we compared the structural and functional differences among three anti-TNF alpha mAbs (Humira (R), Remicade (R), and Simponi Aria (R)) to understand their implications on efficacy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Gastroenterology & Hepatology
Rahul S. Dalal, Emma L. McClure, Jenna Marcus, Jessica R. Allegretti
Summary: This study compared the long-term drug survival of vedolizumab, adalimumab, and infliximab in patients with ulcerative colitis (UC). The results showed that vedolizumab had better survival rates than adalimumab for both clinical response and adverse effects, and vedolizumab also had better survival rates than infliximab for adverse effects.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jose M. Huguet, Victor Garcia-Lorenzo, Lidia Marti, Jose Maria Paredes, Jose Joaquin Ramirez, Miguel Pastor, Lucia Ruiz, Ana Sanahuja, Pilar Timoneda, Laura Sanchis, Gloria Alemany Perez, Marta Maia Bosca-Watts
Summary: This study evaluated the efficacy and safety of subcutaneous infliximab in patients with inflammatory bowel disease. The results showed that subcutaneous administration of infliximab has the potential to maintain treatment stability and increase drug levels. This is of great significance for the management of patients with inflammatory bowel disease.
Article
Pharmacology & Pharmacy
Beatriz Orts, Ana Gutierrez, Lucia Madero, Laura Sempere, Ruben Frances, Pedro Zapater
Summary: There are differences in the immunological profile and clinical evolution of patients with Crohn's disease according to the anti-TNF dose and serum trough levels.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Gastroenterology & Hepatology
Edo H. J. Savelkoul, Pepijn W. A. Thomas, Lauranne A. A. P. Derikx, Nathan den Broeder, Tessa E. H. Romkens, Frank Hoentjen
Summary: Loss of response to infliximab or adalimumab in ulcerative colitis occurs frequently, with an annual rate of 10% for infliximab and 13% for adalimumab. Dose escalation rates were higher than loss of response, with 72% and 52% regaining clinical benefit for infliximab and adalimumab, respectively. Uniform definitions are needed for more robust evaluations.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Yoram Bouhnik, Guillaume Pineton de Chambrun, Jerome Lambert, Maria Nachury, Philippe Seksik, Romain Altwegg, Lucine Vuitton, Carmen Stefanescu, Stephane Nancey, Alexandre Aubourg, Melanie Serrero, Jerome Filippi, Kristell Desseaux, Stephanie Viennot, Vered Abitbol, Madina Boualit, Arnaud Bourreille, Cyrielle Giletta, Anthony Buisson, Xavier Roblin, Nina Dib, Georgia Malamut, Aurelien Amiot, Mathurin Fumery, Edouard Louis, Yasmine Elgharabawy, Laurent Peyrin-Biroulet, MICA GETAID Study Grp
Summary: The management of intra-abdominal abscesses complicating Crohn's disease is challenging, and surgery with delayed intestinal resection is often recommended. This study found that careful management of abscesses before initiating treatment with adalimumab can lead to high efficacy in both short and long term outcomes for biologic-naive patients with Crohn's disease complicated by an intra-abdominal abscess.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Alix Demaris, Ella S. K. Widigson, Johan F. K. F. Ilvemark, Casper Steenholdt, Jakob B. Seidelin, Wilhelm Huisinga, Robin Michelet, Linda B. S. Aulin, Charlotte Kloft
Summary: This review aims to analyze the population PK models of infliximab (IFX) in patients with ulcerative colitis (UC) and acute severe UC (ASUC), and assess the impact of disease activity on IFX PK. The results showed that there are still many gaps in the current research, such as a limited number of models specifically developed for UC patients, a lack of studies on severe UC patients, and a lack of evaluation of predictive performance for the models. Therefore, more comprehensive research and adequate reporting and evaluation of the models are needed for clinical application.
Article
Gastroenterology & Hepatology
Thomas X. Lu, Matthew Dapas, Erika Lin, Trevor Peters, Atsushi Sakuraba
Summary: In this meta-analysis of randomized controlled studies, patients with IBD who took PPIs were less likely to achieve remission while on infliximab therapy. Further investigation into the effect of PPIs on IBD outcomes and therapies is warranted based on our study's results.
Article
Gastroenterology & Hepatology
Rachel Levy, Manar Matar, Maya Zvuloni, Raanan Shamir, Amit Assa
Summary: TC response to adjustment of anti-TNFa treatment can be predicted for adalimumab but not for infliximab. Decreasing interval for adalimumab results in increased TC, while increasing interval for adalimumab and dose increase for infliximab both lead to decreased TC.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Review
Gastroenterology & Hepatology
Cindy C. Y. Law, Bryce Tkachuk, Stephen Lieto, Neeraj Narula, Samantha Walsh, Jean-Frederic Colombel, Ryan C. Ungaro
Summary: Early biologic treatment is associated with lower rates of surgery in patients with Crohn's disease, while it appears to be associated with higher rates of colectomy in patients with ulcerative colitis, which may be confounded by disease severity.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Emily C. L. Wong, Shahin Merat, Cristina Monaco, Parambir S. Dulai, Vipul Jairath, John K. Marshall, Walter Reinisch, Neeraj Narula
Summary: In this post-hoc analysis, infliximab showed superior efficacy over tofacitinib for the treatment of moderate to severe biologic-naive UC. However, baseline characteristic mismatches persisted despite propensity score matching, and further studies are needed to confirm these findings.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Immunology
Chenglin Ye, Sizhe Zhu, Jingping Yuan
Summary: This study analyzed the gene expression profiles of patients with Crohn's disease (CD) and identified two gene subtypes: immune and metabolic. The immune subtype was associated with leukocyte migration and cytokine interactions, while the metabolic subtype was associated with metabolic pathways. The combination of interleukin 1 beta, interleukin 6, and Toll-like receptor 4 effectively distinguished between these two gene subtypes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yong Il Lee, Yehyun Park, Soo Jung Park, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
Summary: In this study, infliximab and adalimumab showed similar treatment efficacy and long-term outcomes in biologic-naive patients with moderate to severe UC. The analysis revealed that an elevated C-reactive protein level (>5 mg/L) was a significant predictive factor for poor outcomes in these patients.
Article
Gastroenterology & Hepatology
Ruby Greywoode, Francesca Petralia, Thomas A. Ullman, Jean Frederic Colombel, Ryan C. Ungaro
Summary: Racial minority groups showed lower rates of clinical response, clinical remission, and endoscopic healing in golimumab induction and maintenance trials compared to White participants.
INFLAMMATORY BOWEL DISEASES
(2023)