标题
Update on aurora kinase targeted therapeutics in oncology
作者
关键词
-
出版物
Expert Opinion on Drug Discovery
Volume 6, Issue 3, Pages 291-307
出版商
Informa Healthcare
发表日期
2011-02-23
DOI
10.1517/17460441.2011.555395
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Aurora Kinase Inhibitor PHA-739358 Suppresses Growth of Hepatocellular Carcinoma In Vitro and in a Xenograft Mouse Model
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- Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state
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- A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma
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- Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor, ENMD-2076, against multiple myeloma
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- Preclinical Evaluation of AMG 900, a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines
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- Outcomes for Children and Adolescents With Cancer: Challenges for the Twenty-First Century
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- Antiproliferative effect of Aurora kinase targeting in mesothelioma
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- Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer
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- MLN8054, an Inhibitor of Aurora A Kinase, Induces Senescence in Human Tumor Cells Both In vitro and In vivo
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- The FLT3 Internal Tandem Duplication Mutation Is a Secondary Target of the Aurora B Kinase Inhibitor AZD1152-HQPA in Acute Myelogenous Leukemia Cells
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- PF-03814735, an Orally Bioavailable Small Molecule Aurora Kinase Inhibitor for Cancer Therapy
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- MK-5108, a Highly Selective Aurora-A Kinase Inhibitor, Shows Antitumor Activity Alone and in Combination with Docetaxel
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- Mitotic drivers—inhibitors of the Aurora B Kinase
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- A Phase I Dose-Escalation Study of Danusertib (PHA-739358) Administered as a 24-Hour Infusion with and without Granulocyte Colony-Stimulating Factor in a 14-Day Cycle in Patients with Advanced Solid Tumors
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- Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen
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- DNA Repair
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- Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells
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- GSK1070916, a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models
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- The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model
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- ZM447439, a Novel Promising Aurora Kinase Inhibitor, Provokes Antiproliferative and Proapoptotic Effects Alone and in Combination with Bio- and Chemotherapeutic Agents in Gastroenteropancreatic Neuroendocrine Tumor Cell Lines
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- Identification of genes that confer tumor cell resistance to the Aurora B kinase inhibitor, AZD1152
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- Discovery of a potent and selective Aurora kinase inhibitor
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- Vorinostat synergistically potentiates MK-0457 lethality in chronic myelogenous leukemia cells sensitive and resistant to imatinib mesylate
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- Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I
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- The selective Aurora B kinase inhibitor AZD1152 is a potential new treatment for multiple myeloma
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- Activity of a novel Aurora kinase inhibitor against the T315I mutant form of BCR-ABL:In vitroandin vivostudies
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- Aurora Kinases as Anticancer Drug Targets
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- Aurora kinases
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- Effects of the Aurora kinase inhibitor VX-680 on anaplastic thyroid cancer-derived cell lines
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- Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts
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- Aurora kinase A inhibition and paclitaxel as targeted combination therapy for head and neck squamous cell carcinoma
- (2008) Abhijit Mazumdar et al. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
- The Aurora kinase inhibitor VE-465 has anticancer effects in pre-clinical studies of human hepatocellular carcinoma
- (2008) Zhong-Zhe Lin et al. JOURNAL OF HEPATOLOGY
- Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity†
- (2008) Steven Howard et al. JOURNAL OF MEDICINAL CHEMISTRY
- Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells
- (2008) Robert Evans et al. LEUKEMIA & LYMPHOMA
- Aurora kinases as targets for cancer therapy
- (2007) Giannis Mountzios et al. CANCER TREATMENT REVIEWS
- Aurora kinase small molecule inhibitor destroys mitotic spindle, suppresses cell growth, and induces apoptosis in oral squamous cancer cells
- (2007) Caobing Pan et al. ORAL ONCOLOGY
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