Article
Neurosciences
Ever Espino-Gonzalez, Peter G. Tickle, Alan P. Benson, Roger W. P. Kissane, Graham N. Askew, Stuart Egginton, T. Scott Bowen
Summary: This study comprehensively characterized skeletal muscle impairments induced by obese-HFpEF in rats, showing decreased muscle blood flow, fibre atrophy, and contractile dysfunction in locomotor muscles, while the diaphragm phenotype remained preserved. These findings suggest potential mechanisms for exercise intolerance in obese-HFpEF.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Pharmacology & Pharmacy
Chih-Min Liu, Fong-Jhih Lin, Yao-Chang Chen, Yung-Kuo Lin, Yen-Yu Lu, Chao-Shun Chan, Satoshi Higa, Shih-Ann Chen, Yi-Jen Chen
Summary: This study aimed to investigate the arrhythmogenic role of excitation-contraction coupling in the right ventricular outflow tract in chloroquine-induced long QT syndrome. The results showed that sequential infusion of chloroquine and azithromycin triggered ventricular tachycardia, which could be suppressed by NCX inhibitors or MgSO4.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
E. Battey, J. A. Ross, A. Hoang, D. G. S. Wilson, Y. Han, Y. Levy, R. D. Pollock, M. Kalakoutis, J. N. Pugh, G. L. Close, G. M. Ellison-Hughes, N. R. Lazarus, T. Iskratsch, S. D. R. Harridge, J. Ochala, M. J. Stroud
Summary: Regular exercise can slow down the age-related decline in skeletal muscle structure and function, but the underlying mechanisms are not fully understood. This study found that exercise-induced remodeling of myonuclei, characterized by increased levels of lamin A and enhanced nuclear stiffness, may contribute to the beneficial effects of exercise on muscle function.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Pediatrics
Claudia Silva Schindel, Daniele Schiwe, Joao Paulo Heinzmann-Filho, Natalia Evangelista Campos, Paulo Marcio Pitrez, Marcio Vinicius Fagundes Donadio
Summary: This study aimed to evaluate the immediate effect of continuous positive airway pressure (CPAP) on exercise tolerance in children with severe therapy-resistant asthma (STRA). The results suggest that the use of CPAP before physical exercise increases exercise duration in children and adolescents with STRA.
WORLD JOURNAL OF PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Matthew J. Barnes, Dominic Lomiwes, David A. D. Parry, Stephen Mackintosh
Summary: This study developed a model of contusion injury in human participants and investigated the physiological responses to four impact loads. The results showed that a higher impact force of 7.2kg resulted in greater volume of oedema, voluntary force loss, pain, and elevations in creatine kinase than the other loads. The study also found significant correlations between oedema volume, pressure pain threshold, and maximum voluntary contraction force.
Article
Acoustics
Beverly A. Wright, Huanping Dai
Summary: This study found that listeners pay more attention to the total duration of expected sounds rather than their specific temporal structure when detecting faint sounds. This is contrary to predictions of the multiple-look model, but in line with predictions of the matched-window energy-detector model.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2021)
Article
Physiology
Heather M. Bowes, Catriona A. Burdon, Gregory E. Peoples, Sean R. Notley, Nigel A. S. Taylor
Summary: The experiment showed that oxygen consumption of healthy humans scales allometrically with body mass across the entire metabolic range, with the scaling exponent significantly increasing from rest to maximal exercise. Only two scaling exponents (rest and exercise) were needed to produce mass-independent outcomes, hence ratiometric and linear regression analyses are not recommended as scaling methods.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kaitlin M. Love, Linda A. Jahn, Lee M. Hartline, James T. Patrie, Eugene J. Barrett, Zhenqi Liu
Summary: This study found that muscle microvascular insulin responses were mainly predicted by M-value and VO(2)max, while predictors of metabolic insulin resistance did not significantly predict microvascular insulin responses.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Theresa Lebacq, Emma Holmberg, Camille Pedroni, Maud Dujeu, Katia Castetbon
Summary: The study found that in adolescents, sleep duration and morning tiredness are independent factors influencing daily breakfast consumption on weekdays.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Multidisciplinary Sciences
Carlo Ferri Marini, Ario Federici, James S. Skinner, Giovanni Piccoli, Vilberto Stocchi, Luca Zoffoli, Luca Correale, Stefano Dell'Anna, Carlo Alberto Naldini, Matteo Vandoni, Francesco Lucertini
Summary: This study assessed the relationship between %HRR and %<(V) over dot>O2R during SSE and found that the relationship is influenced by the duration of exercise, with %HRR higher than %<(V) over dot>O2R in longer SSEs.
Article
Sport Sciences
Akinori Waki, Lu Chen, Kei Hatano, Takahiro Yunoki
Summary: The study found that pre-exercise static stretching reduces exercise efficiency independent of its negative effect on maximal voluntary contraction (MVC) capacity and electromyographic (EMG) activities of muscles during exercise.
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2022)
Article
Biology
Nathan J. Deming, Jacob L. Anna, Benjamin M. Colon-Bonet, Frank A. Dinenno, Jennifer C. Richards
Summary: The study found that different fluid supplementation methods did not significantly affect indicators such as body weight and plasma osmolality after long-duration hot exercise, but fluids supplemented with carbohydrates significantly reduced cognitive function decline. In addition, compared to exercise in a normal temperature environment, exercise in a hot environment resulted in greater dehydration and cognitive function decline.
JOURNAL OF THERMAL BIOLOGY
(2021)
Review
Environmental Sciences
Romina Bonomini-Gnutzmann, Julio Plaza-Diaz, Carlos Jorquera-Aguilera, Andres Rodriguez-Rodriguez, Fernando Rodriguez-Rodriguez
Summary: This systematic review examines the recent research on the impact of high-intensity and high-duration aerobic exercise on gut microbiota composition in athletes. The findings suggest that endurance exercises may have negative effects on gut microbiota, while endurance exercise could have positive effects.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Physiology
Mikaela L. Frechette, Brendan R. Scott, Ann-Maree Vallence, Summer B. Cook
Summary: This study compared the effects of arm cycling with and without blood flow restriction on heart rate, oxygen consumption, blood lactate, and ratings of perceived exertion. The results showed that high workload arm cycling elicited the greatest physiological responses, while low workload and blood flow restriction conditions did not differ significantly. Therefore, practitioners prescribing arm cycling should focus on increasing exercise intensity rather than adding blood flow restriction.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Pezad Doctor, Preetha Balakrishnan, Chenni Sriram, Sanjeev Aggarwal
Summary: This study aimed to evaluate the relationship between exercise capacity and PVC burden in teenagers, and the results indicated that even with PVC burden, children did not show a decrease in exercise capacity.
PEDIATRIC CARDIOLOGY
(2021)
Article
Neurosciences
Matthew L. Racine, Anne R. Crecelius, Gary J. Luckasen, Dennis G. Larson, Frank A. Dinenno
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Sport Sciences
Ida E. Clark, Anni Vanhatalo, Stephen J. Bailey, Lee J. Wylie, Brett S. Kirby, Brad W. Wilkins, Andrew M. Jones
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2018)
Article
Sport Sciences
Brett S. Kirby, Eric M. Bradley, Brad W. Wilkins
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2019)
Article
Physiology
Ida E. Clark, Anni Vanhatalo, Christopher Thompson, Lee J. Wylie, Stephen J. Bailey, Brett S. Kirby, Brad W. Wilkins, Andrew M. Jones
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2019)
Article
Physiology
Ida E. Clark, Anni Vanhatalo, Christopher Thompson, Charlotte Joseph, Matthew Black, Jamie R. Blackwell, Lee J. Wylie, Rachel Tan, Stephen J. Bailey, Brad W. Wilkins, Brett S. Kirby, Andrew M. Jones
JOURNAL OF APPLIED PHYSIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Brett S. Kirby, Matthew A. Sparks, Eduardo R. Lazarowski, Denise A. Lopez Domowicz, Hongmei Zhu, Timothy J. McMahon
Summary: The study found that Panx1 channels participate in hypoxic vasodilation by regulating hypoxia-sensitive extracellular ATP levels in blood. Mice lacking Panx1 showed attenuated decrease in blood pressure and reduced increase in limb blood flow during hypoxia, along with lower plasma ATP levels. This indicates the important role of Panx1 in vascular responses to hypoxia.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Physiology
Brett S. Kirby, David A. Clark, Eric M. Bradley, Brad W. Wilkins
Summary: The study found that during whole body exercise, the balance between muscle oxygen supply and metabolic demand can elucidate intensity domains, reveal a critical metabolic rate, and predict time to exhaustion. Measurement of muscle oxygen saturation percentage accurately predicts depletion and repletion of work capacity and time to exhaustion, providing a physiological boundary between sustainable and unsustainable exercise intensities.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Physiology
Brett S. Kirby, Brad J. Winn, Brad W. Wilkins, Andrew M. Jones
Summary: The best possible finishing time of a runner in distance track events depends on their critical speed (CS) and the finite energy that can be expended above CS. The interaction between pacing strategies, initial CS, and D' balance predicts final race finishing positions. The D' balance model accurately predicts finishing positions in both slow and fast races, highlighting the impact of pacing strategy on race outcomes.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Sport Sciences
Matthew Black, Sascha H. Kranen, Stefan Kadach, Anni Vanhatalo, Brad Winn, Emily M. Farina, Brett S. Kirby, Andrew M. Jones
Summary: This study aimed to investigate the effects of a highly cushioned running shoe (HCS) on incremental exercise performance and oxygen cost (O-c), as well as its impact on the deterioration of O-c caused by muscle damage from downhill running. The results showed that the HCS improved incremental exercise performance and O-c, and maintained the improved O-c even in the presence of muscle damage.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Letter
Sport Sciences
Ryan M. Broxterman, Jesse C. Craig, Brett S. Kirby
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2022)
Article
Physiology
Philip M. Batterson, Brett S. Kirby, Georg Hasselmann, Andri Feldmann
Summary: Monitoring muscle metabolic activity through blood lactate is useful for understanding the physiological response to exercise intensity, and recent evidence suggests that SmO2 can predict endurance performance outcomes. This study found a strong correlation between SmO2 rate and blood lactate concentration across muscle sites, and the breakpoints in SmO2 rate were consistent with established lactate thresholds.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Physiology
Ian R. Matthews, Logan J. Heenan, Kathleen G. Fisher, Emma F. Flood, Logan W. Wehrman, Brett S. Kirby, Brad W. Wilkins
Summary: This study tested the hypothesis that the slope of muscle oxygen saturation (%SmO2) can differentiate the boundary between heavy-severe exercise domains and the highest steady-state metabolic rate. The results showed that %SmO2 slope can accurately delineate steady state from nonsteady-state metabolic parameters and determine the boundary of the heavy-severe domain, independent of work rate.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Cameron Dickens, Kimberly E. Bigelow, Anne R. Crecelius
Meeting Abstract
Biochemistry & Molecular Biology
Cameron M. Dickens, Anne R. Crecelius
Meeting Abstract
Biochemistry & Molecular Biology
Anne R. Crecelius