期刊
EXPERIMENTAL PARASITOLOGY
卷 135, 期 2, 页码 456-458出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2013.08.008
关键词
Substituted phenalenones; Antiplasmodial; P. falciparum
类别
资金
- MINECO [SAF 2012-37344-C03-01]
A set of derivatives encompassing structural modifications on the privileged phenalenone scaffold were assessed for their antiplasmodial activities against a strain of chloroquine sensitive Plasmodium falciparum F32. Two compounds exhibited considerable effects against the malaria parasite (IC50 <= 1 mu g/mL), one of which maintained the same level of activity in a chloroquine-resistant strain. This is the first record of antiplasmodial activity on this type of scaffold, providing a new structural motif as a new lead for antimalarial activity. (C) 2013 Elsevier Inc. All rights reserved.
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