Maximizing the outcome of early ADMET models: strategies to win the drug-hunting battles?
出版年份 2011 全文链接
标题
Maximizing the outcome of early ADMET models: strategies to win the drug-hunting battles?
作者
关键词
-
出版物
Expert Opinion on Drug Metabolism & Toxicology
Volume 7, Issue 4, Pages 381-386
出版商
Informa Healthcare
发表日期
2011-03-19
DOI
10.1517/17425255.2011.562199
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes
- (2010) Travis T. Wager et al. ACS Chemical Neuroscience
- Predictions of Metabolic Drug-Drug Interactions Using Physiologically Based Modelling
- (2010) Nathalie Perdaems et al. CLINICAL PHARMACOKINETICS
- Design and Application of Microfluidic Systems for In Vitro Pharmacokinetic Evaluation of Drug Candidates
- (2010) T. Maguire et al. CURRENT DRUG METABOLISM
- Evolving molecules using multi-objective optimization: applying to ADME/Tox
- (2010) Sean Ekins et al. DRUG DISCOVERY TODAY
- Sandwich-cultured hepatocytes: anin vitromodel to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity
- (2010) Brandon Swift* et al. DRUG METABOLISM REVIEWS
- Integration ofin silicoandin vitroplatforms for pharmacokinetic–pharmacodynamic modeling
- (2010) Jong Hwan Sung et al. Expert Opinion on Drug Metabolism & Toxicology
- Mitigating permeability-mediated risks in drug discovery
- (2010) Jianling Wang et al. Expert Opinion on Drug Metabolism & Toxicology
- Practical Anticipation of Human Efficacious Doses and Pharmacokinetics Using In Vitro and Preclinical In Vivo Data
- (2009) Tycho Heimbach et al. AAPS Journal
- Recent Advances in Physicochemical and ADMET Profiling in Drug Discovery
- (2009) Jianling Wang et al. CHEMISTRY & BIODIVERSITY
- High Throughput Screening of Physicochemical Properties and In Vitro ADME Profiling in Drug Discovery
- (2009) Hong Wan et al. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
- Comprehensive Assessment of ADMET Risks in Drug Discovery
- (2009) Jianling Wang CURRENT PHARMACEUTICAL DESIGN
- ADME Optimization and Toxicity Assessment in Early- and Late-Phase Drug Discovery
- (2009) Gary Caldwell et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Early integration of pharmacokinetic and dynamic reasoning is essential for optimal development of lead compounds: strategic considerations
- (2009) Johan Gabrielsson et al. DRUG DISCOVERY TODAY
- The Simcyp®Population-based ADME Simulator
- (2009) Masoud Jamei et al. Expert Opinion on Drug Metabolism & Toxicology
- In vitrosafety pharmacology profiling: what else beyond hERG?
- (2009) Jacques Hamon et al. Future Medicinal Chemistry
- Application of CYP3A4 in vitro data to predict clinical drug–drug interactions; predictions of compounds as objects of interaction
- (2008) Kuresh A. Youdim et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose
- (2008) R. Scott Obach et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Structure – ADME relationship: still a long way to go?
- (2008) Tingjun Hou et al. Expert Opinion on Drug Metabolism & Toxicology
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started