Article
Microbiology
Hongli Zhou, Xiaojing Zeng, Dongchen Sun, Zhe Chen, Weixin Chen, Liwei Fan, Yanin Limpanont, Paron Dekumyoy, Wanchai Maleewong, Zhiyue Lv
Summary: This study investigated the therapeutic effects of monosexual Schistosoma japonicum cercariae and dexamethasone on inflammatory bowel disease using a mouse model. The results showed that monosexual Schistosoma japonicum cercariae could alleviate clinical symptoms of inflammatory bowel disease and improve intestinal permeability by modulating the Th1/Th2 balance, Treg cell population, and reshaping the gut microbiota community.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Parasitology
Bikash R. Giri, Chuantao Fang, Guofeng Cheng
Summary: This study identified hundreds of gender-associated circRNAs in the blood fluke Schistosoma japonicum, and suggested their potential regulatory roles in gene expression through binding with microRNAs.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2022)
Review
Immunology
Kaijuan Wu, Xingyu Zhai, Shuaiqin Huang, Liping Jiang, Zheng Yu, Jing Huang
Summary: Infection by Schistosoma japonicum can lead to serious organ damage and schistosomiasis japonica, with drug resistance being a continual concern. Protein kinases play essential roles in the growth and development of S. japonicum and interactions with hosts, providing potential drug targets for developing new treatments. The current challenges and problems in studying SjPKs can guide future development of anti-schistosomiasis drugs and vaccines.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Cell Biology
Huijuan Yang, Hongqi Li, Weidong Chen, Zhijie Mei, Yuan Yuan, Xiaoli Wang, Liang Chu, Yu Xu, Yan Sun, Dingru Li, Hongyu Gao, Bin Zhan, Huihui Li, Xiaodi Yang
Summary: The study found that rSj-Cys has significant therapeutic effects on weight gain, hyperlipidemia, and atherosclerosis, improving kidney functions by promoting macrophage polarization and regulating T cell responses. The results suggest that rSj-Cys could be developed as a therapeutic agent for lipid metabolism disorders and atherosclerosis globally.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Veterinary Sciences
Haoran Zhong, Ling Hou, Fanglin Qin, Yuqi Ren, Bowen Dong, Danlin Zhu, Hao Li, Ke Lu, Zhiqiang Fu, Jinming Liu, Shaopeng Gu, Yamei Jin
Summary: This study assessed the expression profiles of ANX A13 protein during the development of Schistosoma japonicum, and demonstrated its crucial role in the development and egg production of female worms. Furthermore, it found that SjANX A13 could enhance the production of specific antibodies and participate in host-parasite interactions through exosomes.
VETERINARY RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Ailei Xu, Guanzhen Zhong, Jiwen Wang, Chong Liu, Yaqian Liu, Wei Wang
Summary: MiR-200a can inhibit the activation and proliferation of hepatic stellate cells through the TGF-beta signaling pathway, improving fibrotic lesions. Upregulation of miR-200a may contribute to inhibiting schistosomiasis liver fibrosis by reducing fibrosis factors and inflammatory cytokines.
Article
Parasitology
Zheng Shang, Qinghong Guo, Xue Zhou, Yongcheng Yue, Kerou Zhou, Liying Tang, Zhizhong Zhang, Zhiqiang Fu, Jinming Liu, Jiaojiao Lin, Bin Xu, Min Zhang, Yang Hong
Summary: The gene encoding SjAAP was found to be expressed in all developmental stages of Schistosoma japonicum, with higher expression in 8, 14, 21, and 28-day-old worms. The recombinant SjAAP showed enzymatic activity and was primarily distributed on the tegument and parenchyma of schistosomes.
Article
Immunology
Hong Xie, Lingqin Wu, Xingzhi Chen, Shifang Gao, Huihui Li, Yuan Yuan, Jinbao Liang, Xiaoli Wang, Shuying Wang, Changyan Xu, Liang Chu, Bin Zhan, Rui Zhou, Xiaodi Yang
Summary: Sj-Cys is a potent immunomodulatory protein that exerts anti-inflammatory effects by activating M2 macrophage polarization. The findings suggest that Sj-Cys itself or Sj-Cys-induced M2 macrophages could be used as therapeutic agents in the treatment of sepsis or other inflammatory diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Nian-Nian Bi, Song Zhao, Jian-Feng Zhang, Ying Cheng, Chen-Yang Zuo, Gang-Long Yang, Kun Yang
Summary: This study used a label-free proteomics method to investigate potential biomarkers for early diagnosis of schistosomiasis. The results revealed significant changes in host-derived proteins and S. japonicum proteins during infection and treatment, suggesting implications for early detection and treatment of the disease. These findings offer new insights into the pathogenesis of S. japonicum and guidance for potential biomarkers for schistosomiasis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Panpan Dong, Congjin Mei, Yingying Yang, Yonghua Zhou, Yongliang Xu, Lijun Song, Chuanxin Yu
Summary: Schistosomiasis is characterized by immunopathological liver fibrosis. B-cell-activating factor (BAFF) plays a role in autoimmune diseases and fibrosis, but its role in schistosomiasis liver fibrosis is unclear. This study found that BAFF level and its receptor BAFF-R increased and then decreased with the progression of S. japonicum infection, which was consistent with hepatic granuloma and fibrosis. Anti-BAFF treatment reduced histopathological damage, granuloma size, and liver fibrosis, while increasing IL-10 and decreasing IL-4, IL-6, IL-17A, TGF-β, and antibody levels against S. japonicum antigens. This suggests that BAFF could be a potential target for treating schistosomiasis liver fibrosis.
Review
Clinical Neurology
Kang Wu, Hong Yu Zhao, Kai Shu, Ting Lei, Liang Zeng
Summary: This report presents a rare case of pseudotumoral form of Schistosoma japonicum in the brainstem, initially misdiagnosed as a malignant tumor. The patient achieved complete remission through appropriate treatment.
FRONTIERS IN NEUROLOGY
(2022)
Review
Parasitology
Cheng Chen, Qinghong Guo, Zhiqiang Fu, Jinming Liu, Jiaojiao Lin, Kai Xiao, Pengxiang Sun, Xiaonan Cong, Runxia Liu, Yang Hong
Summary: Despite a significant decrease in the prevalence and intensity of Schistosoma japonicum infection in China, this disease remains a serious public health concern in certain endemic areas in the Philippines and Indonesia. Therefore, more accurate and sensitive diagnostic methods are crucial for further control of this disease. This review explores the research progress in techniques for diagnosing S. japonicum infection.
Article
Parasitology
Bing Shao, Xiang Gui, Zhenjie Lu, Rongxue Lv, Hao Li, Ke Lu, Yang Hong, Zhiqiang Fu, Yamei Jin, Jiaojiao Lin, Chenzhong Fei, Jinming Liu
Summary: This study found that pretreatment with Praziquantel enhances the resistance of mice against Schistosoma japonicum infection, with a peak effect observed two days after administration and a protection period of at least 18 days. The exact mechanisms of the preventive effect require further investigation.
Article
Multidisciplinary Sciences
Natasha L. Hirst, Scott P. Lawton, Anthony J. Walker
Summary: CaMKII is activated in different stages of Schistosoma mansoni, including nervous tissue, tegument, muscles, and vitellaria. Activation of CaMKII is associated with the response to the anti-schistosomal drug praziquantel and the vitality of the worms. CaMKII interacts with multiple proteins, participates in various signaling pathways, and plays a role in ion transport and voltage-dependent channels in schistosomes.
SCIENTIFIC REPORTS
(2022)
Article
Parasitology
Elise Grover, Sara Paull, Katerina Kechris, Andrea Buchwald, Katherine James, Yang Liu, Elizabeth J. Carlton
Summary: This study investigates the physical and environmental predictors of bovine Schistosoma japonicum infection in rural areas of China using a machine learning approach. The results highlight the importance of factors such as bovine density, agricultural practices, and human infection prevalence in predicting bovine infection.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2022)
