期刊
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
卷 4, 期 5, 页码 655-664出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/17425255.4.5.655
关键词
dopamine agonist; restless legs syndrome; ropinirole
Restless legs syndrome (RLS) is a chronic neurological disorder associated with sleep disturbance. Ropinirole, a non-ergot dopamine agonist, has been widely studied for the treatment of mode rate-to-severe primary RLS in a comprehensive clinical development program. In these studies, ropinirole was effective in significantly improving the symptoms of RLS, compared with placebo, in patients with moderate-to-severe primary RLS. These improvements are supported by data from individual studies, as well as by pooled analyses. Significant improvements in RLS symptoms were observed within 2 nights of treatment. Ropinirole also produced significant benefits on objective measures of RLS motor symptoms, such as periodic leg movements; and on subjective measures of sleep, ropinirole was generally well tolerated. A newly developed extended-re lease formulation of ropinirole may benefit patients who warrant an extended duration of therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据