Article
Behavioral Sciences
Margarita Papassava, Ekaterini Siomou, Iliada Nakou, Vasileios Cholevas, Anna Challa, Meropi Tzoufi
Summary: In children with epilepsy, long-term polytherapy may result in lower bone turnover rates, but after a year of vitamin D intake, bone biochemical markers improved.
EPILEPSY & BEHAVIOR
(2021)
Article
Veterinary Sciences
Tess K. Smith, Starr Cameron, Lauren A. Trepanier
Summary: Acute hepatopathy associated with oral administration of zonisamide in dogs is rare, with potentially life-threatening cases occurring in less than 1% of treated dogs. Some subclinical abnormalities in liver enzymes may be observed during chronic administration of zonisamide, but without clinical signs of liver disease.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Behavioral Sciences
Rafael Bernal Cobo, Lilliana Maria Giraldo Tapias, Tatiana Gomez Escobar, Luisa Fernanda Rueda Cardenas, Jose Fernando Zapata Berruecos, Elsa Maria Vasquez Trespalacios, Yessica Maria Giraldo Castrillon, Diego Fernando Rojas-Gualdron
Summary: This study analyzed the factors associated with the duration between seizure relapses in people with epilepsy. The results indicated that difficulties in the prescription filling process, history of multiple types of events, and neuropsychiatric comorbidity were correlated with a lower benefit from treatment to control seizure relapses.
EPILEPSY & BEHAVIOR
(2022)
Article
Behavioral Sciences
Xiaojing Shi, Yuanyuan Wang, Yaoyao Zhang, Changgeng Song, Yongli Jiang, Jingjing Zhao, Liang Xia, Lei Ma, Wen Jiang
Summary: This study investigated the management of pregnant women with epilepsy treated with multiple antiepileptic drugs. The results showed that certain combinations of drugs were associated with increased risks of adverse pregnancy outcomes and congenital malformations. Planned pregnancy was found to reduce the teratogenic effects of antiepileptic drugs. The combination of lamotrigine and levetiracetam seemed to be the most desirable option.
EPILEPSY & BEHAVIOR
(2022)
Article
Neurosciences
Xiaotong Yin, Yan Liu, Yang Guo, Limei Zhao, Guofei Li, Xiaoping Tan
Summary: The study found significant pharmacokinetic changes in newer antiepileptic drugs in women with epilepsy during pregnancy, highlighting the importance of therapeutic drug monitoring. It is recommended to monitor drug levels at least once per trimester and more frequently for women with poorly controlled seizures before pregnancy. Well-controlled seizures nine months before pregnancy can lower the risk of seizures during pregnancy, emphasizing the importance of pre-pregnancy counseling and seizure management.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Neurosciences
Valentina Franco, Meir Bialer, Emilio Perucca
Summary: CBD has shown therapeutic potential in seizure disorders, with progress made in understanding its mechanisms of action and clinical properties. A pharmaceutical-grade formulation of purified CBD has been approved for treatment in certain seizure syndromes, but interactions with other medications, such as clobazam, remain a complex issue. Despite advances, there are still significant gaps in knowledge regarding CBD's antiseizure activity.
Review
Pharmacology & Pharmacy
Barbara Miziak, Stanislaw J. Czuczwar, Ryszard Pluta
Summary: Patients with epilepsy may require antidepressant treatment due to the high prevalence of depression in this population. There may be pharmacodynamic and pharmacokinetic interactions between antiepileptic and antidepressant drugs. Animal data suggest that chronic administration of antidepressants can either enhance or reduce the anticonvulsant activity of certain antiepileptic drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Krzysztof Lukawski, Stanislaw J. Czuczwar
Summary: Approximately 70% of epilepsy patients can be successfully treated with antiepileptic drugs, but drug-resistant epilepsy is associated with poor quality of life and increased morbidity and mortality. Various hypotheses have been proposed to explain pharmacoresistance, and the search for newer AEDs or non-AEDs may provide efficacious drugs. Combinations of AEDs exerting synergy in preclinical and clinical studies could be important in managing drug-resistant epilepsy.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Article
Clinical Neurology
Julia H. van Tuijl, Elisabeth P. M. van Raak, Robert J. van Oostenbrugge, Albert P. Aldenkamp, Rob P. W. Rouhl
Summary: The study investigated the preventive effect of diazepam on seizures in acute stroke patients and found that a 3-day treatment with diazepam after acute cortical anterior circulation stroke can significantly reduce the occurrence of seizures.
CEREBROVASCULAR DISEASES
(2021)
Review
Clinical Neurology
Roberta Roberti, Carmen De Caro, Luigi Francesco Iannone, Gaetano Zaccara, Simona Lattanzi, Emilio Russo
Summary: Cenobamate is a promising antiseizure medication for focal onset seizures in adults, with a unique mechanism of action and pharmacokinetic profile. Further clinical studies are needed to fully understand its clinical characteristics and potential interactions with other drugs.
Article
Behavioral Sciences
Andrew G. Herzog, Hannah B. Mandle, Devon B. MacEachern
Summary: This study evaluated the seizure safety of hormonal contraception in women with epilepsy, finding that transitioning from non-hormonal contraception to hormonal contraception increased the risk of increased seizure frequency, with oral contraceptive pills posing a higher risk. The study suggests further research to assess the risk of increased seizures with hormonal contraception, particularly oral contraceptive pills.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Sandip Patel, Reid Grinspoon, Bradley Fleming, Lauren A. Skirvin, Christina Wade, Emma Wolper, Patricia L. Bruno, Elizabeth A. Thiele
Summary: CBD has been shown to maintain its efficacy in controlling seizures over a treatment period of up to 60 months, especially effective in controlling seizures in the setting of tuberous sclerosis complex and reducing epileptic spasms and absence seizures. CBD also remains effective over a broad dose range, with most subjects reducing the dose of at least one concomitant AED compared to baseline.
Article
Medicine, General & Internal
Rod W. Hunt, Helen G. Liley, Deepika Wagh, Rachel Schembri, Katherine J. Lee, Andrew D. Shearman, Samantha Francis-Pester, Koert DeWaal, Jeanie Y. L. Cheong, Monika Olischar, Nadia Badawi, Flora Y. Wong, David A. Osborn, Victor Samuel Rajadurai, Peter A. Dargaville, Bevan Headley, Ian Wright, Paul B. Colditz
Summary: This randomized clinical trial aimed to determine whether active management of electrographic and clinical seizures in encephalopathic term or near-term neonates improved survival free of severe disability at 2 years compared with only treating clinically detected seizures. The study found that treating electrographic and clinical seizures with currently used anticonvulsants did not significantly reduce the rate of death or disability at 2 years in a heterogeneous group of neonates with seizures. Additionally, there was evidence that cognitive outcomes were worse in the group where both types of seizures were actively managed.
Article
Clinical Neurology
Levente Hadady, Peter Klivenyi, Emilio Perucca, Stefan Rampp, Daniel Fabo, Csaba Bereczki, Guido Rubboli, Ali A. Asadi-Pooya, Michael R. Sperling, Sandor Beniczky
Summary: The study validated that the use of the algorithm recommending ASMs based on individual characteristics is associated with better outcomes compared to using less desirable ASMs, including higher retention rates, higher seizure freedom rates, and fewer discontinuations due to adverse effects. The freely available decision support system proved to be beneficial for healthcare professionals in prescribing medication for individuals with epilepsy.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Pavel Klein, Sami Aboumatar, Christian Brandt, Fang Dong, Gregory L. Krauss, Sarah Mizne, Juan Carlos Sanchez-Alvarez, Bernhard J. Steinhoff, Vicente Villanueva
Summary: This study evaluated the long-term efficacy and safety of adjunctive cenobamate in the treatment of uncontrolled focal seizures. The results showed that cenobamate reduced seizure frequency and had a high retention rate over a 48-month period. No new safety concerns were identified. These findings highlight the potential clinical benefits of cenobamate in long-term management of patients with uncontrolled focal seizures.
Editorial Material
Clinical Neurology
Sanjeev V. Kothare, Edwin Trevathan
Article
Clinical Neurology
Anne M. Morse, Kristin Kelly-Pieper, Sanjeev V. Kothare
PEDIATRIC NEUROLOGY
(2019)
Editorial Material
Clinical Neurology
Margarita Oks, Sanjeev V. Kothare
JOURNAL OF CLINICAL SLEEP MEDICINE
(2019)
Editorial Material
Clinical Neurology
Sanjeev V. Kothare, Suresh Kotagal
Editorial Material
Clinical Neurology
Anne Marie Morse, Sanjeev V. Kothare
JOURNAL OF CLINICAL SLEEP MEDICINE
(2019)
Review
Pediatrics
Stephanie Enner, Samiya Ahmad, Anne M. Morse, Sanjeev Kothare
CURRENT OPINION IN PEDIATRICS
(2020)
Article
Clinical Neurology
Yash D. Shah, Virginia Stringel, Ivan Pavkovic, Sanjeev V. Kothare
JOURNAL OF CLINICAL SLEEP MEDICINE
(2020)
Article
Neurosciences
Emily Cowan, Anli Liu, Simon Henin, Sanjeev Kothare, Orrin Devinsky, Lila Davachi
JOURNAL OF NEUROSCIENCE
(2020)
Review
Clinical Neurology
Ivan M. Pavkovic, Sanjeev Kothare
PEDIATRIC NEUROLOGY
(2020)
Editorial Material
Clinical Neurology
Sanjeev V. Kothare, Kristin Kelly-Pieper
JOURNAL OF CLINICAL SLEEP MEDICINE
(2020)
Review
Pediatrics
Stephanie Enner, Ivan Pavkovic, Sanjeev V. Kothare
Summary: Despite many years of study, sudden unexplained death is still a diagnosis of exclusion. Failure in the complex interplay between peripheral sensors and central cardiorespiratory regulation may result in sudden death. Recent studies emphasize the importance of diagnostic testing in identifying high-risk patients and suggest common pathways in sudden unexplained death in children.
CURRENT OPINION IN PEDIATRICS
(2021)
Article
Neurosciences
Danielle Brigham, Yash Shah, Kanwaljit Singh, Ivan Pavkovic, Shefali Karkare, Sanjeev Kothare
CLINICAL NEUROPHYSIOLOGY PRACTICE
(2020)
Meeting Abstract
Clinical Neurology
Nina Kim, Sanjeev Kothare, Harold Weinberg
Article
Genetics & Heredity
Wen-Hann Tan, Lynne M. Bird, Anjali Sadhwani, Rene L. Barbieri-Welge, Steven A. Skinner, Lucia T. Horowitz, Carlos A. Bacino, Lisa M. Noll, Cary Fu, Rachel J. Hundley, Logan K. Wink, Craig A. Erickson, Gregory N. Barnes, Anne Slavotinek, Rita Jeremy, Alexander Rotenberg, Sanjeev V. Kothare, Heather E. Olson, Annapurna Poduri, Mark P. Nespeca, Hillary C. Chu, Jennifer M. Willen, Kevin F. Haas, Edwin J. Weeber, Paul A. Rufo
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2018)
Article
Behavioral Sciences
Simonne Cohen, Ben D. Fulcher, Shantha M. W. Rajaratnam, Russell Conduit, Jason P. Sullivan, Melissa A. St Hilaire, Andrew J. K. Phillips, Tobias Loddenkemper, Sanjeev V. Kothare, Kelly McConnell, Paula Braga-Kenyon, William Ahearn, Andrew Shlesinger, Jacqueline Potter, Frank Bird, Kim M. Cornish, Steven W. Lockley