Article
Endocrinology & Metabolism
Alicia White, Jane Stremming, Brit H. Boehmer, Eileen I. Chang, Sonnet S. Jonker, Stephanie R. Wesolowski, Laura D. Brown, Paul. J. Rozance
Summary: After a 1-week infusion of IGF-1 LR3, late gestation fetal sheep showed lower plasma insulin and glucose concentrations, reduced fetal glucose-stimulated insulin secretion, and decreased fractional insulin secretion from isolated fetal islets without changes in pancreatic insulin content.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Endocrinology & Metabolism
Kent Pedersen, Helle Andersen, Christian Fledelius, Jens Juul Holst, Sara Toftegaard Hjuler, Rune Ehrenreich Kuhre
Summary: This study investigated the impact of blood sampling methods on glucose regulation and hormone secretion in conscious rats. It was found that restraint and sublingual vein puncture induced stress responses, resulting in reduced glucose absorption, tolerance, and secretion of insulin and glucose-dependent insulinotropic peptide (GIP). These findings suggest the importance of careful selection of blood sampling methods in rat experiments to avoid stress-related biases in the results.
MOLECULAR METABOLISM
(2023)
Article
Endocrinology & Metabolism
Emma J. Buckels, Frank H. Bloomfield, Mark H. Oliver, Ana-Mishel Spiroski, Jane E. Harding, Anne L. Jaquiery
Summary: Fetal growth restriction (FGR) is associated with compromised metabolic function throughout adulthood, but IGF-I therapy in late gestation had long-term sex-specific effects on the endocrine pancreas and skeletal muscle in adult sheep. This study reveals the impact of FGR IGF-I therapy on metabolically active tissues at both tissue and molecular levels in a sex-specific manner.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Toxicology
Angela J. T. Bosch, Theresa V. Rohm, Shefaa AlAsfoor, Andy J. Y. Low, Lena Keller, Zora Baumann, Neena Parayil, Marc Stawiski, Leila Rachid, Thomas Dervos, Sandra Mitrovic, Daniel T. Meier, Claudia Cavelti-Weder
Summary: Air pollution has been found to be a potential risk factor for diabetes, but the mechanism remains unclear. In this study, the researchers investigated the effects on metabolic function of exposure to air pollution particles in both the lung and the gut, and found that exposure in the gut specifically impaired the function of β-cells responsible for insulin secretion.
PARTICLE AND FIBRE TOXICOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Mark H. Oliver, Frank H. Bloomfield, Amita Bansal, Hui Hui Phua, Eric B. Thorstensen, Jane E. Harding, Anne L. Jaquiery
Summary: Maternal periconceptional undernutrition affects fetal pancreatic maturation and glucose tolerance in offspring, with reduced insulin secretion and increased glucose area under the curve in adult sheep. These lasting effects indicate a significant impact of maternal periconceptional nutrition on offspring metabolic homeostasis.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2021)
Article
Public, Environmental & Occupational Health
Alicia White, Jane Stremming, Laura D. Brown, Paul J. Rozance
Summary: Insulin-like growth factor-1 (IGF-1) has been proposed as a therapy for intrauterine growth restriction, but its effects on fetal insulin secretion are not fully understood. In this study, we investigated the short-term effects of IGF-1 infusion on insulin secretion in fetal sheep. We found that IGF-1 reduced fetal plasma insulin concentrations and impaired glucose-stimulated insulin secretion. However, we also observed that isolated fetal islets retained the ability to recover insulin secretion after IGF-1 infusion. These findings suggest that acute IGF-1 infusion may have transient suppressive effects on insulin secretion, but long-term effects need further investigation.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Neurosciences
Kathryn L. Gatford, David J. Kennaway, Hong Liu, David O. Kleemann, Timothy R. Kuchel, Tamara J. Varcoe
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Agriculture, Dairy & Animal Science
Tamara J. Varcoe, Jack R. T. Darby, Kathryn L. Gatford, Stacey L. Holman, Pearl Cheung, Mary J. Berry, Michael D. Wiese, Janna L. Morrison
Article
Reproductive Biology
Jack R. T. Darby, Tamara J. Varcoe, Sandra Orgeig, Janna L. Morrison
Review
Public, Environmental & Occupational Health
Prabha H. Andraweera, Kathryn L. Gatford, Alison S. Care, Tina Bianco-Miotto, Zohra S. Lassi, Gus A. Dekker, Margaret Arstall, Claire T. Roberts
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2020)
Review
Endocrinology & Metabolism
David J. Kennaway
JOURNAL OF PINEAL RESEARCH
(2020)
Article
Endocrinology & Metabolism
Dale McAninch, Tina Bianco-Miotto, Kathy L. Gatford, Shalem Y. Leemaqz, Prabha H. Andraweera, Amy Garrett, Michelle D. Plummer, Gus A. Dekker, Claire T. Roberts, Lisa G. Smithers, Jessica A. Grieger
Article
Neurosciences
Kathryn L. Gatford, David J. Kennaway, Hong Liu, Christopher G. Schultz, Amy L. Wooldridge, Timothy R. Kuchel, Tamara J. Varcoe
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Developmental Biology
Grace M. McBride, Michael D. Wiese, Jia Yin Soo, Jack R. T. Darby, Mary J. Berry, Tamara J. Varcoe, Janna L. Morrison
Article
Pharmacology & Pharmacy
Grace M. McBride, Jia Yin Soo, Tamara Varcoe, Janna L. Morrison, Michael D. Wiese
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2020)
Article
Gastroenterology & Hepatology
Hui Li, Georgia S. Clarke, Stewart Christie, Sharon R. Ladyman, Stephen J. Kentish, Richard L. Young, Kathryn L. Gatford, Amanda J. Page
Summary: This study shows that gastric vagal afferent signaling is attenuated during pregnancy and is inversely associated with meal size. Growth hormone reduces the mechanosensitivity of gastric vagal afferents, suggesting that increased maternal growth hormone levels may play a role in mediating adaptations in gastric vagal afferent signaling during pregnancy. These findings have significant implications for the peripheral control of food intake during pregnancy.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Editorial Material
Neurosciences
Kathryn L. Gatford
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Review
Endocrinology & Metabolism
Harleen Kaur, Beverly S. Muhlhausler, Claire T. Roberts, Kathryn L. Gatford
Summary: The growth hormone (GH)-insulin-like growth factor (IGF) axis undergoes significant changes during pregnancy, with increased secretion of GH and IGFs leading to maternal metabolic adaptations, enhanced placental function, and fetal growth. Exogenous GH or IGF treatment in animal models of normal and compromised pregnancy also promotes similar effects, suggesting alternative approaches to enhance maternal GH abundance during pregnancy for better maternal and fetal outcomes.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Physiology
T. Sebastian Overduin, Hannah R. Wardill, Richard L. Young, Amanda J. Page, Kathryn L. Gatford
Summary: The study optimized Ussing chamber methodology to measure region-specific active glucose transport in the small intestine of mice and found that jejunal active glucose transport changes during the ovarian cycle, with higher levels at proestrus than estrus. This study provides the first direct evidence of changes in SGLT1-mediated glucose transport in the jejunum across the ovarian cycle.
EXPERIMENTAL PHYSIOLOGY
(2023)
Article
Physiology
Tamara J. Varcoe, Jack R. T. Darby, Stacey L. Holman, Emma L. Bradshaw, Tim Kuchel, Lewis Vaughan, Michael Seed, Michael D. Wiese, Janna L. Morrison
PHYSIOLOGICAL REPORTS
(2020)