Emerging methods for identifying monoclonal antibodies with low propensity to self-associate during the early discovery process

Which are the antibodies to watch in 2013?

(2013) Janice M. Reichert   mAbs

High throughput detection of antibody self-interaction by bio-layer interferometry

(2013) Tingwan Sun et al.   mAbs

Rapid Analysis of Antibody Self-Association in Complex Mixtures Using Immunogold Conjugates

(2013) Shantanu V. Sule et al.   MOLECULAR PHARMACEUTICS

Weak Interactions Govern the Viscosity of Concentrated Antibody Solutions: High-Throughput Analysis Using the Diffusion Interaction Parameter

(2012) Brian D. Connolly et al.   BIOPHYSICAL JOURNAL

Solubility evaluation of murine hybridoma antibodies

(2012) Stacey Spencer et al.   mAbs

Marketed therapeutic antibodies compendium

(2012) Janice M. Reichert   mAbs

Solution pH That Minimizes Self-Association of Three Monoclonal Antibodies Is Strongly Dependent on Ionic Strength

(2012) Shantanu V. Sule et al.   MOLECULAR PHARMACEUTICS

Mechanisms of self-association of a human monoclonal antibody CNTO607

(2012) Deidra Bethea et al.   PROTEIN ENGINEERING DESIGN & SELECTION

High-Throughput Analysis of Concentration-Dependent Antibody Self-Association

(2011) Shantanu V. Sule et al.   BIOPHYSICAL JOURNAL

A critical evaluation of self-interaction chromatography as a predictive tool for the assessment of protein–protein interactions in protein formulation development: A case study of a therapeutic monoclonal antibody

(2010) Virginie Le Brun et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Comparative Effects of pH and Ionic Strength on Protein–Protein Interactions, Unfolding, and Aggregation for IgG1 Antibodies

(2010) Erinc Sahin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Intermolecular Interactions of IgG1 Monoclonal Antibodies at High Concentrations Characterized by Light Scattering

(2010) Thomas M. Scherer et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Biospecific protein immobilization for rapid analysis of weak protein interactions using self-interaction nanoparticle spectroscopy

(2009) Aditya N. Bengali et al.   BIOTECHNOLOGY AND BIOENGINEERING

Understanding and Modulating Opalescence and Viscosity in a Monoclonal Antibody Formulation

(2009) Branden A. Salinas et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Specific interactions in high concentration antibody solutions resulting in high viscosity

(2009) Sandeep Yadav et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Cross-Interaction Chromatography: A Rapid Method to Identify Highly Soluble Monoclonal Antibody Candidates

(2009) Steven A. Jacobs et al.   PHARMACEUTICAL RESEARCH

Reversible Self-Association of a Concentrated Monoclonal Antibody Solution Mediated by Fab–Fab Interaction That Impacts Solution Viscosity

(2008) Sonoko Kanai et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Self-Interaction Nanoparticle Spectroscopy:  A Nanoparticle-Based Protein Interaction Assay

(2008) Peter M. Tessier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein self-interaction chromatography on a microchip

(2008) Kedar Deshpande et al.   LAB ON A CHIP