Article
Endocrinology & Metabolism
Angela Cristina Nicola, Larissa Brazoloto Ferreira, Milene Mantovani Mata, Tatiane Vilhena-Franco, Cristiane Mota Leite, Andressa Busetti Martins, Jose Antunes-Rodrigues, Maristela Oliveira Poletini, Rita Cassia Menegati Dornelles
Summary: During early embryonic development, there are complex interactions and changes in gene expression to adapt to the needs of different stages of embryonic development.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Cynthia N. Ikeji, Isaac A. Adedara, Ebenezer O. Farombi
Summary: This study investigated the impact of myricetin on atrazine-induced reproductive dysfunction and found that myricetin can alleviate the effects of atrazine on the reproductive axis through anti-inflammatory and antioxidant mechanisms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Clinical Neurology
Dimin Zhu, Zheng Xiao, Zongming Wang, Bin Hu, Chengbin Duan, Ziyan Zhu, Nailin Gao, Yonghong Zhu, Haijun Wang
Summary: MEG3 and MIR-3768-3P expression levels were found to be decreased in patients with CNFPA, and their excessive expression inhibited tumorigenesis and promoted apoptosis in PDFS cells. MEG3 acted as an enhancer of MIR-3768-3P expression, while HMGA2 served as an oncogene in pituitary adenoma that could be negatively regulated by MEG3 via enriching MIR-3768-3P, revealing a novel regulatory network in CNFPAs.
JOURNAL OF NEUROSURGERY
(2021)
Article
Biochemistry & Molecular Biology
Shih-Min Hsia, Yi-Fen Chiang, Hsin-Yuan Chen, Mohamed Ali, Paulus S. Wang, Kai-Lee Wang
Summary: The study found that a high-fructose diet can lead to decreased plasma testosterone levels in rats, affecting the responsiveness of Leydig cells to hormones and the activity of the hypothalamus-pituitary-gonadal (HPG) axis.
Article
Environmental Sciences
Dongmei Guo, Wenping Liu, Tingshan Yao, Mengmeng Ma, Qiang Wang, Jing Qiu, Yongzhong Qian
Summary: The study found that Cypermethrin and malathion can disrupt hormonal balance, and their combination can significantly enhance estrogenic effects.
Article
Environmental Sciences
Satabdi Ganguly, Anupam Adhikari, Debalina Sadhukhan, Subhashree Subhasmita Raut, V. Santhana Kumar, Subir Kumar Nag, Basanta Kumar Das
Summary: This study revealed the molecular mechanisms underlying endocrine disruption and reproductive toxicity of cypermethrin in fish exposed to environmentally relevant concentrations. It was found that cypermethrin can affect the sex hormone levels and gene expression in the reproductive system of fish, leading to reduced reproductive potential and recruitment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Pharmacology & Pharmacy
Yuting Zhuang, Tingting Li, Hongwen Xiao, Jiaxu Wu, Shuang Su, Xue Dong, Xiaoxi Hu, Qi Hua, Junwu Liu, Wendi Shang, Jiaming Ju, Fei Sun, Zhenwei Pan, Yanjie Lu, Mingyu Zhang
Summary: The study revealed that the long noncoding RNA H19 plays a pro-senescence role in cardiomyocytes by targeting the miR-19a/SOCS1/p53/p21 pathway. This provides a novel theoretical basis for finding new therapeutic targets for senescence-associated cardiac diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
You Lee Son, Takayoshi Ubuka, Kazuyoshi Tsutsui
Summary: Under stressful conditions, the GnIH neuropeptide may play a key role in regulating reproductive function. Different types and durations of stress can modulate the GnIH system, impacting the activity of the HPG axis. GnIH appears to be a potential novel mediator responsible for stress-induced reproductive dysfunction.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Fisheries
Jiamin Pi, Huan Zhong, Yi Zhou, Tao Dai, Weiling Qin, Hui Liu, Yi Zhang, Yuling Zhou
Summary: This study aimed to investigate the regulatory role of ghrelin on ovarian development in grass carp and its mechanism on key hormonal receptors. The results showed high expression of ghrelin and ghrelin O-acyltransferase in the ovary, and stimulation of folliclestimulating hormone receptor expression by ghrelin treatment. Furthermore, acyl-ghrelin inhibited estrogen receptor-alpha expression, while octanoic acid treatment inhibited ER beta 1 and ER beta 2 expression in the ovary.
AQUACULTURE REPORTS
(2023)
Article
Pharmacology & Pharmacy
G. S. Souza, I. M. M. Freitas, J. C. Souza, S. M. Miraglia, C. C. Paccola
Summary: Smoking can cause various diseases and reduce fertility in both men and women. Nicotine, a harmful component of cigarettes, can reduce placental blood flow and adversely affect the neurological, reproductive, and endocrine development of the baby. This study aimed to evaluate the effects of nicotine on the pituitary-gonadal axis in rats exposed during pregnancy and breastfeeding, and whether these effects would be observed in subsequent generations. The results showed that prenatal exposure to nicotine resulted in structural alterations in the pituitary-gonadal axis in both the first and second generations.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
Chang Shan, Jiang Yue, Wei Liu
Summary: Bones are now seen as an important endocrine organ, with osteocalcin playing a crucial role in influencing insulin secretion, glucose and lipid metabolism, testosterone biosynthesis, and male fertility. However, the detailed functional mechanisms of osteocalcin on the hypothalamic-pituitary-gonadal axis or the pancreas-bone-gonadal axis are not fully understood.
JOURNAL OF ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ozlem Atli Eklioglu, Sinem Ilgin
Summary: The HPG axis plays a crucial role in male reproductive function, with neurotransmitters regulating the release of GnRH by affecting GnRH-releasing neurons. Patients with epilepsy often experience decreased fertility potential and lower sperm quality, which may be related to the impact of antiepileptic drugs on the HPG axis. Antiepileptic drugs can act as endocrine-disrupting chemicals, affecting fertility and exacerbating adverse effects on sperm quality in individuals with epilepsy. Investigating the reproductive effects of antiepileptic drugs and understanding the role of the HPG axis in potential reproductive pathologies is essential.
Article
Biology
Dan Liu, Zhongxiang Tang, Ousman Bajinka, Pei Dai, Guojun Wu, Ling Qin, Yurong Tan
Summary: This study analyzed the differentially expressed miRNAs in RSV-infected patients, asthma patients, and COPD patients through miRNA profiling and integrated analysis. The downregulation of miR-34b/c-5p was observed, and its role in airway inflammation and AHR was confirmed through in vivo and in vitro experiments. The study provides new insights into the molecular mechanism of hsa-miR-34b/c-5p/CXCL10 in airway inflammation and AHR.
Article
Biochemistry & Molecular Biology
Zekai Huang, Markus Kaller, Heiko Hermeking
Summary: miR-34a and miR-34b/c, as direct targets of p53, play a crucial role in the tumor suppressive effects of p53. Inactivating miR-34a and/or miR-34b/c in colorectal cancer cell line HCT116 had significant effects on proliferation, migration, invasion, chemosensitivity, autophagy, and apoptosis. The concomitant deletion of miR-34a and miR-34b/c resulted in EMT signature enrichment, impaired gene repression by the p53-DREAM pathway, and elevated autophagy. A gene signature upregulated in cells with combined inactivation of miR-34a and miR-34b/c was associated with invasive colon cancer subtype CMS4, poor overall survival in CRC patients, and 5-FU resistance in CRC cell lines.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dong Liu, Wenzhi Lv, Weiyin Vivian Liu, Tian Tian, Yuanyuan Qin, Yakun Li, Qin Liu, Jianjian Cai, Sikang Gao, Guojun Ding, Yunyun Zhao, Yiran Zhou, Yan Xie, Wenzhen Zhu
Summary: A noninvasive method using MRI radiomics model was explored to evaluate HPG axis activation in children, providing valuable information in assessing the onset of physiological or pathological puberty. The radiomics model based on CUBE T1WI showed good performance in assessing HPG axis activation.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Obstetrics & Gynecology
Nooshin Salmany, Hajie Lotfi, Rana Keyhanmanesh, Rafighe Ghiasi
Summary: Assisted reproductive technologies (ART) are widely used in infertility treatment, but there is growing interest in alternative approaches such as non-biotechnology, probiotics, and traditional medicinal plants. Nanotechnology has shown great potential in diagnosis, treatment, and drug delivery for reproductive issues. Research on the role of the microbiome in infertility and the benefits of probiotics in various diseases is crucial.
CURRENT WOMENS HEALTH REVIEWS
(2023)
Review
Endocrinology & Metabolism
Fatemeh Abedini, Fariba Giassi, Reza Rahbarghazi, Golamreza Hamidian, Rana Keyhanmanesh
Summary: Diabetes is a major cause of infertility, affecting the quality of life for couples. Reproductive complications due to diabetes are important to clinicians, but treatment options are limited and expensive. Stem cell transplantation has shown promise as a therapeutic option for diabetes-induced infertility. This review examines the current understanding of the role of stem cell transplantation in reproductive complications of diabetes.
CURRENT DIABETES REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Farhad Alizadeh, Fariba Mirzaie Bavil, Rana Keyhanmanesh, Hajie Lotfi, Fariba Ghiasi
Summary: This study investigated the association of pro-inflammatory markers and inflammatory proteins with atherosclerosis index in normal-weight and obese male subjects. The results showed that obese subjects had higher levels of IL-10, IL-1β, CRP, COX-2, TG, and cholesterol, and lower levels of HDL, ApoA1, and ABCA1 compared to normal-weight individuals. Homocysteine levels were high in obese men and had significant correlations with inflammation proteins and markers.
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
(2023)
Article
Cell Biology
Arshad Ghaffari-Nasab, Fariba Ghiasi, Rana Keyhanmanesh, Leila Roshangar, Elnaz Salmani Korjan, Navid Nazarpoor, Fariba Mirzaei Bavil
Summary: This study evaluated the therapeutic effect of c-kit positive cells derived from rat bone marrow on diabetic nephropathy. It was found that the administration of c-kit positive cells could reduce renal fibrosis, attenuate inflammation and restore the expression levels of PI3K/AKT/GSK-3β pathway. Additionally, c-kit positive cells decreased renal apoptosis. These findings suggest that c-kit positive cells could be used as an alternative cell source for treating diabetic nephropathy.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Endocrinology & Metabolism
Keyvan Mehri, Gholamreza Hamidian, Zohreh Zavvari Oskuye, Sepehr Nayebirad, Fereshteh Farajdokht
Summary: Lifestyle changes have led to metabolic disorders becoming a major threat to life. Evidence shows that obesity and diabetes disrupt the reproductive system through their effects on gonads and the hypothalamus-pituitary-gonadal (HPG) axis. Apelin, an adipocytokine, and its receptor (APJ) are involved in the control of reproductive function and also affect food intake, insulin sensitivity, fluid homeostasis, and glucose and lipid metabolisms. This review highlights the physiological effects of the apelinergic system, the relationship between apelin and metabolic disorders, and the impact of apelin on the reproductive system in both genders. The apelin-APJ system may serve as a potential therapeutic target for managing obesity-associated metabolic dysfunction and reproductive disorders.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Hospitality, Leisure, Sport & Tourism
Saber Niazi, Seyed Morteza Tayebi, Pablo B. Costa, Shadmehr Mirdar, Gholamreza Hamidian
Summary: The study found that high-intensity interval training (HIIT) can improve athletic performance, increase HIF-1 alpha level, and raise the rate of apoptosis in the lung and pulmonary duct.
ANNALS OF APPLIED SPORT SCIENCE
(2023)
Article
Endocrinology & Metabolism
Nasim Azizi, Afshin Rahbarghazi, Fariba Mirzaei Bavil, Reza Rahbarghazi, Arshad Ghaffari-Nasab, Jafar Rezaie, Aref Delkhosh, Mahdi Ahmadi
Summary: This study found that diabetes has detrimental effects on lung tissue, and swimming exercise can alleviate these effects. Swimming exercise can reduce diabetic-related pathologies in mouse lungs by regulating apoptosis and inflammatory response.
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2023)
Article
Behavioral Sciences
Saber Ghaderpour, Rana Keyhanmanesh, Gholamreza Hamidian, Hamed Heydari, Fariba Ghiasi
Summary: This study aimed to investigate the beneficial effects of voluntary exercise on sciatic tissue, nitric oxide levels, stereological changes, and peripheral neuropathy caused by high-fat-diet-induced type 2 diabetes mellitus in male rats. Rats were divided into four groups: healthy control, voluntary exercise, diabetic, and diabetic rats treated with voluntary exercise. Voluntary exercise improved thermal and mechanical sensitivity in diabetic rats and also improved the damaged sciatic nerve. Serum nitric oxide levels and histological analyses were conducted to assess the impacts of exercise on the experimental groups.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Fereshteh Nazari-Khanamiri, Nima Abdyazdani, Reza Abbasi, Mahdi Ahmadi, Jafar Rezaie
Summary: Exosomes are membrane-bound nanoparticles that originated from eukaryotic cells and contribute to intracellular communication. Noncoding RNAs carried by exosomes play important roles in tumor angiogenesis, with some promoting tumor progression and others inhibiting angiogenesis. Understanding the roles of exosomal noncoding RNAs can aid in the development of exosome-based cancer therapies and biomarkers.
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Article
Veterinary Sciences
Leila Ahmadzadeh-Gavahan, Ali Hosseinkhani, Gholamreza Hamidian, Seyedhosein Jarolmasjed, Reza Yousefi-Tabrizi
Summary: This study evaluated the effect of restricted nutrition and supplementation of additives on lamb's muscle fibre characteristics. The results showed that neither maternal feed restriction nor the administration of additives had a significant effect on muscle properties of the resulting offspring. Therefore, maternal nutrition may not be a concern in sheep production in arid and semi-arid regions.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Veterinary Sciences
Katayoon Nofouzi, Najmeh Sheikhzadeh, Gholamreza Hamidian, Amir Ali Shahbazfar, Amin Marandi
Summary: This study evaluated the protective effects of Escherichia coli strain Nissle 1917 (EcN) against arsenic (As) exposure in goldfish. The results showed that the supplemented EcN could mitigate the damages caused by As to the organs of fish, indicating its potential to alleviate organ toxicity.
VETERINARY RESEARCH FORUM
(2023)
Article
Veterinary Sciences
Arman Shokri, Reza Asadpour, Razi Jafari-Joozani, Esmaeil Babaei, Abolfazl Hajibemani, Gholamreza Hamidian
Summary: The study aimed to identify differentially expressed plasma miRNAs in cows with clinical and subclinical endometritis. The expression levels of miR-146a and miR-223 were significantly higher and lower, respectively, in cows with clinical and subclinical endometritis compared to healthy cows. The expression levels of miR-146a and miR-223 were significantly higher in the clinical endometritis group. These results suggest that the expression levels of plasma miRNAs can be used as reliable markers to distinguish between subclinical endometritis, clinical endometritis, and healthy cows.
VETERINARY RESEARCH FORUM
(2023)
Article
Pharmacology & Pharmacy
Mohammad Ghader Bayazidi, Reza Rahbarghazi, Aysa Rezabakhsh, Jafar Rezaie, Mehdi Hassanpour, Mahdi Ahmadi
Summary: This study investigated the impact of type 2 diabetes mellitus on autophagy status in rat pulmonary tissue. The results showed that diabetes led to pathological changes in the lungs, accompanied by increased levels of TNF-alpha and TGF-beta. It also disrupted the oxidative status and inhibited the normal activity of autophagy flux.
