Article
Medicine, Research & Experimental
Shahin Alizadeh-Fanalou, Mohsen Khosravi, Fatemeh Alian, Shirin Rokhsartalb-Azar, Ali Nazarizadeh, Maryam Karimi-Dehkordi, Forogh Mohammadi
Summary: miR-1297, a microRNA with dual functions, exhibits abnormal expression in various human cancers, acting as both a tumor suppressor and an oncogene.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biology
Junaid Ali Shah, Saadullah Khattak, Mohd Ahmar Rauf, Yong Cai, Jingji Jin
Summary: miRNAs are small non-coding RNA transcripts that regulate gene expression in cells, including tumorigenesis. The miR-371-373 genes are found to be abnormally expressed in various cancers and may serve as molecular biomarkers for cancer diagnosis and prevention. Further studies linking miR-371-373 functions to tumorigenesis suggest their potential applications in cancer diagnosis and treatment.
Review
Oncology
Suliman Khan, De-Yu Zhang, Ji-Yu Zhang, Mian Khizar Hayat, Jingli Ren, Safyan Nasir, Muhammad Fawad, Qian Bai
Summary: The expression and function of miRNAs play a crucial role in the development of HCC, affecting the biological behavior and clinical pathological features of liver cancer. Despite the unclear regulatory mechanisms, the potential of miRNA-based therapy for HCC warrants further exploration.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Maria Victoria Castro, Pablo Lopez-Bergami
Summary: ROR1 and ROR2 are Wnt receptors, and they are associated with tumor progression. While ROR1 always promotes tumorigenesis, ROR2 has a complex role in different tumor types, either promoting or inhibiting tumor progression.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Antonino B. D'Assoro, Roberto Leon-Ferre, Eike-Benjamin Braune, Urban Lendahl
Summary: The Notch signaling pathway is important for normal development, but dysregulation of this pathway is associated with various types of tumors. In addition to its role in tumor cells, Notch signaling also affects non-mutated cells in the tumor microenvironment and their interactions with tumor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Da Young Lee, Jung Nyeo Chun, Minsoo Cho, Insuk So, Ju-Hong Jeon
Summary: E2F8 is a multifaceted transcription factor that is involved in various aspects of cancer development and progression. It has the ability to promote cancer cell proliferation and survival while also exhibiting tumor-suppressing activity. This review highlights the recent progress in understanding the role of E2F8 in human cancers and its implications for developing therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Medicine, Research & Experimental
Jianan Xu, Yuanyuan Sun, Weineng Fu, Shuang Fu
Summary: Myc target 1 (MYCT1), located at 6q25.2, is a crucial player in cancer development with widely distributed expression in cells and variable subcellular localization across different cancer types. It is regulated by multiple transcription factors and aberrant expression of MYCT1 impacts key biological processes and tumor immune responses in cancer cells. Despite some debated functions, MYCT1 holds undeniable significance in cancer development. This review aims to comprehensively examine the relationship between MYCT1 and cancer, providing valuable insights for cancer diagnosis and treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Multidisciplinary Sciences
Fatemeh Tajik, Fatemeh Alian, Mohammad Yousefi, Ali Azadfallah, Aref Hoseini, Forogh Mohammadi, Maryam Karimi-Dehkordi, Shahin Alizadeh-Fanalou
Summary: miR-372 is a non-coding, single-stranded, endogenous RNA that regulates various biological processes by binding to 3'-UTR mRNAs and controlling gene expression at the post-transcriptional level. It has abnormal expression in many human malignancies, suggesting its role in carcinogenesis, where it can function both as an oncogene and a tumor suppressor.
Review
Biochemistry & Molecular Biology
Cheng Zou, Ying Wan, Lingjing He, Jin Hai Zheng, Yang Mei, Junfeng Shi, Min Zhang, Zhiqiang Dong, Dingxiao Zhang
Summary: RBPs are widely dysregulated in numerous human cancers, and RBM38, as a well-studied RBP, frequently plays a tumor-suppressive role in multiple human cancer types. By uncovering a spectrum of transcripts bound by RBM38, the diversity in its mechanisms of action in distinct biological contexts can be revealed, indicating the possibility of targeting RBM38 and its related pathways as therapeutic strategies against cancer.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Pathology
Soudeh Ghafouri-Fard, Arash Safarzadeh, Solmaz Hassani Fard Katiraei, Bashdar Mahmud Hussen, Mohammadreza Hajiesmaeili
Summary: This review article explores the functions of miR-328 in the development of human carcinogenesis and highlights the discrepancies in different studies, which may be attributed to different stages/grades of tumor tissues or other clinical characteristics.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pharmacology & Pharmacy
He Fang, Hanyang Li, Hang Zhang, Shu Wang, Shuang Xu, Li Chang, Yongsheng Yang, Ranji Cui
Summary: This article summarises the significance of HADH expression in tumors and its potential mechanisms of action in the onset and progression of certain cancers. It also describes the possible roles of HADH as a target and/or biomarker for the detection and treatment of various malignancies.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Ludek Zavesky, Eva Jandakova, Vit Weinberger, Veronika Hanzikova, Ondrej Slanar, Milada Kohoutova
Summary: This article focuses on the differential expression of miRNAs in ascitic fluid and their potential roles in ovarian cancer. Let-7b and miR-143 act as tumor suppressors, while miR-26a-5p and miR-145-5p have both tumor-suppressing and oncogenic roles. The role of miR-95-3p is still debated, and conflicting findings have been reported for miR-182-5p and miR-200c-3p.
Review
Pharmacology & Pharmacy
Zhiwen Fu, Liu Wang, Shijun Li, Fen Chen, Kathy Ka-Wai Au-Yeung, Chen Shi
Summary: miRNAs play a crucial role in cancer treatment by regulating gene expression and influencing the growth and survival of cancer cells. They are considered an attractive target for anticancer drug development and have shown promising results in research and therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Francisco Alejandro Lagunas-Rangel
Summary: KDM6B is a histone demethylase that can act as a tumor suppressor or an oncogene depending on the cellular context. This study summarizes the role of KDM6B in different oncological contexts, aiming to guide its clinical application.
Review
Oncology
Mohammad Taheri, Bashdar Mahmud Hussen, Sajad Najafi, Atefe Abak, Soudeh Ghafouri-Fard, Majid Samsami, Aria Baniahmad
Summary: ING genes are members of the tumor suppressor gene family and play important roles in regulating cell proliferation, apoptosis, and cellular senescence. They interact with chromatin structures and other proteins involved in biological processes such as cell cycle regulation, exerting their regulatory effects through epigenetic mechanisms. INGs have a role in restricting the proliferative and invasive potentials of normal cells and are particularly involved in cancer development and progression. However, further research and experimental confirmation are needed to validate these models.
CANCER CELL INTERNATIONAL
(2022)
Review
Immunology
Srinivasan Sabitha, Nagarajan Shobana, Pandurangan Prakash, Sathiyamoorthy Padmanaban, Mahendran Sathiyashree, Subramanian Saigeetha, Srikumar Chakravarthi, Saji Uthaman, In-Kyu Park, Antony Samrot
Summary: This article discusses the impact of the novel coronavirus on top nations worldwide and the vaccines used for prevention. It provides insight into different COVID-19 vaccine platforms, including their preparation, working, efficacy, and side effects.
Review
Medicine, General & Internal
Sang Hun Lee, Songsoo Yang, Inkyu Park, Yeong Cheol Im, Gyu Yeol Kim
Summary: This case report describes a 33-year-old pregnant woman who experienced a sudden onset of epigastric pain at 18 weeks of pregnancy due to a ruptured SAA. After emergent intervention and surgery, the woman recovered without complications and was discharged 15 days postoperatively, even though the fetus was found to be dead during resuscitation.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Chemistry, Multidisciplinary
Wei-Jin Zhang, Shuwei Li, Veena Vijayan, Jun Seok Lee, Sung Soo Park, Xiuguo Cui, Ildoo Chung, Jaejun Lee, Suk-kyun Ahn, Jung Rae Kim, In-Kyu Park, Chang-Sik Ha
Summary: In this study, a responsive nanoparticle system was designed for efficient chemotherapy drug delivery and antibacterial applications. The nanoparticles showed superior biocompatibility and stability, and exhibited excellent photothermal conversion efficiency and extinction coefficient. Additionally, the nanoparticles demonstrated both ROS-responsive and pH-responsive release performance of the chemotherapy drug, as well as high antibacterial activity.
Article
Nanoscience & Nanotechnology
Gihun Lee, Jungrak Choi, Junseong Ahn, Seokju Cho, Inkyu Park
Summary: Efforts are being made to develop low-power and high-efficiency technologies to reduce pollution in energy production worldwide due to the increasing damage caused by the recent climate crisis. One of the research areas focuses on mechano-responsive optical transmittance modulation technology for applications such as low-power sensors and smart windows. However, fabricating a piezotransmittance structure with a large-area production, high throughput, and good tunability is still challenging. An efficient fabrication method for a multi-layered piezo-transmittance structure has been presented, with tunability achieved through design parameters and surrogate models obtained from simulation and prediction models. Two energy-efficient applications have been demonstrated: a smart window with integrated hydraulic pump for indoor environment control and a telemetry system for remote pressure measurement.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Seunghwan Kim, Yong Suk Oh, Kwanghyoung Lee, Seongchan Kim, Woo-Youl Maeng, Kyung Su Kim, Ga-Been Kim, Seokjoo Cho, Hyeonseok Han, Hyunwoo Park, Mengqiu Wang, Raudel Avila, Zhaoqian Xie, Kabseok Ko, Jungrak Choi, Minkyu Je, Hyojin Lee, Sungho Lee, Jahyun Koo, Inkyu Park
Summary: A battery-free, wireless, cuff-type, implantable, multimodal physical sensing platform is introduced for continuous in vivo monitoring of temperature and strain from peripheral nerve injuries. The system enables power harvesting and data communication to multiple implanted devices wrapped around the nerve.
Article
Optics
Incheol Cho, Kichul Lee, Young Chul Sim, Jae-Seok Jeong, Minkyu Cho, Heechan Jung, Mingu Kang, Yong-Hoon Cho, Seung Chul Ha, Kuk-Jin Yoon, Inkyu Park
Summary: Electronic nose (e-nose) technology using chemoresistive sensors has been widely studied for its applications in smart factory and personal health monitoring. To address cross-reactivity issues, a novel sensing strategy based on a single micro-LED embedded photoactivated gas sensor has been proposed. This method utilizes time-variant illumination and a deep neural network for species and concentrations identification of various target gases, achieving high accuracy with low power consumption.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Gaabhin Ryu, Inkyu Park, Hyoungsoo Kim
Summary: In this study, the interfacial phenomena and characteristics observed at the interface between a liquid metal and continuous-phase liquids were introduced. Based on these results, various methods to fabricate liquid metal droplets with tunable surface properties were discussed. Finally, the potential applications of these techniques in state-of-the-art technologies including microfluidics, soft electronics, catalysts, and biomedicines were explored.
Proceedings Paper
Engineering, Electrical & Electronic
Mingu Kang, Incheol Cho, Inkyu Park
Summary: In this research, a humidity compensation method using a deep learning network was proposed to minimize the effect of humidity on semiconductor metal oxide (SMO) gas sensors. The SMO gas sensors were fabricated by depositing In2O3 on a suspended microheater platform, and gas tests were conducted under various humidity conditions using NO2 gas. The gas sensing data and humidity data were simultaneously used as input data of the deep learning network for real-time humidity compensation. Through this method, the accuracy of predicting the concentration of NO2 gas in different humidity conditions was successfully improved.
2023 IEEE 36TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, MEMS
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Kichul Lee, Mingu Kang, Inkyu Park
Summary: With the increasing interest in environmental pollution, indoor air quality, and industrial safety, the demand for gas sensors is rapidly rising. However, the conventional gas sensors have high power consumption and bulky size, limiting their utilization. To overcome this issue, a micro-sized, ultra-low-power LED gas sensor and an e-nose system using a convolutional neural network algorithm were developed in this study. The results showed the capability to distinguish four different gas species and predict their concentrations in real time.
2023 IEEE 36TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, MEMS
(2023)
Article
Urology & Nephrology
Taehee Kim, Ho Seok Chung, Hyun-Suk Lee, Saji Uthaman, In-Kyu Park, Kwangsung Park
Summary: This study aimed to develop HA-based, RA-containing nanomicelles and investigate their effects on regeneration of the vaginal epithelium and AQP3 expression in a murine menopause model. After 4 weeks of treatment, the thickness of the vaginal mucosal epithelial layer and AQP3 expression was increased in the HA-C18-RA group compared with the HA-C18 vehicle group.
INVESTIGATIVE AND CLINICAL UROLOGY
(2023)
Meeting Abstract
Cell & Tissue Engineering
Ayeskanta Mohanty, In-Kyu Park
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Amal Babu, In-Kyu Park
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Shameer Pillarisetti, Kang Moo Huh, In-Kyu Park
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Arathy Vasukutty, In-Kyu Park
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Veena Vijayan, In-Kyu Park
TISSUE ENGINEERING PART A
(2022)
