期刊
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
卷 4, 期 9, 页码 1181-1186出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/17425255.4.9.1181
关键词
cytochromes P450; drug metabolism; enzyme structures; molecular modelling
The overall predictive ability of molecular modelling, as applied to the cytochrome P450 (CYP) system, is analysed in the light of current developments in a variety of techniques, including X-ray crystallography, molecular biology, enzyme kinetics, molecular mechanics and dynamics, in relation to its relevance to drug metabolism in humans. This review demonstrates that it is possible to generate realistic models for the major human CYPs, which metabolise xenobiotics that compare favourably with crystal structures, and thus may be used to derive substrate binding energies that agree closely with experimental Km values obtained from enzyme kinetics.
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