3Din vitrotissue models and their potential for drug screening

Glioma Cell Migration on Three-dimensional Nanofiber Scaffolds Is Regulated by Substrate Topography and Abolished by Inhibition of STAT3 Signaling

(2015) Paula A. Agudelo-Garcia et al.   NEOPLASIA

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

AlgiMatrix™ Based 3D Cell Culture System as an In-Vitro Tumor Model for Anticancer Studies

(2013) Chandraiah Godugu et al.   PLoS One

Bioengineered 3D Human Kidney Tissue, a Platform for the Determination of Nephrotoxicity

(2013) Teresa M. DesRochers et al.   PLoS One

Spheroid culture as a tool for creating 3D complex tissues

(2013) Eelco Fennema et al.   TRENDS IN BIOTECHNOLOGY

In vitro fabrication of functional three-dimensional tissues with perfusable blood vessels

(2013) Hidekazu Sekine et al.   Nature Communications

Rotator Cuff Regeneration Using a Bioabsorbable Material With Bone Marrow–Derived Mesenchymal Stem Cells in a Rabbit Model

(2012) Shin Yokoya et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

The XTT Cell Proliferation Assay Applied to Cell Layers Embedded in Three-Dimensional Matrix

(2012) Lynn Huyck et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

High-throughput cellular screening of engineered ECM based on combinatorial polyelectrolyte multilayer films

(2012) Miloslav Sailer et al.   BIOMATERIALS

A 3-D organoid kidney culture model engineered for high-throughput nephrotoxicity assays

(2012) Anna I. Astashkina et al.   BIOMATERIALS

Characterising the tumour morphological response to therapeutic intervention: an ex vivo model

(2012) A. Savage et al.   Disease Models & Mechanisms

Development and validation of a three-dimensional in vitro model for uterine leiomyoma and patient-matched myometrium

(2012) Minnie Malik et al.   FERTILITY AND STERILITY

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

In Vivo Maturation of Functional Renal Organoids Formed from Embryonic Cell Suspensions

(2012) C. Xinaris et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Recapitulating tumour microenvironment in chitosan-gelatin three-dimensional scaffolds: an improved in vitro tumour model

(2012) N. Arya et al.   Journal of the Royal Society Interface

RAIN-Droplet: a novel 3D in vitro angiogenesis model

(2012) Benjamin D Zeitlin et al.   LABORATORY INVESTIGATION

Construction of a Microstructured Collagen Membrane Mimicking the Papillary Dermis Architecture and Guiding Keratinocyte Morphology and Gene Expression

(2012) Gerwen Lammers et al.   MACROMOLECULAR BIOSCIENCE

Fabrication of functional three-dimensional tissues by stacking cell sheets in vitro

(2012) Yuji Haraguchi et al.   Nature Protocols

Revisiting lab-on-a-chip technology for drug discovery

(2012) Pavel Neužil et al.   NATURE REVIEWS DRUG DISCOVERY

A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity

(2012) Anna Astashkina et al.   PHARMACOLOGY & THERAPEUTICS

Human Tumor Cells Induce Angiogenesis through Positive Feedback between CD147 and Insulin-Like Growth Factor-I

(2012) Yanke Chen et al.   PLoS One

Cell Stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells

(2012) Wenwei Xu et al.   PLoS One

Vorinostat Eliminates Multicellular Resistance of Mesothelioma 3D Spheroids via Restoration of Noxa Expression

(2012) Dario Barbone et al.   PLoS One

Microfluidics separation reveals the stem-cell-like deformability of tumor-initiating cells

(2012) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effective enrichment of cholangiocarcinoma secretomes using the hollow fiber bioreactor culture system

(2012) Churat Weeraphan et al.   TALANTA

Determination of Drug Toxicity Using 3D Spheroids Constructed From an Immortal Human Hepatocyte Cell Line

(2012) Stephen J. Fey et al.   TOXICOLOGICAL SCIENCES

Bioprinting for stem cell research

(2012) Savas Tasoglu et al.   TRENDS IN BIOTECHNOLOGY

Two-photon polymerization-generated and micromolding-replicated 3D scaffolds for peripheral neural tissue engineering applications

(2012) A Koroleva et al.   Biofabrication

Toward engineering functional organ modules by additive manufacturing

(2012) Francoise Marga et al.   Biofabrication

Increasing extracellular matrix collagen level and MMP activity induces cyst development in polycystic kidney disease

(2012) Bin Liu et al.   BMC Nephrology

Preserved liver-specific functions of hepatocytes in 3D co-culture with endothelial cell sheets

(2011) Kyungsook Kim et al.   BIOMATERIALS

Towards automated production and drug sensitivity testing using scaffold-free spherical tumor microtissues

(2011) Maren Drewitz et al.   Biotechnology Journal

Integration of intra- and extravasation in one cell-based microfluidic chip for the study of cancer metastasis

(2011) Min Kyeong Shin et al.   LAB ON A CHIP

In vitro three-dimensional (3D) models in cancer research: An update

(2011) Lauren C. Kimlin et al.   MOLECULAR CARCINOGENESIS

Artificial niche microarrays for probing single stem cell fate in high throughput

(2011) Samy Gobaa et al.   NATURE METHODS

A Multifunctional 3D Co-Culture System for Studies of Mammary Tissue Morphogenesis and Stem Cell Biology

(2011) Jonathan J. Campbell et al.   PLoS One

Using High-Throughput Immunoblotting to Identify Proteins Involved in the Differentiation of ES Cells along the Hair Follicle Lineage in Vitro

(2011) Tammy-Claire Troy et al.   Stem Cell Reviews and Reports

Organ-Specific Scaffolds for In Vitro Expansion, Differentiation, and Organization of Primary Lung Cells

(2011) Yulia Shamis et al.   TISSUE ENGINEERING PART C-METHODS

Microengineering methods for cell-based microarrays and high-throughput drug-screening applications

(2011) Feng Xu et al.   Biofabrication

Three-dimensional microstructured tissue scaffolds fabricated by two-photon laser scanning photolithography

(2010) Tseng Ming Hsieh et al.   BIOMATERIALS

Development of a 3D human in vitro skin co-culture model for detecting irritants in real-time

(2010) I. Cantòn et al.   BIOTECHNOLOGY AND BIOENGINEERING

Multicellular tumor spheroids: An underestimated tool is catching up again

(2010) Franziska Hirschhaeuser et al.   JOURNAL OF BIOTECHNOLOGY

3D Hepatic Cultures Simultaneously Maintain Primary Hepatocyte and Liver Sinusoidal Endothelial Cell Phenotypes

(2010) Yeonhee Kim et al.   PLoS One

A Modular Approach to Cardiac Tissue Engineering

(2010) Brendan M. Leung et al.   TISSUE ENGINEERING PART A

The cryopreservation of composite tissues

(2010) Joseph Bakhach   Organogenesis

Anterior cruciate ligament regeneration using mesenchymal stem cells and silk scaffold in large animal model

(2009) Hongbin Fan et al.   BIOMATERIALS

Dissecting coronary angiogenesis: 3D co-culture of cardiomyocytes with endothelial or mesenchymal cells

(2009) Luciana R. Garzoni et al.   EXPERIMENTAL CELL RESEARCH

Transport-mediated angiogenesis in 3D epithelial coculture

(2009) Ryo Sudo et al.   FASEB JOURNAL

Layered implantation of myoblast sheets attenuates adverse cardiac remodeling of the infarcted heart

(2009) Naosumi Sekiya et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Bioengineered Three-Dimensional Physiological Model of Colonic Longitudinal Smooth Muscle In Vitro

(2009) Shreya Raghavan et al.   TISSUE ENGINEERING PART C-METHODS

3-D Tumor Model forIn VitroEvaluation of Anticancer Drugs

(2008) Jayme L. Horning et al.   MOLECULAR PHARMACEUTICS

Opportunities and challenges in ovarian cancer research, a perspective from the 11th Ovarian cancer action/HHMT Forum, Lake Como, March 2007

(2007) Alan Ashworth et al.   GYNECOLOGIC ONCOLOGY