Article
Endocrinology & Metabolism
Xu Huang, Cheng Qin, Xiaoxu Guo, Feng Cao, Chengchun Tang
Summary: This study investigated the relationship between HbA1c and the incidence of hypertension in a large prospective cohort. The findings suggest that HbA1c is linearly and positively associated with the risk of hypertension, particularly in female, lower education level, and non-obese subgroups. HbA1c can be considered as a predictor for hypertension risk.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jason T. Wiseman, Jeffery Chakedis, Eliza W. Beal, Anghela Paredes, Amy McElhany, Andrew Fang, Andrei Manilchuk, Christopher Ellison, George Van Buren, Timothy M. Pawlik, Carl R. Schmidt, William E. Fisher, Mary Dillhoff
Summary: This study found that preoperative levels of HbA1c and blood glucose were associated with the risk of developing new IDDM after pancreatic resection. By setting predictive cutoffs at HbA1c of 6.25% and glucose of 121 mg/dL, high-risk patients can be accurately identified. Patients who developed new IDDM after surgery had higher rates of complications and discharge to nursing facilities.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Endocrinology & Metabolism
Yanli Li, Yan Wu, Yi Shu, Shu Li, Jianhao Pei, Hong Chen, Shiping Liu, Guangda Xiang, Wenbo Wang, Pengfei Shan, Heng Su, Xiaoyan Wu, Dewen Yan, Wangen Li
Summary: Objective: Investigating alternative indices for insulin initiation, besides A1C, in the treatment of type 2 diabetes (T2D). Methods: A cross-sectional survey was conducted on 1034 T2D patients who decided to initiate insulin therapy due to failure of oral antidiabetic drugs. Results: The study found no significant differences in fasting blood glucose (FBG) or postprandial blood glucose (PBG) between patients who were tested for A1C and those who were not. Conclusion: Initiating insulin based on FBG or PBG is a common practice at least in China, and it can be a simple and effective way to overcome clinical inertia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Elizabeth Selvin
Summary: The discovery of HbA(1c) as a measure of average glucose exposure was a significant advancement in diabetes care. It is now widely used for monitoring and diagnosing diabetes due to its convenience, reliability, and standardization. Epidemiologic studies have shown strong links between HbA(1c) and complications, making it a cornerstone in modern diabetes care.
Article
Pharmacology & Pharmacy
Kyle D. Medak, Alyssa J. Weber, Hesham Shamshoum, Greg L. McKie, Margaret K. Hahn, David C. Wright
Summary: This study aimed to determine if increasing endogenous GLP1 is sufficient to protect against acute olanzapine-induced impairments in glucose and lipid homeostasis. The researchers found that pharmacological approaches to increase endogenous GLP1 can reduce lipid and glucose metabolism disturbances caused by olanzapine. These findings suggest that increasing endogenous GLP1 through pharmacological means may be a useful adjunct approach to mitigate olanzapine-induced perturbations in lipid and glucose metabolism.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Amy Darukhanavala, Filia Van Dessel, Jannifer Ho, Megan Hansen, Ted Kremer, David Alfego
Summary: This study aimed to evaluate whether HbA1c is suitable for screening patients with pre-CFRD dysglycemia, and the results showed a lack of association between HbA1c and glycemic states. Further studies are needed to explore more efficient screening methods to reduce the burden of annual OGTTs.
Article
Clinical Neurology
Michel T. Torbey, Qi Pauls, Nina Gentile, Mercedes Falciglia, William Meurer, Creed L. Pettigrew, Valerie L. Durkalski, Thomas Bleck, Askiel Bruno
Summary: This study aimed to evaluate the association between glycemic parameters and 90-day functional outcomes in patients with acute ischemic stroke. The results showed that patients with undiagnosed diabetes had the lowest likelihood of favorable outcomes. However, no relationship was found between any of the glycemic parameters and the rate of favorable outcomes or treatment effects.
Article
Endocrinology & Metabolism
Guanhua Chen, Rui Zhang, Chunlu Tan, Xubao Liu, Lei Yu, Yonghua Chen
Summary: Using HbA1c alone as a diagnostic criterion for diabetes may not be sensitive enough in patients with pancreatic diseases. The optimal values of 5.8% and 6.0% for HbA1c improved the accuracy of diagnosing prediabetes and diabetes and should be considered. Furthermore, combining HbA1c and FPG tests is advocated for diagnosing diabetes in patients with pancreatic diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jen-Hung Huang, Yung-Kuo Lin, Ting-Wei Lee, Han-Wen Liu, Yu-Mei Chien, Yu-Chun Hsueh, Ting- Lee, Yi-Jen Chen
Summary: CGM can predict HbA1c values within 1 month after CGM in patients with DM. MAGE and %CV were strongly correlated with HbA1c values 1 and 2 months after CGM, respectively. Diurnal blood glucose levels were significantly correlated with HbA1c values 1-2 months before and 1 month after CGM.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Endocrinology & Metabolism
Andrew J. Karter, Melissa M. Parker, Howard H. Moffet, Lisa K. Gilliam
Summary: Studies show that African American patients have significantly higher A1C levels than White patients with the same average glucose level, but there is limited knowledge about other racial/ethnic groups. This study found that for African American patients, A1C results overestimated glycemia compared to White patients, while Asians, Latinos, and multiethnic patients had similar A1C levels as White patients. It suggests that A1C results may lead to premature diabetes diagnoses, overtreatment, or inaccurate health disparity assessments.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
Jungchan Park, Ah Ran Oh, Seung-Hwa Lee, Jong-Hwan Lee, Jeong Jin Min, Ji-Hye Kwon, Jihoon Kim, Kwangmo Yang, Jin-Ho Choi, Sang-Chol Lee, Hyeon-Cheol Gwon, Kyunga Kim, Joonghyun Ahn, Sangmin Maria Lee
Summary: The study found that preoperative hyperglycemia was associated with myocardial injury after noncardiac surgery and 30-day mortality, while HbA1c levels were not. Immediate glucose control may be more crucial than long-term control in patients undergoing noncardiac surgery.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Cardiac & Cardiovascular Systems
Bernardo Paz Barboza, Camila Tureck, Liliana Paula Bricarello, Mariane de Almeida Alves, Anabelle Retondario, Amanda de Moura Souza, Ricardo Fernandes, Francisco de Assis Guedes de Vasconcelos
Summary: This systematic review investigated the association between adolescents' dietary patterns and diabetes-related biomarkers. The results showed that the Western dietary pattern was positively associated with fasting insulinemia and insulin resistance, but there was no consistent association with fasting blood glucose.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Rahul Aggarwal, Deepak L. Bhatt, Michael Szarek, Christopher P. Cannon, Darren K. Mcguire, Silvio E. Inzucchi, Renato D. Lopes, Michael J. Davies, Phillip Banks, Bertram Pitt, Philippe Gabriel Steg
Summary: This study assessed the efficacy of Sotagliflozin on heart failure clinical outcomes in individuals with different baseline glycosylated hemoglobin levels. The results showed that Sotagliflozin reduced heart failure outcomes, regardless of baseline HbA1c.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Beatriz Isabel Garcia-Martinez, Mirna Ruiz-Ramos, Jose Pedraza-Chaverri, Edelmiro Santiago-Osorio, Victor Manuel Mendoza-Nunez
Summary: Resveratrol has the potential to improve glucose and insulin levels in patients with type 2 diabetes, with significant improvement in glucose observed at doses of 500-1000 mg/day, and improvement in insulin seen at doses lower than 500 mg/day or greater than 1000 mg/day.
Article
Engineering, Electrical & Electronic
Namho Kim, Da Young Lee, Wonju Seo, Nan Hee Kim, Sung-Min Park
Summary: The study aimed to develop clustering-based personalized models to estimate hemoglobin A1c (HbA1c) levels from continuous glucose monitoring (CGM) values. The proposed models showed improved performance in estimating HbA1c levels and provided real-time integrated information for better glycemic control.
IEEE SENSORS JOURNAL
(2022)
Article
Psychiatry
Celso Arango, Andrea Fagiolini, Philip Gorwood, John M. Kane, Sergio Diaz-Mendoza, Navdeep Sahota, Christoph U. Correll
Summary: This study investigated the use of long-acting injectable antipsychotics (LAIs) in patients with first-episode psychosis (FEP) and early-phase (EP) schizophrenia. The expert consensus concluded that LAIs can decrease the risk of relapse, rehospitalization, and functional dysfunction, and highlighted the potential for multidimensional longer-term functional recovery beyond symptomatic remission.
Review
Psychiatry
Gonzalo Salazar de Pablo, Ana Catalan, Julio Vaquerizo Serrano, Borja Pedruzo, Luis Alameda, Veronica Sandroni, Alvaro Armendariz, Victoria Rodriguez, Celso Arango, Carmen Moreno, Johnny Downs, Chris Abbott, Jae Il Shin, Marco Solmi, Paolo Fusar-Poli, Christoph U. Correll
Summary: This study aims to provide a comprehensive review and meta-analysis of the diagnosis, prognosis, and treatment of negative symptoms in children and adolescents with early-onset psychosis (EOP) and those at clinical high risk for psychosis (CHR-P). The findings indicate that negative symptoms are common in children and adolescents at early stages of psychosis, particularly in those at CHR-P, and are associated with poor outcomes. Therefore, further intervention research is needed to provide evidence-based treatments.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Review
Clinical Neurology
Jose M. M. Rubio, Daniel Guinart, John M. M. Kane, Christoph U. U. Correll
Summary: This systematic review and meta-analysis examined the management strategies for schizophrenia patients with early non-response to antipsychotic treatment. The study found that there is limited evidence and uncertainty regarding the best treatment strategies for early non-response.
Review
Behavioral Sciences
Samuele Cortese, Katherine McGinn, Mikkel Hojlund, Alan Apter, Celso Arango, Immaculada Baeza, Tobias Banaschewski, Jan Buitelaar, Josefina Castro-Fornieles, David Coghill, David Cohen, Edna Grunblatt, Pieter J. Hoekstra, Anthony James, Pia Jeppesen, Peter Nagy, Anne Katrine Pagsberg, Mara Parellada, Antonio M. Persico, Diane Purper-Ouakil, Veit Roessner, Paramala Santosh, Emily Simonoff, Dejan Stevanovic, Argyris Stringaris, Benedetto Vitiello, Susann Walitza, Abraham Weizman, Tamar Wohlfarth, Ian C. K. Wong, Gil Zalsman, Alessandro Zuddas, Carmen Moreno, Marco Solmi, Christoph U. Correll
Summary: In order to identify potential novel medications for child and adolescent mental health problems, we conducted a systematic search on clinical trial databases from 2010 to 2022. We included phase 2 or 3 randomized controlled trials (RCTs) of medications without regulatory approval in the US, Europe or Asia, and also RCTs of dietary interventions/probiotics. We found 234 ongoing or completed RCTs, with varying results on primary outcomes.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Psychology, Clinical
Pavol Mikolas, Michael Marxen, Philipp Riedel, Kyra Broeckel, Julia Martini, Fabian Huth, Christina Berndt, Christoph Vogelbacher, Andreas Jansen, Tilo Kircher, Irina Falkenberg, Martin Lambert, Vivien Kraft, Gregor Leicht, Christoph Mulert, Andreas J. Fallgatter, Thomas Ethofer, Anne Rau, Karolina Leopold, Andreas Bechdolf, Andreas Reif, Silke Matura, Felix Bermpohl, Jana Fiebig, Thomas Stamm, Christoph U. Correll, Georg Juckel, Vera Flasbeck, Philipp Ritter, Michael Bauer, Andrea Pfennig
Summary: Machine learning using structural magnetic resonance imaging can aid in early recognition of bipolar disorder risk and reduce disease burden.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Fabian Huth, Leonardo Tozzi, Michael Marxen, Philipp Riedel, Kyra Broeckel, Julia Martini, Christina Berndt, Cathrin Sauer, Christoph Vogelbacher, Andreas Jansen, Tilo Kircher, Irina Falkenberg, Florian Thomas-Odenthal, Martin Lambert, Vivien Kraft, Gregor Leicht, Christoph Mulert, Andreas J. Fallgatter, Thomas Ethofer, Anne Rau, Karolina Leopold, Andreas Bechdolf, Andreas Reif, Silke Matura, Silvia Biere, Felix Bermpohl, Jana Fiebig, Thomas Stamm, Christoph U. Correll, Georg Juckel, Vera Flasbeck, Philipp Ritter, Michael Bauer, Andrea Pfennig, Pavol Mikolas
Summary: The pathophysiology of bipolar disorder (BD) is unclear, but a valid biomarker is needed for early detection. This study used structural MRI to compare volumes of hippocampus, amygdala, and their subfields/nuclei in individuals at risk for BD. Although there were no volume differences between risk groups, machine learning could still predict the risk for BD based on certain criteria. This suggests that neural changes may have prognostic value in BD.
Review
Psychiatry
Sabine Arnold, Christoph U. U. Correll, Charlotte Jaite
Summary: Youth with eating disorders, especially those who are inpatient, have a high risk of suicidal ideation and suicide attempts. This study found that almost half of the patients with anorexia nervosa binge-purging type (AN-BP) and bulimia nervosa (BN) had lifetime suicidal ideation, and approximately 10% of AN-BP patients had attempted suicide. Treatment programs should address the specific clinical correlates of suicidality, such as low body weight, psychiatric comorbidities, history of childhood abuse, and non-suicidal self-injury.
BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION
(2023)
Article
Clinical Neurology
Martin Koster Rimvall, Ditte Vassard, Sabrina Mai Nielsen, Rasmus Trap Wolf, Kerstin Jessica Plessen, Niels Bilenberg, Per Hove Thomsen, Mikael Thastum, Simon-Peter Neumer, Louise Berg Puggaard, Mette Maria Agner Pedersen, Anne Katrine Pagsberg, Wendy K. Silverman, Christoph U. Correll, Robin Christensen, Pia Jeppesen
Summary: The study found that Mind My Mind (MMM) cognitive behavioral therapy is effective in treating common emotional and behavioral mental health problems in youth, but not all individuals respond satisfactorily to treatment. The analysis revealed that youths with any mental disorder at baseline, comorbidity, and longer duration of untreated mental health problems showed superior treatment benefits. This highlights the importance of community-based programs like MMM for youth with substantial mental health problems.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Peter J. Uhlhaas, Christopher G. Davey, Urvakhsh Meherwan Mehta, Jai Shah, John Torous, Nicholas B. Allen, Shelli Avenevoli, Tolulope Bella-Awusah, Andrew Chanen, Eric Y. H. Chen, Christoph U. Correll, Kim Q. Do, Helen L. Fisher, Sophia Frangou, Ian B. Hickie, Matcheri S. Keshavan, Kerstin Konrad, Francis S. Lee, Cindy H. Liu, Beatriz Luna, Patrick D. McGorry, Andreas Meyer-Lindenberg, Merete Nordentoft, Dost Oenguer, George C. Patton, Tomas Paus, Ulrich Reininghaus, Akira Sawa, Michael Schoenbaum, Gunter Schumann, Vinod H. Srihari, Ezra Susser, Swapna K. Verma, T. Wilson Woo, Lawrence H. Yang, Alison R. Yung, Stephen J. Wood
Summary: Most mental disorders have an onset between 12 and 25 years of age, emphasizing the importance of this period for understanding and addressing mental ill-health. This perspective highlights the interactions between risk and protective factors and brain development in the emergence of psychopathology in youth. It proposes the need for novel approaches to early diagnosis and interventions that reflect the evolving nature of psychopathology and promote knowledge exchange between science and practitioners. Overall, it advocates for a transformative early intervention paradigm to enhance mental health in young people and shift towards preventing severe mental disorders.
MOLECULAR PSYCHIATRY
(2023)
News Item
Clinical Neurology
Marco Solmi, Christoph U. Correll
Summary: Two recent studies analyze medication prescription, patient characteristics, and treatment effectiveness of people with schizophrenia using a French population-based disease registry. These studies also highlight the disparities in healthcare and outcomes for these individuals compared to the general population.
NATURE REVIEWS NEUROLOGY
(2023)
Review
Psychology, Clinical
Bettina Frank, Sabine Arnold, Charlotte Jaite, Christoph U. Correll
Summary: This study found that the use of antipsychotic medication in the treatment of anorexia nervosa in youth did not significantly improve weight restoration compared to those not treated with antipsychotics. The weight and treatment duration of the youth who received antipsychotic treatment were also worse compared to those who did not receive such treatment.
JOURNAL OF EATING DISORDERS
(2023)
Meeting Abstract
Clinical Neurology
John Edwards, Suresh Durgam, Susan G. Kozauer, Jason Huo, Robert E. Davis, Sharon Mates, Christoph U. Correll
Letter
Psychiatry
John M. Kane, Taishiro Kishimoto, Eric Achtyes, Jose Rubio, Christoph Correll
Article
Psychiatry
Christoph U. U. Correll, Carmela Benson, Bruno Emond, Charmi Patel, Marie-Helene Lafeuille, Dee Lin, Laura Morrison, Isabelle Ghelerter, Patrick Lefebvre, Panagiotis Mavros
Summary: This retrospective study evaluated the benefit of different long-acting injectable (LAI) initiation strategies based on timing of behavioral and clinical events among Medicaid beneficiaries with schizophrenia. The study found that initiating LAIs prior to nonadherence to oral antipsychotics (OAPs) or occurrence of schizophrenia-related inpatient/ER visits was associated with fewer all-cause inpatient days and ER visits. Therefore, the LAI initiation strategy plays an important role in improving clinical outcomes for patients with schizophrenia.
Article
Clinical Neurology
Robert Litman, Dieter Naber, Lourdes Anta, Javier Martinez, Yuriy Filts, Christoph U. Correll
Summary: This study aimed to investigate the impact of Risperidone ISM on social functioning and health-related quality of life in patients with schizophrenia. The results showed that Risperidone ISM significantly improved social functioning and HR-QoL, and the therapeutic effects were rapid and sustained.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)