Human kinome drug discovery and the emerging importance of atypical allosteric inhibitors

The Current Status of Drug Discovery Against the Human Kinome

(2009) Richard M. Eglen et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Identification of small-molecule inhibitors of the JIP–JNK interaction

(2009) Tracy Chen et al.   BIOCHEMICAL JOURNAL

Development of a Fluorescent-Tagged Kinase Assay System for the Detection and Characterization of Allosteric Kinase Inhibitors

(2009) Jeffrey R. Simard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell cycle kinases as therapeutic targets for cancer

(2009) Silvia Lapenna et al.   NATURE REVIEWS DRUG DISCOVERY

Trapping Moving Targets with Small Molecules

(2009) G. M. Lee et al.   SCIENCE

Development of thioquinazolinones, allosteric Chk1 kinase inhibitors

(2008) Antonella Converso et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

High-Content Analysis of Kinase Activity in Cells

(2008) Fabio Gasparri et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

An Overview of Drug Screening Using Primary and Embryonic Stem Cells

(2008) Richard Eglen et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

The PI3K/Akt Pathway: Recent Progress in the Development of ATP-Competitive and Allosteric Akt Kinase Inhibitors

(2008) Craig Lindsley et al.   CURRENT CANCER DRUG TARGETS

Doing more than just the structure—structural genomics in kinase drug discovery

(2008) Brian D Marsden et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Small molecular weight protein–protein interaction antagonists—an insurmountable challenge?

(2008) Alexander Dömling   CURRENT OPINION IN CHEMICAL BIOLOGY

Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site

(2008) Mia Rushe et al.   STRUCTURE

CDK inhibitors in cancer therapy: what is next?

(2007) Marcos Malumbres et al.   TRENDS IN PHARMACOLOGICAL SCIENCES