Article
Gastroenterology & Hepatology
Raquel Cameron, Marjorie M. Walker, Michael Jones, Guy D. Eslick, Simon Keely, Peter Pockney, Carolina C. Cosentino, Nicholas J. Talley
Summary: This study examined the changes of eosinophils and other immune cells in the mucosa of colonic diverticula through quantitative histology. The results showed a significant increase in eosinophil counts at the base and neck of the diverticula. These findings provide new clues for understanding the role of eosinophils and chronic inflammation in the pathophysiology of colonic diverticulosis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Medicine, General & Internal
Elisabetta Bretto, Ferdinando D'Amico, Walter Fiore, Antonio Tursi, Silvio Danese
Summary: Diverticular disease is a common gastrointestinal condition characterized by chronic nonspecific symptoms and potential complications. Recent research suggests that intestinal dysbiosis and chronic inflammation play important roles in disease progression. Probiotic strain LCDG has the potential to rebalance gut microbiota and reduce intestinal inflammation, making it a promising treatment option for patients with colonic DD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Antonio De Vincentis, Marco Santonico, Federica Del Chierico, Annamaria Altomare, Benedetta Marigliano, Alice Laudisio, Sofia Reddel, Simone Grasso, Alessandro Zompanti, Giorgio Pennazza, Lorenza Putignani, Michele Pier Luca Guarino, Michele Cicala, Raffaele Antonelli Incalzi
Summary: In patients with symptomatic uncomplicated diverticular disease (SUDD), rifaximin therapy can lead to significant changes in certain taxa of gut microbiota. While the electronic multisensorial system did not accurately reflect microbiota changes, it was able to predict clinical improvement in patients receiving rifaximin therapy effectively.
FRONTIERS IN MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Raquel Cameron, Marjorie M. Walker, Marcus Thuresson, Bjorn Roelstraete, Filip Skoldberg, Ola Olen, Nicholas J. Talley, Jonas F. Ludvigsson
Summary: This population-based cohort study in Sweden aimed to measure overall and cause-specific mortality in patients with colonic diverticular disease compared to matched reference individuals, using Cox regression models adjusted for comorbidity to estimate hazard ratios for all-cause mortality.
ANNALS OF EPIDEMIOLOGY
(2022)
Article
Infectious Diseases
Jeremy Grossman, Jun Fan, Felicia Allard, Jane Moon, Luis A. Marcos
Summary: This article reports a fatal case of S. stercoralis hyperinfection in an immigrant from rural Ecuador and emphasizes the importance of screening for this parasite in the appropriate clinical scenarios. Various diagnostic methods are introduced to make the diagnosis of S. stercoralis more accessible to practitioners.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
Xinquan Li, Qiang Wang, Xiafen Hu, Wanxin Liu
Summary: Probiotics play an important role in fighting infectious pathogens and reducing the risk of infectious diseases. However, more standardized clinical research is needed to establish their clinical application.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tiziano Balzano, Paola Leone, Gergana Ivaylova, M. Carmen Castro, Lestteriel Reyes, Chuse Ramon, Michele Malaguarnera, Marta Llansola, Vicente Felipo
Summary: In patients with liver cirrhosis, inflammation and immune cell infiltration play a role in triggering minimal hepatic encephalopathy. Rifaximin shows promise in improving neurological function by normalizing peripheral inflammation. This study in a rat model suggests that rifaximin may prevent neuroinflammation and motor incoordination in liver damage similar to steatohepatitis.
Article
Gastroenterology & Hepatology
Vladimir Ivashkin, Oleg Shifrin, Roman Maslennikov, Elena Poluektova, Alexander Korolev, Anna Kudryavtseva, George Krasnov, Nona Benuni, Giovanni Barbara
Summary: This study investigated the changes in the fecal microbiome of patients with symptomatic uncomplicated diverticular disease (SUDD) after repeated monthly treatment with rifaximin and found that rifaximin effectively decreased abdominal pain in these patients. The study also showed that rifaximin increased the abundance of beneficial microbial elements in the gut.
BMC GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Giovanni Marasco, Francesco Buttitta, Cesare Cremon, Maria Raffaella Barbaro, Vincenzo Stanghellini, Giovanni Barbara
Summary: This article summarizes the relationship between gut microbiota dysbiosis, the pathophysiology of diverticular disease (DD), and the development of symptoms. Research has found fecal microbial imbalance, especially an increase of pro-inflammatory and potentially pathogenetic bacteria, in patients with DD, particularly those with symptomatic disease. Furthermore, bacterial metabolic markers can reflect specific pathways of the disease and may be used to monitor treatment effects. Current treatments for DD can affect the structure of the gut microbiota and the composition of the metabolome.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Gastroenterology & Hepatology
Raquel Cameron, Kerith Duncanson, Emily C. Hoedt, Guy D. Eslick, Grace L. Burns, Cheenie Nieva, Simon Keely, Marjorie M. Walker, Nicholas J. Talley
Summary: This systematic review assessed the association between the microbiota and metabolome in diverticulosis, symptomatic uncomplicated diverticular disease (SUDD), and diverticulitis pathophysiology. The findings suggest that there is no convincing evidence of microbial dysbiosis in colonic diverticula to suggest that the microbiota contributes to the pathogenesis of diverticulosis, SUDD, or diverticular disease.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Psychiatry
Jong-Wook Lee, Hankil Lee, Hye-Young Kang
Summary: This study found a potential association between major depressive disorder (MDD) and antibiotic use, suggesting that patients with MDD are more vulnerable to infections and may require closer monitoring for infection prevention when managing their condition.
Review
Nutrition & Dietetics
Hsun-Chin Chao
Summary: The benefits of zinc in treating pediatric gastrointestinal diseases, particularly inflammatory bowel disease and celiac disease, are significant. Zinc supplementation has been shown to reduce the duration of diarrhea and may also be beneficial for peptic ulcer disease and gastroesophageal reflux disease. However, specific guidelines for zinc supplementation in children are lacking.
Article
Microbiology
Nhi Van, Yonatan N. Degefu, Pathricia A. Leus, Jonah Larkins-Ford, Jacob Klickstein, Florian P. Maurer, David Stone, Husain Poonawala, Cheleste M. Thorpe, Trever C. Smith, Bree B. Aldridge
Summary: New effective drug combinations have been found through the study of strain-specific drug interactions and the vast drug combination space, which can help improve the treatment of M. abscessus infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
R. De Bastiani, G. Sanna, L. Bertolusso, G. Casella, M. De Polo, M. Zamparella, C. Cottone, C. Tosetti, M. Mancuso, E. Pirrotta, L. Lanzarotto, L. Napoli, M. De Bastiani, G. Disclafani, P. Gambaro, R. Scoglio, A. Belvedere, S. Fasulo, M. D'Urso, E. Benedetto, E. Baldi, F. Marchesan, G. Abagnale, L. Turnava, E. Salome, F. Ingravalle, A. Tursi
Summary: This study investigated the efficacy of rifaximin treatment for symptomatic uncomplicated diverticular disease of the colon (SUDD) by General Practitioners (GPs) in a primary care setting. The results showed a significant reduction in symptoms after three months of treatment, with minimal adverse events recorded. Overall, rifaximin was found to be an effective treatment option for SUDD managed by GPs in real-life settings.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Annamaria Altomare, Manuele Gori, Silvia Cocca, Simone Carotti, Maria Francesconi, Mentore Ribolsi, Sara Emerenziani, Giuseppe Perrone, Sergio Morini, Michele Cicala, Michele P. L. Guarino
Summary: The study found that impaired intestinal motility in symptomatic uncomplicated diverticular disease (SUDD) patients may lead to increased intestinal mucosal permeability, which could be responsible for the onset of symptoms.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Letter
Gastroenterology & Hepatology
Francesco Santopaolo, Francesca Romana Ponziani, Andrea Contegiacomo, Maurizio Pompili, Antonio Gasbarrini, Alberto Larghi Gemelli
DIGESTIVE AND LIVER DISEASE
(2023)
Letter
Gastroenterology & Hepatology
Francesca Romana Ponziani, Francesco Santopaolo, Antonio Gasbarrini, Raimondo De Cristofaro, Maurizio Pompili
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Luigi Gatta, Olga P. Nyssen, Giulia Fiorini, Ilaria Maria Saracino, Matteo Pavoni, Marco Romano, Antonietta Gerarda Gravina, Lucia Granata, Rinaldo Pellicano, Antonio Gasbarrini, Alfredo Di Leo, Giuseppe Losurdo, Francesco Franceschi, Gerardo Nardone, Alba Rocco, Maria Pina Dore, Fabio Farinati, Matteo Ghisa, Massimo Bellini, John Holton, Ignasi Puig, Dino Vaira, Claudio Borghi, Francis Megraud, Colm O'Morain, Javier P. Gisbert
Summary: This study evaluated the effectiveness and safety of empirical first- and second-line treatments for Helicobacter pylori patients. Only quadruple therapies lasting at least 10 days achieved over 90% eradication rates, and high-dose PPI twice daily improved the effectiveness of some treatments.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Review
Oncology
Silvia Pecere, Cristina Ciuffini, Michele Francesco Chiappetta, Lucio Petruzziello, Luigi Giovanni Papparella, Cristiano Spada, Antonio Gasbarrini, Federico Barbaro
Summary: Colorectal cancer is a significant health issue, responsible for nearly 10% of cancer-related deaths. Screening is crucial for early detection of preneoplastic lesions or early-stage cancer. This review summarizes existing screening tools, their pros and cons, and highlights the potential game-changing technologies currently being investigated.
EXPERT REVIEW OF ANTICANCER THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Maria Elena Ainora, Lucia Cerrito, Antonio Liguori, Irene Mignini, Angela De Luca, Linda Galasso, Matteo Garcovich, Laura Riccardi, Francesca Ponziani, Francesco Santopaolo, Maurizio Pompili, Antonio Gasbarrini, Maria Assunta Zocco
Summary: A correct differentiation between hepatocellular carcinoma (HCC) and intracellular cholangiocarcinoma (ICC) is essential but challenging. Dynamic contrast-enhanced ultrasound (D-CEUS) and shear wave elastography (SWE) can provide valuable information for accurate diagnosis. A multiparametric ultrasound (MP-US) score based on D-CEUS and SWE parameters showed high accuracy in distinguishing ICC from HCC, potentially reducing the need for liver biopsy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Federica Borrelli de Andreis, Ivo Boskoski, Pietro Mascagni, Tommaso Schepis, Antonio Bianchi, Giovanni Schinzari, Brigida Eleonora Annicchiarico, Giuseppe Quero, Giampaolo Tortora, Sergio Alfieri, Antonio Gasbarrini, Guido Costamagna, Cristiano Spada, Fabia Attili
Summary: This retrospective study evaluated the feasibility and safety of endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) for unresectable pancreatic insulinomas. The study found that EUS-RFA was technically successful and achieved clinical remission in all patients, with no major complications observed. Complete radiologic response and symptom remission were assessed in all patients during follow-up.
Review
Nutrition & Dietetics
Antonio Pellegrino, Gaetano Coppola, Francesco Santopaolo, Antonio Gasbarrini, Francesca Romana Ponziani
Summary: The gut microbiota plays a critical role in host metabolism and immune response regulation, and its impairment is associated with various gastrointestinal and extraintestinal diseases. A. muciniphila is proven to be important in maintaining intestinal barrier integrity, modulating the host immune response, and improving metabolic pathways, making it a key factor in the pathogenesis of several human diseases. Further research is needed to explore its mechanisms of action and properties in order to develop a more integrated and personalized therapeutic approach based on the knowledge of gut microbiota.
Article
Immunology
Rossella Cianci, Laura Franza, Giulia Pignataro, Maria Grazia Massaro, Pierluigi Rio, Antonio Tota, Francesca Ocarino, Marta Sacco Fernandez, Francesco Franceschi, Antonio Gasbarrini, Giovanni Gambassi, Marcello Candelli
Summary: The impact of SARS-CoV-2 vaccination on the prognosis of infected patients was evaluated in this study. Results showed that vaccination with at least two doses reduced the need for ICU admission, and even one shot of the vaccine significantly reduced 30-day mortality. All-cause mortality related to SARS-CoV-2 infection has declined from the first wave to subsequent waves.
Article
Medicine, General & Internal
Matteo Garcovich, Mattia Paratore, Laura Riccardi, Maria Assunta Zocco, Maria Elena Ainora, Geltrude Mingrone, Antonio Gasbarrini, Maurizio Pompili
Summary: This study aimed to investigate the feasibility, correlation, and accuracy of a new point shear-wave elastography device (X+pSWE) in patients with chronic liver disease. The results showed a good correlation between X+pSWE and 2D-SWE with SSI, with X+pSWE values being slightly lower. X+pSWE had high AUROC values for staging fibrosis, and correctly identified most patients according to histologic classification.
Review
Medicine, General & Internal
Paolo Santini, Giorgio Esposto, Maria Elena Ainora, Andrea Lupascu, Antonio Gasbarrini, Maria Assunta Zocco, Roberto Pola
Summary: This review aims to find clinical evidence regarding the application of ultrasound elastography (UE) in the evaluation of deep-vein thrombosis (DVT) and its usefulness in differentiating thrombosis age. A literature search identified several studies that demonstrated an increase in thrombus stiffness with DVT age, despite significant differences in study design, thrombus age definitions, and patient characteristics.
Review
Biology
Valeria Maccauro, Carlo Airola, Francesco Santopaolo, Antonio Gasbarrini, Francesca Romana Ponziani, Maurizio Pompili
Summary: Liver cirrhosis is a chronic disease that often leads to complications such as variceal bleeding, hepatic encephalopathy, ascites, and jaundice, with increased mortality. Infections, particularly spontaneous bacterial peritonitis (SBP), are common in cirrhotic patients due to impaired immunity and altered intestinal microbiota. SBP is primarily caused by Gram-negative bacteria translocating through the defective intestinal barrier. The first-line treatment is antibiotic therapy, but it may worsen dysbiosis. Future therapies aim to selectively modulate the gut microbiota or reduce intestinal permeability.
Article
Medicine, General & Internal
Luca Miele, Marianxhela Dajko, Maria Chiara D. Savino, Nicola Capocchiano, Valentino Calvez, Antonio Liguori, Carlotta Masciocchi, Lorenzo Vetrone, Irene Mignini, Tommaso Schepis, Giuseppe Marrone, Marco Biolato, Alfredo Cesario, Stefano Patarnello, Andrea Damiani, Antonio Grieco, Vincenzo Valentini, Antonio Gasbarrini, Gemelli COVID Grp
Summary: This study aimed to develop and validate predictive mortality models using data from hospitalized COVID-19 patients. Increased FIB-4 index values were found to be associated with poor clinical outcomes. The study utilized artificial intelligence and big data processing to retrieve data and developed a multivariable logistic regression model. Among 4936 patients, 15.4% died.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Medicine, General & Internal
Marcello Candelli, Marta Sacco Fernandez, Giulia Pignataro, Giuseppe Merra, Gianluca Tullo, Alessandra Bronzino, Andrea Piccioni, Veronica Ojetti, Antonio Gasbarrini, Francesco Franceschi
Summary: Our study aimed to validate the ANCOC score and assess its ability to predict 60-day mortality risk regardless of vaccination status and viral variant. The results suggest that the ANCOC score is able to accurately predict 60-day mortality risk independent of viral variant and vaccination status.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Lorenzo Falsetti, Vincenzo Zaccone, Luca Santoro, Silvia Santini, Emanuele Guerrieri, Luca Giuliani, Giovanna Viticchi, Serena Cataldi, Antonio Gasbarrini, Francesco Landi, Angelo Santoliquido, Gianluca Moroncini
Summary: Patients with post-COVID-19 syndrome exhibit greater clinical complexity and a higher burden of comorbidities, as indicated by a higher CCI. Additionally, a higher CCI is associated with an increased risk of post-COVID-19 syndrome, with the presence of 1 or 4 or more CCI points associated with a 3-fold and 6-fold increased risk, respectively.
MEDICINA-LITHUANIA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Osman Oecal, Christoph J. Zech, Matthias P. Fabritius, Christian Loewe, Otto van Delden, Vincent Vandecaveye, Bernhard Gebauer, Thomas Berg, Christian Sengel, Irene Bargellini, Roberto Iezzi, Alberto Benito, Maciej Pech, Antonio Gasbarrini, Bruno Sangro, Peter Malfertheiner, Jens Ricke, Max Seidensticker
Summary: This study aims to identify clinical and imaging parameters associated with the progression of non-hypervascular hepatobiliary phase hypointense lesions during follow-up after treatment for hepatocellular carcinoma. The results suggest that T2 hyperintensity, diffusion restriction, cirrhosis, and higher ECOG-PS are independent risk factors for the progression of these lesions.
EUROPEAN RADIOLOGY
(2023)