Targeted prodrugs in oral drug delivery: the modern molecular biopharmaceutical approach

Prodrugs of Acyclovir - A Computational Approach

(2012) Rafik Karaman et al.   Chemical Biology & Drug Design

Mechanisms of Membrane Transport of Folates into Cells and Across Epithelia

(2011) Rongbao Zhao et al.   Annual Review of Nutrition

The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport

(2011) David T Thwaites et al.   BRITISH JOURNAL OF PHARMACOLOGY

Computational-Aided Design for Dopamine Prodrugs Based on Novel Chemical Approach

(2011) Rafik Karaman   Chemical Biology & Drug Design

Targeting Intestinal Transporters for Optimizing Oral Drug Absorption

(2011) Manthena V. Varma et al.   CURRENT DRUG METABOLISM

Effect of Dose Escalation on the In Vivo Oral Absorption and Disposition of Glycylsarcosine in Wild-Type and Pept1 Knockout Mice

(2011) D. Jappar et al.   DRUG METABOLISM AND DISPOSITION

Mechanistic enhancement of the intestinal absorption of drugs containing the polar guanidino functionality

(2011) Jing Sun et al.   Expert Opinion on Drug Metabolism & Toxicology

Computer-assisted design for paracetamol masking bitter taste prodrugs

(2011) Hatem Hejaz et al.   JOURNAL OF MOLECULAR MODELING

Enhancing the Intestinal Membrane Permeability of Zanamivir: A Carrier Mediated Prodrug Approach

(2011) Sheeba Varghese Gupta et al.   MOLECULAR PHARMACEUTICS

Potential of Amino Acid/Dipeptide Monoester Prodrugs of Floxuridine in Facilitating Enhanced Delivery of Active Drug to Interior Sites of Tumors: A Two-Tier Monolayer In Vitro Study

(2011) Yasuhiro Tsume et al.   PHARMACEUTICAL RESEARCH

Prodrugs--from Serendipity to Rational Design

(2011) K. M. Huttunen et al.   PHARMACOLOGICAL REVIEWS

Analyzing the efficiency in intramolecular amide hydrolysis of Kirby’s N-alkylmaleamic acids – A computational approach

(2011) Rafik Karaman   Computational and Theoretical Chemistry

Research Article: Computer-Assisted Design of Pro-drugs for Antimalarial Atovaquone

(2010) Rafik Karaman et al.   Chemical Biology & Drug Design

Prodrugs: Some Thoughts and Current Issues

(2010) Valentino J. Stella   JOURNAL OF PHARMACEUTICAL SCIENCES

Synthesis and In Vitro Evaluation of Gabapentin Prodrugs that Target the Human Apical Sodium-Dependent Bile Acid Transporter (hASBT)

(2010) Rana Rais et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Specificity of a Prodrug-Activating Enzyme hVACVase: The Leaving Group Effect

(2010) Jing Sun et al.   MOLECULAR PHARMACEUTICS

Enabling the Intestinal Absorption of Highly Polar Antiviral Agents: Ion-Pair Facilitated Membrane Permeation of Zanamivir Heptyl Ester and Guanidino Oseltamivir

(2010) Jonathan M. Miller et al.   MOLECULAR PHARMACEUTICS

High-Permeability Criterion for BCS Classification: Segmental/pH Dependent Permeability Considerations

(2010) Arik Dahan et al.   MOLECULAR PHARMACEUTICS

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

The efficiency of proton transfer in Kirby’s enzyme model, a computational approach

(2010) Rafik Karaman   TETRAHEDRON LETTERS

Prediction of Solubility and Permeability Class Membership: Provisional BCS Classification of the World’s Top Oral Drugs

(2009) Arik Dahan et al.   AAPS Journal

Prodrugs: bridging pharmacodynamic/pharmacokinetic gaps

(2009) Bernard Testa   CURRENT OPINION IN CHEMICAL BIOLOGY

The First Bioreversible Prodrug of Metformin with Improved Lipophilicity and Enhanced Intestinal Absorption

(2009) Kristiina M. Huttunen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enhancing the Intestinal Absorption of Molecules Containing the Polar Guanidino Functionality: A Double-Targeted Prodrug Approach

(2009) Jing Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cleavage of Menger’s aliphatic amide: A model for peptidase enzyme solely explained by proximity orientation in intramolecular proton transfer

(2009) Rafik Karaman   JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM

Chemical and Enzymatic Stability of Amino Acid Prodrugs Containing Methoxy, Ethoxy and Propylene Glycol Linkers

(2009) Deepak Gupta et al.   MOLECULAR PHARMACEUTICS

Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs

(2009) Sarah Shugarts et al.   PHARMACEUTICAL RESEARCH

Molecular Basis of Prodrug Activation by Human Valacyclovirase, an α-Amino Acid Ester Hydrolase

(2008) Longsheng Lai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical Pharmacokinetics of XP13512, a Novel Transported Prodrug of Gabapentin

(2008) Kenneth C. Cundy et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Peptide Derivation of Poorly Absorbable Drug Allows Intestinal Absorption Via Peptide Transporter

(2008) Akihiro Kikuchi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Pharmaceutical and pharmacological importance of peptide transporters

(2008) Matthias Brandsch et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Enhanced Cancer Cell Growth Inhibition by Dipeptide Prodrugs of Floxuridine: Increased Transporter Affinity and Metabolic Stability

(2008) Yasuhiro Tsume et al.   MOLECULAR PHARMACEUTICS

Prodrugs: design and clinical applications

(2008) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY

Analysis of Menger’s ‘spatiotemporal hypothesis’

(2008) Rafik Karaman   TETRAHEDRON LETTERS

The oral absorption of phospholipid prodrugs: In vivo and in vitro mechanistic investigation of trafficking of a lecithin-valproic acid conjugate following oral administration

(2007) Arik Dahan et al.   JOURNAL OF CONTROLLED RELEASE

Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting

(2007) Fujun Li et al.   JOURNAL OF PHARMACEUTICAL SCIENCES