期刊
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
卷 7, 期 4, 页码 441-455出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/17425255.2011.557066
关键词
adenosine A(2A) receptor; istradefylline; Parkinson's disease; preladenant; vipadenant
资金
- Hungarian Agency for Research Fund Management and Research Exploitation [NAP-BIO-06-BAYBIOSZ]
- Medical Research Council [ETT 026-04]
- National Development Agency of Hungary [TaMOP-4.2.2.-08/1/2008-2002]
- European Commission [LSHM-CT-2007-037950]
- Hungarian Academy of Sciences
Areas covered: This review is based on a PubMed search covering the relationship of the adenosine receptors and PD. The role of the AA2AR is reviewed and the results of preclinical investigations of antagonists are assessed. A synopsis of current drug development is provided, with a special focus on the pharmacokinetics and relevant clinical trials. Expert opinion: The localization of the AA2AR in the central nervous system, the ultra structural localization and the molecular mechanism of its action reveal the potential importance of the AA2AR in movement disorders. The theoretical background and experimental data indicate that AA2AR antagonists may have a potential therapeutic effect in Parkinson's disease. More importantly, the putative neuroprotective effect needs further investigation.
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