Article
Pharmacology & Pharmacy
Naoki Katayama, Keiichi Odagiri, Akio Hakamata, Chiaki Kamiya, Shinya Uchida, Shimako Tanaka, Naoki Inui, Noriyuki Namiki, Koichiro Tatsumi, Hiroshi Watanabe
Summary: This study investigated the impact of clopidogrel on the pharmacokinetics of selexipag and its active metabolite in 14 healthy Japanese volunteers. The results showed that co-administration of clopidogrel with selexipag did not affect selexipag's pharmacokinetics, but significantly increased the AUC(0-infinity) of ACT-333679. Furthermore, even when selexipag was administered 1 day after discontinuation of clopidogrel, there was still an increase in the AUC(0-infinity) of ACT-333679, indicating a persistent inhibitory effect of clopidogrel on CYP2C8.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Meng Fu, Lin Luo, Sheng Feng, Hongda Lin, Zekun Lu, Fei Gu, Yang Fan, Bing Wu, Jianying Huang, Kai Shen
Summary: This study evaluated the effects of SHR0302 on the pharmacokinetics of cytochrome P450 (CYP) probe substrates. The results demonstrated that co-administration of SHR0302 did not have a clinically meaningful effect on the exposure of drugs metabolized by CYP3A4, CYP2C8, CYP2C9 and CYP2C19 in healthy subjects.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Yan Ding, Huida Guan, Yingxuan Yan, Yan Chen, Cheng Huang
Summary: This study aimed to investigate the drug-drug interaction (DDI) of Nomilin (Nom) and Atorvastatin (Atv) in vivo. The pharmacokinetic and pharmacodynamic studies revealed that Nom can impact the pharmacokinetic profile and pharmacodynamic effect of Atv, leading to a lesser reduction in lipid levels of mice treated with the combination of Nom and Atv. Furthermore, Nom can increase the activity and expression levels of hepatic microsomal CYP3A11.
Review
Chemistry, Medicinal
Subrata Deb, Anthony Allen Reeves, Robert Hopefl, Rebecca Bejusca
Summary: The global pandemic of COVID-19 has highlighted the importance of exploring treatment options like remdesivir, originally designed for Ebola, in combating the disease. However, limited information on the ADME, PK, and DDI of remdesivir underscores the need for further research to ensure effective treatment for patients.
Review
Pharmacology & Pharmacy
Aleksi Tornio, Anne M. Filppula, Janne T. Backman
Summary: Multimorbidity, polypharmacotherapy, and drug interactions are prevalent in the ageing population. Drug-drug interactions can have negative health impacts, requiring translational research approaches to fully characterize the mechanisms, clinical effects, and implications of CYP-mediated DDIs.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Annette Rudolph, Hendrike Dahmke, Hugo Kupferschmidt, Andrea Burden, Stefan Weiler
Summary: The coadministration of tizanidine and ciprofloxacin can lead to potentially severe adverse effects, especially in multimorbid patients. Despite the existing formal contraindication, the concomitant use of these two drugs is still observed in real-world clinical practice and should be avoided to prevent harmful outcomes.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Donald G. Lamprecht Jr, Joseph J. Saseen, Paul B. Shaw
Summary: Statins are important drugs for the prevention and treatment of atherosclerotic cardiovascular disease, but they can be affected by drug-drug interactions that increase the risk of statin-associated muscle symptoms. Recognition and avoidance of clinically significant statin DDIs is important for safe use, while concern over insignificant interactions may lead to underutilization or avoidance of statins in patients who would benefit from them.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Article
Nutrition & Dietetics
Chung-Ping Yu, Meng-Syuan Yang, Pei-Wen Hsu, Shiuan-Pey Lin, Yu-Chi Hou
Summary: The study revealed that the timing of cranberry ingestion can have divergent effects on the pharmacokinetics and pharmacodynamics of warfarin. Cranberry taken before warfarin decreased the exposure to warfarin in the body, while cranberry taken after warfarin enhanced the anticoagulation effect of warfarin.
Article
Anesthesiology
Catherine Chanfreau-Coffinier, Sony Tuteja, Leland E. Hull, Sally MacDonald, Olga Efimova, Jill Bates, Deepak Voora, David W. Oslin, Scott L. DuVall, Julie A. Lynch
Summary: The response to analgesic therapy is influenced by various factors, including genetics and drug interactions. This study aimed to evaluate the potential impact of pharmacogenetic (PGx) testing on the care of Veterans with noncancer pain who were prescribed opioids metabolized by the CYP2D6 gene. The results showed that a significant proportion of patients were at an elevated risk for undesirable responses to their opioid medication based on predicted phenotypes and drug-drug interactions. However, CYP2D6 testing was infrequently used, and the results were mainly utilized to optimize antidepressant treatments rather than pain medications. The findings suggest that utilizing PGx testing along with consideration of phenoconversion may enhance the precision medicine approach to pain management in Veterans.
Review
Pharmacology & Pharmacy
Camille Lenoir, Victoria Rollason, Jules A. Desmeules, Caroline F. Samer
Summary: Inflammation has a specific impact on CYP activities, depending on the nature and severity of the underlying inflammatory disease. The drug-disease interactions can significantly affect drug pharmacokinetic parameters and clinical management. Resolution of inflammation may lead to normalization of CYP activity, but further research is needed to clarify some equivocal results.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yiran Wang, Jihua Shi, Dapeng Dai, Jianping Cai, Shuanghu Wang, Yun Hong, Shan Zhou, Fangling Zhao, Quan Zhou, Peiwu Geng, Yunfang Zhou, Xue Xu, Qingfeng Luo
Summary: This study evaluated the drug-drug interactions between vonoprazan and eleven common cardiovascular drugs through in vitro and in vivo experiments. The results showed that amlodipine and nifedipine inhibit the metabolism of vonoprazan and amlodipine affects vonoprazan's metabolism in vivo. Molecular simulation suggested that the CYP2B6 enzyme may play a larger role in vonoprazan's metabolism. Therefore, caution should be exercised when prescribing vonoprazan with cardiovascular drugs, especially amlodipine.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jinhui Wang, Feifei Chen, Hui Jiang, Jia Xu, Deru Meng, Peiwu Geng, Dapeng Dai, Jingbo Hu, Yunfang Zhou, Quan Zhou, Shuanghu Wang
Summary: Poziotinib is an irreversible pan-HER tyrosine kinase inhibitor used for the treatment of various cancers. It interacts with CYP enzymes, particularly inhibiting CYP2B1 and CYP2C11 activity in rats. This suggests the potential for drug interactions with these enzymes and the need for caution in clinical settings.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Eleni Aklillu, Ephrem Engidawork
Summary: Despite the increasing trend of khat chewing with medications and the potential risk for the occurrence of clinically significant interactions, there is a lack of data in the literature demonstrating the magnitude of the risk. Available data clearly demonstrate that the consequence of drug-khat interaction is dependent on genotype, and genotyping could be used to improve clinical outcome and minimize adverse reactions.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xu Wang, Jingjing Fa, Yuanjin Zhang, Shengbo Huang, Jie Liu, Junqing Gao, Lina Xing, Zongjun Liu, Xin Wang
Summary: There is a potential interaction between Danshen tablet and rivaroxaban as the former inhibits the metabolism of the latter. This may be due to the strong inhibitory effects of Danshen tablet's components, particularly dihydrotanshinone I, on CYP enzymes. Therefore, drug monitoring and dosage adjustment are necessary when Danshen tablet and rivaroxaban are used simultaneously in clinical practice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Zhen-Wei Yu, Guo-Dong Lou, Le-Le Ge
Summary: This study developed a rapid and accurate method for screening CYP inducers in a traditional Chinese medicine, Shenmai injection, by combining a PXR reporter gene assay and LC-TOF-MS analysis. Ethanol extract showed stronger PXR activity than aqueous extract, with methyl ophiopogonanone B and ginsenoside F2 identified as CYP inducers. The identification method used in this study was found to be suitable and effective for screening CYP inducers in herbal preparations.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
