Discovery and therapeutic potential of kinin receptor antagonists

Orally Active Peptidic Bradykinin B1 Receptor Antagonists Engineered from a Cyclotide Scaffold for Inflammatory Pain Treatment

(2012) Clarence T. T. Wong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and synthesis of novel sulfonamide-containing bradykinin hB2 receptor antagonists. Synthesis and structure-relationships of α,α-tetrahydropyranylglycine

(2012) Christopher I. Fincham et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inflammatory muscle pain is dependent on the activation of kinin B1 and B2 receptors and intracellular kinase pathways

(2012) FC Meotti et al.   BRITISH JOURNAL OF PHARMACOLOGY

Kinin receptors as targets for cancer therapy

(2012) Carlos D Figueroa et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

From Bradykinin B2 Receptor Antagonists to Orally Active and Selective Bradykinin B1 Receptor Antagonists

(2012) Martine Barth et al.   JOURNAL OF MEDICINAL CHEMISTRY

Kinin-mediated inflammation in neurodegenerative disorders

(2012) Ibeth Guevara-Lora   NEUROCHEMISTRY INTERNATIONAL

N-terminal extended conjugates of the agonists and antagonists of both bradykinin receptor subtypes: Structure–activity relationship, cell imaging using ligands conjugated with fluorophores and prospect for functionally active cargoes

(2012) Lajos Gera et al.   PEPTIDES

Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking

(2011) Kerstin Göbel et al.   JOURNAL OF AUTOIMMUNITY

Design of Fluorescent Bradykinin Analogs: Application to Imaging of B2 Receptor-Mediated Agonist Endocytosis and Trafficking and Angiotensin-Converting Enzyme

(2011) L. Gera et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Bradykinin receptor 1 activation exacerbates experimental focal and segmental glomerulosclerosis

(2011) Rafael L. Pereira et al.   KIDNEY INTERNATIONAL

The Role of Kinin Receptors in Preventing Neuroinflammation and Its Clinical Severity during Experimental Autoimmune Encephalomyelitis in Mice

(2011) Rafael C. Dutra et al.   PLoS One

The Role of Bradykinin and the Effect of the Bradykinin Receptor Antagonist Icatibant in Porcine Sepsis

(2011) Andreas Barratt-Due et al.   SHOCK

Activation of kinin B1 receptor increases the release of metalloproteases-2 and -9 from both estrogen-sensitive and -insensitive breast cancer cells

(2010) Pamela Ehrenfeld et al.   CANCER LETTERS

Vascular smooth muscle contractility assays for inflammatory and immunological mediators

(2010) François Marceau et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of Bradykinin Receptor B1 Protects Mice from Focal Brain Injury by Reducing Blood–Brain Barrier Leakage and Inflammation

(2010) Furat Raslan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Bradykinin B1 Receptor Antagonists as Potential Therapeutic Agents for Pain

(2010) Hui Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Icatibant, a New Bradykinin-Receptor Antagonist, in Hereditary Angioedema

(2010) Marco Cicardi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Blockade of bradykinin B2 receptor more effectively reduces postischemic blood–brain barrier disruption and cytokines release than B1 receptor inhibition

(2009) Jingjing Su et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stimulation of the bradykinin B1 receptor induces the proliferation of estrogen-sensitive breast cancer cells and activates the ERK1/2 signaling pathway

(2009) Luis Molina et al.   BREAST CANCER RESEARCH AND TREATMENT

Bradykinin receptor antagonists – a review of the patent literature 2005 – 2008

(2009) Christopher I Fincham et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The Role of Bradykinin B1 and B2 Receptors for Secondary Brain Damage after Traumatic Brain Injury in Mice

(2009) Raimund Trabold et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Kinin B1 receptor activation turns on exocytosis of matrix metalloprotease-9 and myeloperoxidase in human neutrophils: involvement of mitogen-activated protein kinase family

(2009) Pamela Ehrenfeld et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Fluorescent Ligands of the Bradykinin B1 Receptors: Pharmacologic Characterization and Application to the Study of Agonist-Induced Receptor Translocation and Cell Surface Receptor Expression

(2009) M.-T. Bawolak et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system

(2009) Ulf Schulze-Topphoff et al.   NATURE MEDICINE

Anatibant®, a selective non-peptide bradykinin B2 receptor antagonist, reduces intracranial hypertension and histopathological damage after experimental traumatic brain injury

(2009) Klaus Zweckberger et al.   NEUROSCIENCE LETTERS

Kallikreins, kininogens and kinin receptors on circulating and synovial fluid neutrophils: role in kinin generation in rheumatoid arthritis

(2009) B. Cassim et al.   RHEUMATOLOGY

The BRAIN TRIAL: a randomised, placebo controlled trial of a Bradykinin B2 receptor antagonist (Anatibant) in patients with traumatic brain injury

(2009) Haleema Shakur et al.   Trials

Expression of tissue and plasma kallikreins and kinin B1 and B2 receptors in lung cancer

(2008) Jessica Chee et al.   BIOLOGICAL CHEMISTRY

Activation of kinin B1receptor triggers differentiation of cultured human keratinocytes

(2008) C.E. Matus et al.   BRITISH JOURNAL OF DERMATOLOGY

Delayed blockade of the kinin B1 receptor reduces renal inflammation and fibrosis in obstructive nephropathy

(2008) J. Klein et al.   FASEB JOURNAL

A fluorescent version of the bradykinin B2 receptor antagonist B-9430: Pharmacological characterization and use in live cell imaging

(2008) Marie-Thérèse Bawolak et al.   PEPTIDES

Brabykinin B1 Receptor Antagonism Is Beneficial in Renal Ischemia-Reperfusion Injury

(2008) Pamella H. M. Wang et al.   PLoS One

Blockade of Bradykinin Receptor B1 but Not Bradykinin Receptor B2 Provides Protection From Cerebral Infarction and Brain Edema

(2008) Madeleine Austinat et al.   STROKE