Environmental chemicals as substrates, inhibitors or inducers of drug transporters: implication for toxicokinetics, toxicity and pharmacokinetics

Mathematical model of uptake and metabolism of arsenic(III) in human hepatocytes - Incorporation of cellular antioxidant response and threshold-dependent behavior

(2011) Spyros K Stamatelos et al.   BMC Systems Biology

Constitutive activation of nuclear factor-E2-related factor 2 induces biotransformation enzyme and transporter expression in livers of mice with hepatocyte-specific deletion of Kelch-like ECH-associated protein 1

(2011) Qiuqiong Cheng et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Transcriptomic and Quantitative Proteomic Analysis of Transporters and Drug Metabolizing Enzymes in Freshly Isolated Human Brain Microvessels

(2011) Ramzi Shawahna et al.   MOLECULAR PHARMACEUTICS

Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor

(2011) Marcin Ratajewski et al.   TOXICOLOGY LETTERS

Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression

(2010) Shuhua Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Multi Drug Resistance-1 (MDR1) Expression in Response to Chronic Diazinon Exposure: An In vitro Study on Caco-2 Cells

(2010) Peiman Habibollahi et al.   BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

Selenium-dependent and -independent transport of arsenic by the human multidrug resistance protein 2 (MRP2/ABCC2): implications for the mutual detoxification of arsenic and selenium

(2010) M. W. Carew et al.   CARCINOGENESIS

Activation of Nrf2 by Microcystin-LR Provides Advantages for Liver Cancer Cell Growth

(2010) Nanqin Gan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Transporters in the Brain Endothelial Barrier

(2010) M. Ueno et al.   CURRENT MEDICINAL CHEMISTRY

The Role of the Placenta in Fetal Exposure to Xenobiotics: Importance of Membrane Transporters and Human Models for Transfer Studies

(2010) C. Prouillac et al.   DRUG METABOLISM AND DISPOSITION

Investigation of Microcystin Congener–Dependent Uptake into Primary Murine Neurons

(2010) Daniel Feurstein et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Drug transport by breast cancer resistance protein

(2010) Maren Poguntke et al.   Expert Opinion on Drug Metabolism & Toxicology

ABC transporters and cytochromes P450 in the human central nervous system: influence on brain pharmacokinetics and contribution to neurodegenerative disorders

(2010) Fabien Dutheil et al.   Expert Opinion on Drug Metabolism & Toxicology

Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier

(2010) Xueqian Wang et al.   FASEB JOURNAL

Regulation of drug transporter mRNA expression by interferon-γ in primary human hepatocytes

(2010) Marc Le Vee et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Effects of perfluorooctane sulfonate (PFOS) exposure on markers of inflammation in female B6C3F1 mice

(2010) Meagan A.M. Mollenhauer et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING

Ivermectin Interacts With Human ABCG2

(2010) Márton Jani et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Xenobiotic-Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes Modulated by Toxcast Chemicals

(2010) Daniel M. Rotroff et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Expression of ABCG2 (BCRP) Is Regulated by Nrf2 in Cancer Cells That Confers Side Population and Chemoresistance Phenotype

(2010) Anju Singh et al.   MOLECULAR CANCER THERAPEUTICS

Constitutive Androstane Receptor-Mediated Up-Regulation of ATP-Driven Xenobiotic Efflux Transporters at the Blood-Brain Barrier

(2010) X. Wang et al.   MOLECULAR PHARMACOLOGY

Aryl Hydrocarbon Receptor Is a Transcriptional Activator of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)

(2010) K. P. Tan et al.   MOLECULAR PHARMACOLOGY

Coexistence of passive and carrier-mediated processes in drug transport

(2010) Kiyohiko Sugano et al.   NATURE REVIEWS DRUG DISCOVERY

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Metal Impurities in Food and Drugs

(2010) Darrell R. Abernethy et al.   PHARMACEUTICAL RESEARCH

Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

(2010) C. D. Klaassen et al.   PHARMACOLOGICAL REVIEWS

Characterization of Cellular Uptake of Perfluorooctanoate via Organic Anion-Transporting Polypeptide 1A2, Organic Anion Transporter 4, and Urate Transporter 1 for Their Potential Roles in Mediating Human Renal Reabsorption of Perfluorocarboxylates

(2010) Ching-Hui Yang et al.   TOXICOLOGICAL SCIENCES

Transport of N-acetyl-S-(1,2-dichlorovinyl)-l-cysteine, a metabolite of trichloroethylene, by mouse multidrug resistance associated protein 2 (Mrp2)

(2010) Kirill Tsirulnikov et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters

(2009) Guoxiang Shen et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalamin

(2009) R. Beedholm-Ebsen et al.   BLOOD

Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study

(2009) Vibeke Andersen et al.   BMC CANCER

The Pharmacogenomics of Membrane Transporters Project: Research at the Interface of Genomics and Transporter Pharmacology

(2009) D L Kroetz et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Liver Transporters in Hepatic Drug Disposition: An Update

(2009) Peng Li et al.   CURRENT DRUG METABOLISM

Functional Characterization of Mouse Organic Anion Transporting Peptide 1a4 in the Uptake and Efflux of Drugs Across the Blood-Brain Barrier

(2009) A. Ose et al.   DRUG METABOLISM AND DISPOSITION

Role of membrane transporters in the safety profile of drugs

(2009) Edmund Jon Deoon Lee et al.   Expert Opinion on Drug Metabolism & Toxicology

Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines

(2009) Olivier Fardel et al.   Expert Opinion on Drug Metabolism & Toxicology

In vitroevidence for the role of OATP and OCT uptake transporters in drug–drug interactions

(2009) Jürgen Kindla et al.   Expert Opinion on Drug Metabolism & Toxicology

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of major efflux transporters under inflammatory conditions at the blood-brain barrierin vitro

(2009) Magdalena von Wedel-Parlow et al.   JOURNAL OF NEUROCHEMISTRY

MDR1 variants and risk of Parkinson disease

(2009) Katja Zschiedrich et al.   JOURNAL OF NEUROLOGY

Interactions between ABC-transport proteins and the secondaryFusariummetabolites enniatin and beauvericin

(2009) Rita Dornetshuber et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Interplay of Transporters and Enzymes in Drug and Metabolite Processing

(2009) K. Sandy Pang et al.   MOLECULAR PHARMACEUTICS

Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy

(2009) Nadiya Bakhiya et al.   TOXICOLOGY

Low doses of ochratoxin A upregulate the protein expression of organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney cortex

(2009) Vilim Žlender et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Organic anion transporting polypeptide (Oatp) 1a1-mediated perfluorooctanoate transport and evidence for a renal reabsorption mechanism of Oatp1a1 in renal elimination of perfluorocarboxylates in rats

(2009) Ching-Hui Yang et al.   TOXICOLOGY LETTERS

Overview of the Proton-coupled MCT (SLC16A) Family of Transporters: Characterization, Function and Role in the Transport of the Drug of Abuse γ-Hydroxybutyric Acid

(2008) Marilyn E. Morris et al.   AAPS Journal

Roles of Organic Anion Transporters in the Renal Excretion of Perfluorooctanoic Acid

(2008) Hatsuki Nakagawa et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Coordinate regulation of human drug-metabolizing enzymes, and conjugate transporters by the Ah receptor, pregnane X receptor and constitutive androstane receptor

(2008) Christoph Köhle et al.   BIOCHEMICAL PHARMACOLOGY

Effect of Endotoxin on the Expression of Placental Drug Transporters and Glyburide Disposition in Pregnant Rats

(2008) V. Petrovic et al.   DRUG METABOLISM AND DISPOSITION

Regulation of Drug Transporter Expression in Human Hepatocytes Exposed to the Proinflammatory Cytokines Tumor Necrosis Factor-  or Interleukin-6

(2008) M. L. Vee et al.   DRUG METABOLISM AND DISPOSITION

Regulation of Drug-Metabolizing Enzymes and Transporters in Infection, Inflammation, and Cancer

(2008) E. T. Morgan et al.   DRUG METABOLISM AND DISPOSITION

Dioxin- and POP-contaminated sites—contemporary and future relevance and challenges

(2008) Roland Weber et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Mechanisms of renal anionic drug transport

(2008) Azza A.K. El-Sheikh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The role of hepatic transporters in drug elimination

(2008) Christoph Funk   Expert Opinion on Drug Metabolism & Toxicology

The pregnane X receptor: from bench to bedside

(2008) Xiaochao Ma et al.   Expert Opinion on Drug Metabolism & Toxicology

Intestinal efflux transporters and drug absorption

(2008) Teruo Murakami et al.   Expert Opinion on Drug Metabolism & Toxicology

Up-regulation and Cytoprotective Role of Epithelial Multidrug Resistance-associated Protein 1 in Inflammatory Bowel Disease

(2008) Hans Blokzijl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions of Organic Anion Transporters and Organic Cation Transporters With Mycotoxins

(2008) Kittipong Tachampa et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney

(2008) Zoulikha M Zaïr et al.   PHARMACOGENOMICS

A Possible Role of Multidrug Resistance–Associated Protein 2 (Mrp2) in Hepatic Excretion of PCB126, an Environmental Contaminant: PBPK/PD Modeling

(2008) Manupat Lohitnavy et al.   TOXICOLOGICAL SCIENCES

Nrf2- and PPARα-Mediated Regulation of Hepatic Mrp Transporters after Exposure to Perfluorooctanoic Acid and Perfluorodecanoic Acid

(2008) Jonathan M. Maher et al.   TOXICOLOGICAL SCIENCES

A Concentration Addition Model for the Activation of the Constitutive Androstane Receptor by Xenobiotic Mixtures

(2008) William S. Baldwin et al.   TOXICOLOGICAL SCIENCES

Characterization of Organic Anion Transporting Polypeptide 1b2-null Mice: Essential Role in Hepatic Uptake/Toxicity of Phalloidin and Microcystin-LR

(2008) Hong Lu et al.   TOXICOLOGICAL SCIENCES

Specific interactions of chloroacetanilide herbicides with human ABC transporter proteins

(2008) Berend Oosterhuis et al.   TOXICOLOGY

ABCG2/BCRP decreases the transfer of a food-born chemical carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in perfused term human placenta

(2008) Päivi Myllynen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

SLC28 genes and concentrative nucleoside transporter (CNT) proteins

(2008) M. Pastor-Anglada et al.   XENOBIOTICA

Physiology, structure, and regulation of the cloned organic anion transporters

(2008) C. Srimaroeng et al.   XENOBIOTICA

Organic cation transporters

(2008) G. Ciarimboli   XENOBIOTICA

Human equilibrative nucleoside transporter (ENT) family of nucleoside and nucleobase transporter proteins

(2008) J. D. Young et al.   XENOBIOTICA

Peptide transporters and their roles in physiological processes and drug disposition

(2008) I. Rubio-Aliaga et al.   XENOBIOTICA

Compound profiling for ABCC2 (MRP2) using a fluorescent microplate assay system

(2007) Frank Förster et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Hepatocyte growth factor increases uptake of estradiol 17β-d-glucuronide and Oatp1 protein level in rat hepatocytes

(2007) Tomomi Iwakiri et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of fumonisin B1 on the expression of cytokines and chemokines in human dendritic cells

(2007) H. Stockmann-Juvala et al.   FOOD AND CHEMICAL TOXICOLOGY

ABC multidrug transporters: structure, function and role in chemoresistance

(2007) Frances J Sharom   PHARMACOGENOMICS