Review
Chemistry, Physical
Jiahao Shi, Bin Ma, Yuhe Zhang, Haiyang Yong, Zhili Li, A. Sigen, Xiaobei Huang, Dezhong Zhou
Summary: Cancer therapy is a global challenge, but a variety of promising anticancer therapeutics have been developed. However, their direct administration often fails to achieve the desired efficacy due to low bioavailability and poor tissue selectivity. Polymers offer advantages for drug delivery, yet are generally poorly targeted to the tumor microenvironment (TME). The relatively lower acidity of the TME provides a specific trigger for the development of polymers for targeted delivery, and this article summarizes the strategies, mechanisms, and applications of acidity-sensitive polymers for delivering various anticancer therapeutics.
CHEMISTRY OF MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
De-Xiang Zhang, Terence Tieu, Lars Esser, Marcin Wojnilowicz, Chieh-Hua Lee, Anna Cifuentes-Rius, Helmut Thissen, Nicolas H. Voelcker
Summary: In this study, a method for modifying the internal and external surfaces of porous silicon nanoparticles (pSiNPs) was developed. The modified pSiNPs showed excellent colloidal stability in a cell culture medium and the drug release kinetics could be fine-tuned by the combination of internal and external surface modifications. Moreover, the drug-loaded and peptide-functionalized nanoparticles exhibited enhanced cytotoxicity against prostate carcinoma cells.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Lingli Jin, Yanwen Xu, Fengjiao Chen, Dingle Yu, Hongze Liang, Zhenjiang Liang, Ziyu Liu, Haiyan Li, Junying Liu, Hui Tan, Lingling Zhao
Summary: A mitochondria-targeted and pH-triggered charge-convertible polymeric micellar system was developed for doxorubicin delivery and targeted anticancer therapy. It showed sustained drug release and enhanced cellular uptake, accumulation in mitochondria, and efficient release of doxorubicin in tumor cells.
MATERIALS & DESIGN
(2022)
Article
Polymer Science
Wojciech Raj, Krzysztof Jerczynski, Mahdi Rahimi, Ewa Pavlova, Miroslav Slouf, Agata Przekora, Joanna Pietrasik
Summary: In this study, a series of vitamin E-based TPGS-poly(2-(dimethylamino)ethyl methacrylate)-b-poly(3-vinyl benzaldehyde) block copolymer micelles were synthesized, and the anticancer drug DOX was loaded within the micelles. The micelles demonstrated potential as drug delivery systems for cancer treatment, with pH-responsive characteristics. However, increasing the hydrophobic block polymerization degree reduced the cytotoxicity of the micelles.
Article
Chemistry, Applied
Alexandre C. C. Sousa, Adolfo I. B. Romo, Raimundo R. Almeida, Aierta C. C. Silva, Lillian M. U. Fechine, Debora H. A. Brito, Rafael M. Freire, Daniel P. Pinheiro, Larissa M. R. Silva, Otilia D. L. Pessoa, Juliano C. Denardin, Claudia Pessoa, Nagila M. P. S. Ricardo
Summary: Magnetic nanocomposites were synthesized to target the delivery of hydrophilic bioactives using a magnetic field, demonstrating potential anticancer activity and prolonged drug release profile.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Multidisciplinary
Mengmeng Long, Xuemeng Liu, Xu Huang, Min Lu, Xiaomei Wu, Lingyan Weng, Qiuping Chen, Xueting Wang, Li Zhu, Zhongping Chen
Summary: A bone-targeted and hypoxia-responsive polymeric micelle system was developed for effective treatment of bone metastatic prostate cancer, demonstrating significant inhibition of tumor growth in metastatic bone, promotion of osteoblast activity, relief of bone pain, and prolonged survival time.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Pharmacology & Pharmacy
Magdalena Jurczyk, Katarzyna Jelonek, Monika Musial-Kulik, Artur Beberok, Dorota Wrzesniok, Janusz Kasperczyk
Summary: Cancer treatment is a major challenge globally, with nanoparticle drug delivery systems playing a crucial role in avoiding the side effects of traditional chemotherapy. Future nanomedicine should focus on active targeting and dual-targeting systems for better efficacy in cancer therapy.
Article
Biotechnology & Applied Microbiology
Meng Du, Ting Wang, Renjie Feng, Penghui Zeng, Zhiyi Chen
Summary: Bacteria-driven biohybrid microbots have potential in cancer treatment, but the precise control of drug release at the tumor site remains a challenge. To overcome this, the ultrasound-responsive SonoBacteriaBot (DOX-PFP-PLGA@EcM) was proposed. It showed high tumor-targeting efficiency, controlled drug release capability, and ultrasound imaging. DOX-PFP-PLGA@EcM can efficiently accumulate in tumors and has significant potential applications for therapeutic drug delivery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Weihe Yao, Chenyu Liu, Ning Wang, Hengjun Zhou, Hailiang Chen, Weihong Qiao
Summary: Targeted multi-responsive drug delivery systems with MRI capabilities were successfully synthesized, showing high stability and biocompatibility in vivo with excellent drug targeting effects.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Jiakun Tang, Ye Liu, Dongmei Qi, Lan Yang, Hui Chen, Chenhui Wang, Xuli Feng
Summary: The study introduces an efficient intranuclear protein delivery nanoplatform based on protein co-assembly, utilizing modified RNase A and WLC to enhance the delivery of multiple proteins into the nucleus, leading to significantly improved antitumor efficacy in vitro and in vivo.
Article
Chemistry, Multidisciplinary
Hao Zhang, Ze Gao, Xiaoxiao Li, Lu Li, Sujuan Ye, Bo Tang
Summary: A multifunctional drug delivery system with triple-interlocked mechanism is developed for precise drug release and photothermal therapy, demonstrating potential for effective cancer treatment.
Article
Biophysics
Jingmou Yu, Liangliang Wang, Yun Ling, Xin Xiao, Juntao Gong, Hongguang Jin, Jing Xu, Pu Chen, Xin Xie, Lei Zhang
Summary: In this study, novel polymeric nanoparticles targeting dual receptors and responding to reducing conditions for drug release were developed for the treatment of triple-negative breast cancer. The bioresponsive drug release of the nanoparticles was demonstrated, and it was found that they effectively targeted specific receptors both in vitro and in vivo. The nanoparticles showed higher cytotoxicity and cellular uptake compared to unmodified drug-containing micelles, and they exhibited the strongest suppression of tumor growth in a mouse model. These findings suggest that amphiphilic nanoparticles can serve as a targeted and intelligent delivery vehicle for triple-negative breast cancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Engineering, Biomedical
Hua-Zhen Xu, Tong-Fei Li, Yan Ma, Ke Li, Quan Zhang, Yong-Hong Xu, Yu-Cai Zhang, Li Zhao, Xiao Chen
Summary: Photodynamic therapy (PDT) is a promising treatment for glioblastoma (GBM), but limited accumulation of photosensitizer in the tumor hinders its success. This study proposes a strategy to use platelets as carriers for a photo-controlled release of a nano-photosensitizer, demonstrating its efficacy in vitro and in vivo.
Article
Nanoscience & Nanotechnology
Jaehyun Park, Seokhee Jo, Yeong Mi Lee, Gurusamy Saravanakumar, Junseok Lee, Dongsik Park, Won Jong Kim
Summary: The study utilized specific enzymes with high activity in cancer for cancer diagnosis and tumor-targeted drug delivery. NQO1, an over-expressed enzyme in certain tumor types, inhibits oxidative stress and reacts with QPA to induce micellar structure dissociation for drug release. These findings suggest that NQO1-responsive polymeric micelles have potential for improving therapeutic efficacy in anticancer drug delivery.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Applied
Min Li, Yinan Zhao, Jiao Sun, Huiying Chen, Zhanbiao Liu, Kexin Lin, Pengfei Ma, Wenjun Zhang, Yuhong Zhen, Shufen Zhang, Shubiao Zhang
Summary: Polymer-based prodrug nanocarriers with tumor-targeting and controlled-release properties are highly desirable for improving cancer treatment. Hyaluronic acid (HA), known for its excellent biocompatibility and targeting ability for CD44, has been suggested as a carrier for delivering drugs with poor solubility and high toxicity. In this study, podophyllotoxin (PPT) was conjugated to HA through ester and disulfide linkages to create a pH and reduction-responsive prodrug (HA-S-S-PPT). Micelles self-assembled from HA-S-S-PPT efficiently accumulated at the tumor site due to HA receptor-mediated endocytosis. These micelles exhibited 33.1% higher cumulative release compared to HA-NH-CO-PPT micelles, which were only sensitive to pH. HA-S-S-PPT micelles demonstrated excellent antitumor activity in vivo, with a tumor inhibition rate of 92%, significantly higher than that of HA-NH-CO-PPT micelles (65%), and minimal systemic toxicity. This controllable-targeting nanoparticle system presents a potential platform for the clinical application of PPT.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Kai Zhou, Jing-wei Zhang, Qi-zhi Wang, Wen-yue Liu, Jia-li Liu, Lan Yao, Ming-min Cai, Sui-ying Ni, Qing-yun Cai, Guang-ji Wang, Fang Zhou
ACTA PHARMACOLOGICA SINICA
(2019)
Article
Chemistry, Analytical
Xiaoliang Jin, Fang Zhou, Yan Liu, Chen Cheng, Lan Yao, Yuanwei Jia, Guangji Wang, Jingwei Zhang
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2018)
Article
Biochemistry & Molecular Biology
Wenjie Wang, Qingyun Cai, Fang Zhou, Jiali Liu, Xiaoliang Jin, Ping Ni, Meng Lu, Guangji Wang, Jingwei Zhang
Article
Oncology
Wenyue Liu, Jingwei Zhang, Xuequan Yao, Chao Jiang, Ping Ni, Lingge Cheng, Jiali Liu, Suiying Ni, Qianying Chen, Qingran Li, Kai Zhou, Guangji Wang, Fang Zhou
Article
Pharmacology & Pharmacy
Jiali Liu, Xiaoliang Jin, Fang Zhou, Hongzhu Chen, Wenjie Wang, Yan Liu, Guangji Wang, Kun Hao, Jingwei Zhang
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Review
Pharmacology & Pharmacy
Siqi Feng, Huan Wang, Jiali Liu, Jiye Aa, Fang Zhou, Guangji Wang
PHARMACOLOGICAL RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Jiali Liu, Qingyun Cai, Wenjie Wang, Meng Lu, Jianming Liu, Fang Zhou, Minjie Sun, Guangji Wang, Jingwei Zhang
Article
Pharmacology & Pharmacy
Chongjin Zhong, Chao Jiang, Suiying Ni, Qizhi Wang, Lingge Cheng, Huan Wang, Qixiang Zhang, Wenyue Liu, Jingwei Zhang, Jiali Liu, Mulan Wang, Min Jin, Peiqiang Shen, Xuequan Yao, Guangji Wang, Fang Zhou
ACTA PHARMACEUTICA SINICA B
(2020)
Article
Plant Sciences
Lingge Cheng, Wenyue Liu, Chongjin Zhong, Ping Ni, Suiying Ni, Qizhi Wang, Qixiang Zhang, Jingwei Zhang, Jiali Liu, Meijuan Xu, Xuequan Yao, Xiaobo Cen, Guangji Wang, Chao Jiang, Fang Zhou
Summary: SMI can remodel the balance of pro- and anti-angiogenic factors to promote tumor vessel normalization, enhancing drug delivery and anti-tumor effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xiao-yang Chen, Fei Qian, Yao-yao Wang, Yan Liu, Yuan Sun, Wei-bin Zha, Kun Hao, Fang Zhou, Guang-ji Wang, Jing-wei Zhang
Summary: The study demonstrated that 20(S)-Rh2 enhances the therapeutic effect of levofloxacin against Staphylococcus aureus by increasing drug accumulation within cells, inhibiting efflux transporters, and stabilizing the drug-target complex in lysosome-like acidic conditions.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Pharmacology & Pharmacy
Hua Sang, Jiali Liu, Fang Zhou, Xiaofang Zhang, Jingwei Zhang, Yazhong Liu, Guangji Wang, Hui Ye
Summary: This study introduces a new method called Target-Responsive Subcellular Catabolism (TARSC) to investigate the efficiency and toxicity of ADC degradation, as well as the protein reactions involved in this process. The results suggest that TARSC analysis is an effective tool for biosimilarity assessment and for studying the functional proteins required for ADC degradation.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Materials Science, Biomaterials
He Dong, Xiaodan Hong, Yingjiao He, Zhengxiang Bao, Ying Zhang, Shiyang Shen, Guangji Wang, Jingwei Zhang, Ran Mo
Summary: Hepatitis B is a major global public health burden and current therapeutic strategies have limitations. In this study, a carrier-free metal-organic hybrid nanoassembly loaded with an anti-viral agent and an anti-inflammatory compound was developed. The nanoassembly demonstrated enhanced anti-HBV effect and alleviated inflammation in mouse models of hepatitis B.
BIOMATERIALS SCIENCE
(2022)