期刊
EXPERT OPINION ON BIOLOGICAL THERAPY
卷 8, 期 6, 页码 779-790出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.8.6.779
关键词
Birt-Hogg-Dube; fumarate hydratase; hereditary leiomyomatosis renal cell carcinoma; hereditary papillary renal cancer; kidney cancer; Met; renal cell carcinoma; Von Hippel-Lindau
资金
- Intramural NIH HHS [Z01 SC006659-25] Funding Source: Medline
Background: Kidney cancer is not a homogenous entity; it is comprised of many different tumor types, with different biologies and molecular mechanisms leading to disease and therefore different treatment approaches. Objective: To describe the genetic basis and biochemical pathways underlying inherited forms of renal cancer, specifically in four described syndromes (von Hippel-Lindau [VHL], hereditary papillary renal cancer [HPRC], Birt-Hogg-Dube [BHD] and hereditary leiomyomatosis renal cell carcinoma [HLRCC]), and to elucidate how the understanding of these diseases enables the possibility of disease-specific approaches to therapy. Methods: A systematic review of the published literature on inherited and sporadic forms of renal cancer was performed. Conclusion: Understanding of the biology and mechanisms of different forms of kidney cancer provides an opportunity for development of new treatment options.
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