期刊
EXPERT OPINION ON DRUG DISCOVERY
卷 6, 期 7, 页码 755-769出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/17460441.2011.586028
关键词
animal models; anxiety; behavioral phenotyping; bioinformatics; neurobehavioral domains
资金
- Tulane University
Areas covered: In this article, the authors discuss and emphasize the importance of high-throughput multi-domain neurophenotyping based on the latest developments in video-tracking and bioinformatics. Additionally, the authors also explain how bioinformatics can provide new insight into the neural substrates of brain disorders and its benefit for drug discovery. Expert opinion: The throughput and utility of animal models of anxiety and other brain disorders can be markedly increased by a number of ways: i) analyzing systems of several domains and their interplay in a wider spectrum of model species; ii) using a larger number of end points generated by video-tracking tools; iii) correlating behavioral data with genomic, proteomic and other physiologically relevant markers using online databases and iv) creating molecular network-based models of anxiety to identify new targets for drug design and discovery. Experimental models utilizing bioinformatics tools and online databases will not only improve our understanding of both gene--behavior interactions and complex trait interconnectivity but also highlight new targets for novel anxiolytic drugs.
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