Article
Pharmacology & Pharmacy
Joseph J. Bivona, Madeleine M. Mank, Renee D. Stapleton, D. Clark Files, Michael J. Toth, Matthew E. Poynter
Summary: Skeletal muscle is an important contributor to local and systemic cytokine abundance during inflammatory events. The study reveals the critical involvement of muscle fibers in the early systemic inflammatory cytokine response to endotoxin, showing the direct contribution of myofibers to systemic cytokine production.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiangqin He, Kunzhe Dong, Jian Shen, Guoqing Hu, Jinhua Liu, Xiuhua Kang, Liang Wang, Reem T. Atawia, Islam Osman, Robert W. Caldwell, Meixiang Xiang, Wei Zhang, Zeqi Zheng, Liwu Li, David J. R. Fulton, Keyu Deng, Hongbo Xin, Jiliang Zhou
Summary: The study demonstrates the critical role of HMGXB4 in exacerbating endotoxemia by regulating the expression of inflammatory genes and inducing excessive NO production. Targeting HMGXB4 may serve as an effective therapeutic strategy for the treatment of sepsis as it can reduce pulmonary injury and mortality induced by LPS. Additionally, HMGXB4 also promotes inflammation by regulating the expression of ICAM1 in endothelial cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Hisatake Matsumoto, Brendon P. Scicluna, Kin Ki Jim, Fahimeh Falahi, Wanhai Qin, Berke Gurkan, Erik Malmstrom, Mariska T. Meijer, Joe M. Butler, Hina N. Khan, Tsuyoshi Takagi, Shunsuke Ishii, Marcus J. Schultz, Diederik van de Beek, Alex F. de Vos, Cornelis van 't Veer, Tom van der Poll
Summary: The study indicates that HIVEP1 acts as a negative regulator of NF-κB in monocytes, inhibiting the proinflammatory response induced by bacterial agonists. Dysregulation of HIVEP1 leads to significant changes in the monocyte transcriptome and modulation of NF-κB responsive genes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Health Care Sciences & Services
Roman Zazula, Michal Moravec, Frantisek Pehal, Tomas Nejtek, Marek Protus, Martin Muller
Summary: Myristic acid has been identified as a metabolite with high diagnostic sensitivity and specificity in patients with bacteraemia, sepsis, and SIRS. Its levels are significantly associated with severe trauma outcomes and inflammatory responses, making it a potential candidate marker for severe inflammation and sepsis. Patients with infection tended to have higher levels of myristic acid, especially within the first 24 hours of diagnosis.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell Biology
Theodomir Dusabimana, Jihyun Je, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park
Summary: This study revealed the crucial role of GOLPH3 in the development and progression of acute liver and kidney injury induced by endotoxemia. Upregulation of GOLPH3 was associated with high morbidity and mortality. Knockdown of GOLPH3 alleviated cellular stress response and inflammatory reaction, leading to the recovery of Golgi morphology and function. These findings suggest GOLPH3 as a potential therapeutic target for endotoxemia-induced tissue injury.
CELL DEATH & DISEASE
(2023)
Article
Critical Care Medicine
Anoop D. Shah, Niall S. MacCallum, Steve Harris, David A. Brealey, Edward Palmer, James Hetherington, Sinan Shi, David Perez-Suarez, Ari Ercole, Peter J. Watkinson, Andrew Jones, Simon Ashworth, Richard Beale, Stephen J. Brett, Mervyn Singer
Summary: The study successfully applied the Sepsis-3 criteria to electronic health records to describe the characteristics of critical care patients with sepsis. This may facilitate sepsis research on a larger scale using electronic health record data without relying on human coding.
CRITICAL CARE MEDICINE
(2021)
Article
Microbiology
Meiqi Zhao, Jiajia Ma, Huiru Liu, Ying Luo, Huiting Deng, Dandan Wang, Fengmei Wang, Peng Zhang
Summary: The gut microbiota plays a crucial role in the development of sepsis, with different enterotypes leading to varying levels of systemic inflammation. The amoxicillin-associated enterotype is characterized by an abundance of opportunistic pathogens, resulting in the most severe inflammation and liver injury in septic mice. These findings highlight the importance of modulating the gut microbiota to prevent or reduce the serious consequences of sepsis, particularly in gut-derived sepsis.
Article
Emergency Medicine
Joseph D. Lykins, Hani I. Kuttab, Erron M. Rourke, Michelle D. Hughes, Eric P. Keast, Jason A. Kopec, Brooke L. Ward, Natasha N. Pettit, Michael A. Ward
Summary: Factors associated with delayed administration of the second dose of antibiotics include ED boarding, antibiotics requiring more frequent dosing, receiving 30 mL/kg of fluids within three hours, and renal failure. Delays in second-dose administration were not found to be associated with increased mortality or other outcomes.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Critical Care Medicine
Laura Piccolo Serafim, Douglas A. Simonetto, Alexandra L. Anderson, Dae Hee Choi, Timothy J. Weister, Andrew C. Hanson, Patrick S. Kamath, Ognjen Gajic, Alice Gallo de Moraes
Summary: The study found that the use of systemic steroids in patients with cirrhosis and septic shock did not significantly affect mortality, length of ICU admission, or length of hospital stay, and also did not increase adverse effects. The prevalence of steroid use was higher in cirrhotic patients with higher vasopressor requirements.
Article
Multidisciplinary Sciences
Ismael Luna-Reyes, Erendira G. Perez-Hernandez, Blanca Delgado-Coello, Miguel Angel Avila-Rodriguez, Jaime Mas-Oliva
Summary: Peptide VSAK shows significant protective effects against the detrimental impact of lipopolysaccharides and systemic inflammatory response syndrome (SIRS), suggesting its potential as a candidate for developing new therapeutic approaches.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Fatemehalsadat Tabatabaeifar, Elham Isaei, Davood Kalantar-Neyestanaki, Jose Ruben Morones-Ramirez
Summary: With the spread of multi-drug-resistant bacteria and the lack of effective antibiotics to treat them, developing new therapeutic methods and strategies is crucial. This study evaluated the antibacterial and antibiofilm activity of different formulations containing ibuprofen, acetylsalicylic acid, and dexamethasone sodium phosphate in combination with various antibiotics on clinical isolates of Staphylococcus aureus and Pseudomonas aeruginosa, as well as their impact on biofilm-related gene expression.
Review
Medicine, General & Internal
Adriana Marques, Carla Torre, Rui Pinto, Bruno Sepodes, Joao Rocha
Summary: Sepsis is a life-threatening condition caused by a dysregulated host response to infection, affecting over 25 million people annually. Septic shock, a severe subset of sepsis, is characterized by persistent low blood pressure, with hospital mortality rates exceeding 40%. Despite advances in early sepsis mortality, long-term complications such as secondary infection remain a significant cause of death, and there are currently no sepsis-specific therapies. Immunostimulatory therapy, including cytokines, growth factors, immune checkpoint inhibitors, and cellular therapies, holds promise in addressing this unmet medical need.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Erik Malmstrom, Hina N. Khan, Cornelis van 't Veer, Melissa Stunnenberg, Mariska T. Meijer, Hisatake Matsumoto, Natasja A. Otto, Teunis B. H. Geijtenbeek, Alex F. de Vos, Tom van der Poll, Brendon P. Scicluna
Summary: JHDM1D-AS1 is an upregulated long non-coding RNA in monocytes obtained from sepsis patients. It can be induced by Toll-like receptor ligands and regulate the inflammatory response of monocytes. Overexpression of JHDM1D-AS1 can attenuate the inflammatory response.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Critical Care Medicine
Yunjoo Im, Danbee Kang, Ryoung-Eun Ko, Yeon Joo Lee, Sung Yoon Lim, Sunghoon Park, Soo Jin Na, Chi Ryang Chung, Mi Hyeon Park, Dong Kyu Oh, Chae-Man Lim, Gee Young Suh
Summary: This study analyzed the relationship between time-to-antibiotics and in-hospital mortality in patients with sepsis. The results showed that timely administration of antibiotics improved outcomes in patients with septic shock, but the association between early antibiotic administration and outcome was not as clear in patients with sepsis without shock.
Article
Medical Laboratory Technology
Michael R. Miller, Stephen R. Koch, Hyehun Choi, Fred S. Lamb, Ryan J. Stark
Summary: This study found that ASK1 expression increased in sepsis and after LPS challenge, with ASK1 inhibitors reducing cytokine production but not affecting permeability. Physical interaction between eNOS and ASK1 was observed, and ASK1 inhibition mainly impaired JNK activation, affecting cytokine production.
TRANSLATIONAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Maha Mohamed Sabry, Mona Mohamed Ahmed, Omnia Mohamed Abdel Maksoud, Laila Rashed, Mary Attia Morcos, Amal Abo El-Maaty, Amr Maher Galal, Nivin Sharawy
Summary: The study found that the treatments of resveratrol, L-carnitine, and apelin can alter mitochondrial related protein levels, decrease intra-renal RAS parameters, increase ATP level, and upregulate Na+-K(+)ATPase gene expression in renal tissue, providing new insights into the role of mitochondrial quality control and the beneficial effects of antioxidants on acute kidney injury.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Medicine, General & Internal
Saki Sultana, Geraint Berger, Christian Lehmann
Summary: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic condition with unknown etiology and limited treatment options. Modulating the endogenous cannabinoid system (ECS) has shown benefits in alleviating pain and inflammation associated with IC/BPS.
Article
Biochemistry & Molecular Biology
Christian Lehmann, Nazli Alizadeh-Tabrizi, Stefan Hall, Sufyan Faridi, Irene Euodia, Bruce Holbein, Juan Zhou, Valerie Chappe
Summary: The iron chelator, DIBI, exhibits beneficial anti-inflammatory effects in experimental acute lung injury by reducing histopathological damage, inflammatory mediator levels, and NF-kappa B p65 activation.
Article
Physiology
Nivin Sharawy, Ahmad Abdel-Aliem Imam, Basma Emad Aboulhoda, Mohamed Mansour Khalifa, George N. B. Morcos, Waleed Ahmed Abd Algaleel, Passant E. E. Moustafa, Marwan A. A. Abdelbaset, Tarek Shoukry
Summary: Encephalopathy is a common and lethal consequence of sepsis. This study found that sepsis leads to iron excess and inflammation in the brain, which can explain the neurological dysfunction observed during sepsis.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Wujood Khayat, Christian Lehmann
Summary: Abnormal blood coagulation is a common manifestation of many pathological conditions, and cannabinoids may modulate blood coagulation through the endogenous cannabinoid system. However, there is controversial evidence regarding the effects of cannabinoids on blood coagulation. Understanding the interaction between the coagulation system and the endogenous cannabinoid system is crucial for developing therapeutics for coagulopathies.
Review
Biology
Sufia Islam, Nazia Hoque, Nishat Nasrin, Mehnaz Hossain, Farhana Rizwan, Kushal Biswas, Muhammad Asaduzzaman, Sabera Rahman, David W. Hoskin, Saki Sultana, Christian Lehmann
Summary: Breast cancer is a common cause of death among women worldwide. Current therapeutic approaches for breast cancer have limitations, leading to the search for new treatment options. This review focuses on the use of iron chelators to decrease iron levels and inhibit breast tumor growth.
Review
Biology
Cassidy Scott, Daniel Neira Agonh, Christian Lehmann
Summary: Antibiotic resistance poses a significant threat to healthcare and human health. Phytoannabinoids have antimicrobial activity and can overcome antibiotic resistance, making further research on their potential therapeutic use important.
Article
Medicine, Research & Experimental
Sarah Ali Abdelhameed Gouda, Basma Emad Aboulhoda, Omaima Mohammed Abdelwahed, Hend Abdallah, Laila Rashed, Rania Elsayed Hussein, Nivin Sharawy
Summary: The present study found that low-intensity pulsed ultrasound (LIPUS) can inhibit the pro-inflammatory response of M1 macrophages and promote the anti-inflammatory response of M2 macrophages in acute kidney injury. It also reverses gentamicin-induced renal damage by inhibiting necroptosis and reducing the expression of heat shock protein-70.
Article
Orthopedics
Michael D. Liette, Peter A. Crisologo, Suhail Masadeh, Sung H. Yang, Christian B. Bergmann, Charles C. Caldwell, Jordan A. Henning
Summary: This study aimed to prospectively enroll patients with lower extremity infections in the emergency department, stratify their risk using the WIfI classification system, and record their outcomes. The results showed that the WIfI classification system was effective in predicting patient outcomes during hospitalization and one-year follow-up. The study also found significant differences in healing rates, surgical dehiscence, and one-year mortality with increasing WIfI stage. Therefore, the early application of the WIfI classification system can help assess risk, guide early intervention, and improve outcomes in severe multimorbid patients.
JOURNAL OF FOOT & ANKLE SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Kayle Dickson, Cassidy Scott, Hannah White, Juan Zhou, Melanie Kelly, Christian Lehmann
Summary: Beta-caryophyllene has been shown to have anti-inflammatory effects and potential antibacterial properties. This study investigated the effects of beta-caryophyllene in a murine model of urinary tract infection (UTI) and found that it significantly reduced bacterial burden, improved behavioral responses, and reduced inflammation in the bladder. This suggests that beta-caryophyllene could be a useful adjunct therapy for UTI management.
Review
Urology & Nephrology
Juan Zhou, Cassidy Scott, Ziba Rovei Miab, Christian Lehmann
Summary: Ketamine is a dissociative anesthetic commonly used for anesthesia. Chronic abuse of ketamine can lead to urinary system complications, such as ketamine-induced cystitis. Treatment involves cessation of ketamine use and individualized plans based on symptoms and disease progression.
NEUROUROLOGY AND URODYNAMICS
(2023)
Editorial Material
Physiology
Hania Ammar, Nivin Sharawy, Christian Lehmann
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Bruce E. Holbein, Christian Lehmann
Summary: Iron is essential for various biological processes but can be toxic in excess. Dysregulation of iron metabolism has been linked to a range of diseases, including infections, cancer, and neurological disorders. Current therapies for iron dysregulation have limitations, but new iron chelators and hepcidin agonists show promise. Harnessing iron-driven reactive oxygen species generation and ferroptosis may offer selective cancer cell destruction. This review discusses iron requirements, regulation, and dysregulation in diseases, as well as potential new therapies.
Review
Biology
Xiyang Zhang, Juan Zhou, Bruce E. Holbein, Christian Lehmann
Summary: Acute lung injury (ALI) has been a challenging issue in healthcare systems for a long time, and effective prevention and treatment strategies are still lacking. Iron dysregulation is a common characteristic in many subtypes of ALI, playing a dual role in immune response and host cell damage. Iron chelation offers a novel therapeutic approach for alleviating lung injury and improving the survival of ALI patients. This article provides an overview of iron homeostasis, the role of iron in ALI development, and potential therapeutic targets.
Review
Biochemistry & Molecular Biology
Cassidy Scott, Daniel Neira Agonh, Hannah White, Saki Sultana, Christian Lehmann
Summary: Intravital microscopy (IVM) is a powerful imaging tool that captures real-time biological processes, allowing observation of complex cellular interactions in vivo. It has become essential in characterizing immune responses through visualization of changes in leukocyte-endothelial interactions and microcirculation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)