Article
Immunology
Joy Bindroo, Khushbu Priyamvada, Lloyd A. C. Chapman, Tanmay Mahapatra, Bikas Sinha, Indranath Banerjee, Prabhas Kumar Mishra, Basab Rooj, Kumar Kundan, Nupur Roy, Naresh Kumar Gill, Allen Hightower, Madan Prasad Sharma, Neeraj Dhingra, Caryn Bern, Sridhar Srikantiah
Summary: India has made significant progress in controlling visceral leishmaniasis by shortening the time untreated patients remain infectious. Research shows that the risk of additional cases in villages increases with higher cumulative incidence, and the time-to-next-case decreases with increasing case-load.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jessica Adriana Jesus, Ilza Maria Oliveira Sousa, Thays Nicolli Fragoso da Silva, Aurea Favero Ferreira, Marcia Dalastra Laurenti, Leila Antonangelo, Caroline Silverio Faria, Paulo Cardoso da Costa, Domingos de Carvalho Ferreira, Luiz Felipe Domingues Passero
Summary: Researchers successfully enhanced the activity of ursolic acid by entrapping it in nanostructured lipid carriers, showing leishmanicidal activity superior to conventional drugs. The treatment not only combats leishmaniasis, but also boosts immune response, protects spleen and liver, and normalizes hepatic and renal functions.
Article
Pharmacology & Pharmacy
Srushti Shah, Vandana Patel
Summary: This article discusses the use of colloidal carriers to improve the ocular bioavailability of Ganciclovir (GCV) for the treatment of opportunistic cytomegalovirus (CMV) infection in the posterior ocular system. Various formulation strategies and carriers are employed to increase drug permeability and prolong drug residence time in the eye.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Immunology
Pushkar Dubey, Aritra Das, Khushbu Priyamvada, Joy Bindroo, Tanmay Mahapatra, Prabhas Kumar Mishra, Ankur Kumar, Ana O. Franco, Basab Rooj, Bikas Sinha, Sreya Pradhan, Indranath Banerjee, Manash Kumar, Nasreen Bano, Chandan Kumar, Chandan Prasad, Parna Chakraborty, Rakesh Kumar, Niraj Kumar, Aditya Kumar, Abhishek Kumar Singh, Kumar Kundan, Sunil Babu, Hemant Shah, Morchan Karthick, Nupur Roy, Naresh Kumar Gill, Shweta Dwivedi, Indrajit Chaudhuri, Allen W. Hightower, Lloyd A. C. Chapman, Chandramani Singh, Madan Prasad Sharma, Neeraj Dhingra, Caryn Bern, Sridhar Srikantiah
Summary: India is making progress towards eliminating visceral leishmaniasis as a public health problem, with timely case detection playing a crucial role in reducing infectivity and controlling outbreaks. Active case detection strategies have been shown to significantly reduce time to diagnosis, lower transmission risk, and ensure higher capture rates of confirmed cases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Renata Rocha da Silva, Fernanda de Santana Fontes Vasconcelos, Debora dos Santos Tavares, Priscila Lima dos Santos
Summary: This study conducted a systematic review and meta-analysis to investigate the association between IL-10 single nucleotide polymorphisms (SNPs) and the progression of leishmaniasis. The results showed that IL-10 SNPs were not significantly associated with leishmaniasis progression and were not considered a risk factor.
SCIENTIFIC REPORTS
(2022)
Review
Immunology
Patricia Sampaio Tavares Veras, Maria Borges Rabelo de Santana, Claudia Ida Brodskyn, Deborah Bittencourt Mothe Fraga, Manuela Silva Solca, Juliana Perrone Bezerra De Menezes, Bruna Martins Macedo Leite, Helena Mariana Pitangueira Teixeira
Summary: Leishmaniasis is a widespread group of infectious diseases that significantly impact global health. The causative agents are protozoan parasites that give rise to various clinical manifestations. Visceral leishmaniasis is the most severe form and can be life-threatening if left untreated.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Marco Antonio Cabrera Gonzalez, Ana Alice Maia Goncalves, Jennifer Ottino, Jaqueline Costa Leite, Lucilene Aparecida Resende, Otoni Alves Melo-Junior, Patricia Silveira, Mariana Santos Cardoso, Ricardo Toshio Fujiwara, Lilian Lacerda Bueno, Renato Lima Santos, Tatiane Furtado de Carvalho, Giani Martins Garcia, Paulo Ricardo de Oliveira Paes, Alexsandro Sobreira Galdino, Miguel Angel Chavez-Fumagalli, Marilia Martins Melo, Denise Silveira-Lemos, Olindo Assis Martins-Filho, Walderez Ornelas Dutra, Vanessa Carla Furtado Mosqueira, Rodolfo Cordeiro Giunchetti
Summary: Visceral leishmaniasis (VL) is a fatal disease caused by Leishmania infantum, and dogs are the main reservoirs. A vaccine against canine visceral leishmaniasis (CVL) is important in controlling human and CVL infections by reducing L. infantum infection. This study evaluated the potential of two polymeric nanoformulations loaded with Leishmania amazonensis antigens as a VL vaccine using golden hamsters as a model. The results showed that the vaccines had no adverse reactions and significantly reduced the parasitic load in the liver and spleen. These vaccines may be promising candidates for a VL vaccine.
Review
Immunology
Katiuska Passelli, Oaklyne Billion, Fabienne Tacchini-Cottier
Summary: Leishmania parasites, transmitted by infected sand flies, cause a range of diseases in mammals. Neutrophils are crucial in the defense against these parasites, although some Leishmania species have developed ways to survive within them. Neutrophils also play a role in shaping the skin microenvironment during infection, influencing the adaptive immune response and disease outcome.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Joao Carlos Franca-Silva, Rodolfo Cordeiro Giunchetti, Reysla Maria da Silveira Mariano, George Luiz Lins Machado-Coelho, Luciana de Almeida Silva Teixeira, Ricardo Andrade Barata, Erika Monteiro Michalsky, Marilia Fonseca Rocha, Consuelo Latorre Fortes-Dias, Edelberto Santos Dias
Summary: This study evaluated the impact of canine euthanasia on the incidence of visceral leishmaniasis in humans and canines. The findings showed that screening and culling measures for canines can reduce the incidence of the disease in both humans and canines.
Article
Immunology
Joao Paulo Araujo de Sousa, Julyanne Maria Saraiva de Sousa, Raiza Raianne Luz Rodrigues, Thais Amanda de Lima Nunes, Yasmim Alves Aires Machado, Alexandre Carvalho de Araujo, Ingrid Gracielle Martins da Silva, Karine Brenda Barros-Cordeiro, Sonia Nair Bao, Michel Mualem de Moraes Alves, Francisco Jaime Bezerra Mendonca-Junior, Klinger Antonio da Franca Rodrigues
Summary: Leishmaniasis, one of the most serious Neglected Tropical Diseases (NTDs), requires urgent therapeutic alternatives due to the problems with currently available drugs. This study found that a thiophene derivative, SB-200, showed promising anti-leishmanial activity and low toxicity in mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Santhi John Tharakan, Dincy C. Peter, Rajiv Karthik, Vedantam Rupa, Winsley Rose, Meera Thomas, Malathi Manuel, Priscilla Rupali, Susanne Pulimood, Sitara Swarna Rao Ajjampur
Summary: This study reports on 52 suspected cases of cutaneous and mucosal leishmaniasis in a tertiary care setting in southern India from 2008 to 2018. Of the 12 confirmed cases, seven had mucocutaneous leishmaniasis, two had cutaneous leishmaniasis, and three had post-kala-azar dermal leishmaniasis. The emerging trend of atypical MCL caused by L. donovani variants highlights the importance of a high index of suspicion combined with PCR-based diagnostics for accurate diagnosis of different manifestations of leishmaniasis.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Biochemistry & Molecular Biology
Satya Prakash, Ambak Kumar Rai
Summary: This study discovered the parasiticidal function of retinoic acid (RA) in infected macrophages and its ability to restore cellular cholesterol levels. It also found that RA can interfere with the growth and viability of the parasite by inhibiting sterol 24-C methyltransferase (SMT), leading to a loss of cellular ergosterol.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Public, Environmental & Occupational Health
Megha Raj Banjara, Anand Ballabh Joshi, Vivek Kumar Singh, Murari Lal Das, Chitra Kumar Gurung, Piero Olliaro, Christine Halleux, Greg Matlashewski, Axel Kroeger
Summary: The visceral leishmaniasis elimination program in Nepal is progressing towards consolidation and maintenance phases. However, new VL foci are appearing, requiring the development and testing of innovative community-centered strategies. Early case detection combined with sandfly control through indoor residual spraying (IRS) or insecticidal wall painting (IWP) has shown efficacy and cost-effectiveness in new and low-endemic districts of Palpa and Surkhet.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Veterinary Sciences
Lucy A. Parker, Lucrecia Acosta, Mariana Noel Gutierrez, Israel Cruz, Javier Nieto, Enrique Jorge Deschutter, Fernando Jorge Bornay-Llinares
Summary: The study utilized city land registry for random selection of domestic dog samples and compared with shelter dogs, showing a higher prevalence among shelter dogs. The seroprevalence among domestic dogs was significantly lower than among the abandoned dogs and the spatial distribution of infected dogs was fairly homogenous throughout the city.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Public, Environmental & Occupational Health
Flavia Chechi, Paola Corsi, Dario Bartolozzi, Giovanni Gaiera, Alessandro Bartoloni, Lorenzo Zammarchi
Summary: The management of visceral leishmaniasis in HIV-infected patients is complex, but intravenous pentamidine rescue treatment can be effective for patients with active chronic VL.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Review
Pharmacology & Pharmacy
Swati Gupta, Pankaj Kumar, Manish K. Gupta, Suresh P. Vyas
CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS
(2012)
Article
Nanoscience & Nanotechnology
Sheeshpal Sharma, Pankaj Kumar, Anil Jaiswal, Anuradha Dube, Swati Gupta
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2011)
Article
Nanoscience & Nanotechnology
Sahil Aggarwal, Sachin Yadav, Swati Gupta
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2011)
Article
Biochemistry & Molecular Biology
Ajay Pal, Swati Gupta, Anil Jaiswal, Anuradha Dube, Suresh P. Vyas
JOURNAL OF LIPOSOME RESEARCH
(2012)
Article
Biotechnology & Applied Microbiology
Sachin Yadav, Swati Gupta
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2015)
Article
Biotechnology & Applied Microbiology
Swati Gupta, Yashwant Pathak, Manish K. Gupta, Suresh P. Vyas
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2019)
Review
Plant Sciences
Manish K. Gupta, Sangram K. Lenka, Swati Gupta, Ravindra K. Rawal
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2020)
Review
Pharmacology & Pharmacy
Ritu Mishra, Swati Gupta
Summary: Rheumatoid arthritis is an autoimmune disease with specific clinical manifestations, influenced by genetic, environmental, and immune factors. While current therapy has limitations, novel drug delivery systems offer potential breakthroughs to enhance the treatment efficacy in the future.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Pharmacology & Pharmacy
Rahul Hasija, Sundeep Chaurasia, Swati Gupta
Summary: The study successfully formulated and optimized colloidal polymeric nanocarriers co-encapsulating resveratrol and humic acid to improve stability, oral bioavailability, and antiradical activity. The optimized nanocarriers demonstrated significant improvement in oral bioavailability and enhanced radical-scavenging activity over time. Developed nanocarriers proved to be an efficient dosage form for enhancing the properties of resveratrol.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2021)
Review
Nanoscience & Nanotechnology
Swati Gupta, Manish K. Gupta
NANO REVIEWS & EXPERIMENTS
(2017)
Article
Pharmacology & Pharmacy
SP Vyas, S Quraishi, S Gupta, KS Jaganathan
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2005)
Article
Pharmacology & Pharmacy
Swati Gupta, Suresh P. Vyas
JOURNAL OF DRUG TARGETING
(2007)
Article
Pharmacology & Pharmacy
Swati Gupta, Anuradha Dube, Suresh P. Vyas
JOURNAL OF DRUG TARGETING
(2007)
Review
Nanoscience & Nanotechnology
Suresh P. Vyas, Swati Gupta
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2006)