Article
Agriculture, Dairy & Animal Science
Fangyuan Yin, Daoe Mu, Zhuojia Tian, Dong Li, Xiting Ma, Jinming Wang, Guiquan Guan, Hong Yin, Facai Li
Summary: Tick-borne diseases in companion animals are increasing globally. This study detected the first case of Babesia gibsoni infection in cats in China. The findings provide important insights into the epidemiology of babesiosis in China and offer a foundation for developing effective disease control measures.
Article
Agriculture, Dairy & Animal Science
Oliwier Teodorowski, Marcin Kalinowski, Dagmara Winiarczyk, Banu Dokuzeylul, Stanislaw Winiarczyk, Lukasz Adaszek
Summary: Canine babesiosis is a tick-borne, hemoparasitic disease caused by protozoal infection by parasites of the genus Babesia. Babesia gibsoni is a small protozoan species with a prevalence of around 1% in infected dogs in Europe. It is more severe than Babesia canis infections and accurate detection and identification are important for proper treatment and disease prediction. It is expected that B. gibsoni infections may appear in other non-endemic regions in Europe in the future, posing challenges for veterinary practitioners.
Article
Virology
Poonsook Keelapang, Chutitorn Ketloy, Chunya Puttikhunt, Rungtawan Sriburi, Eakachai Prompetchara, Malinee Sae-Lim, Bunpote Siridechadilok, Thaneeya Duangchinda, Sansanee Noisakran, Nicha Charoensri, Prapat Suriyaphol, Piyanan Suparattanagool, Utaiwan Utaipat, Promsin Masrinoul, Panisadee Avirutnan, Juthathip Mongkolsapaya, Gavin Screaton, Prasert Auewarakul, Suchinda Malaivijitnond, Sutee Yoksan, Prida Malasit, Kiat Ruxrungtham, Rojjanaporn Pulmanausahakul, Nopporn Sittisombut
Summary: This study investigated the induction of protective antibody responses against dengue virus infection in a non-human primate model using a heterologous prime-boost vaccination approach. The results showed that all macaques had elevated levels of neutralizing antibodies after 1 month of immunization, and the overall protective efficacy against clinical isolates reached 91%.
JOURNAL OF VIROLOGY
(2023)
Article
Parasitology
Shengwei Ji, Mingming Liu, Eloiza May Galon, Mohamed Abdo Rizk, Bumduuren Tuvshintulga, Jixu Li, Iqra Zafar, Yae Hasegawa, Aiko Iguchi, Naoaki Yokoyama, Xuenan Xuan
Summary: This study evaluated the in vitro and in vivo anti-Babesia activity of naphthoquine phosphate (NQP) and found that NQP showed promising therapeutic efficacy against Babesia infections.
PARASITES & VECTORS
(2022)
Article
Agriculture, Dairy & Animal Science
Martina Karasova, Csilla Tothova, Simona Grelova, Maria Fialkovicova
Summary: Babesia gibsoni is a parasite that causes red blood cell rupture in dogs, and its incidence has been increasing in European countries. Fighting dog breeds are more susceptible to the disease and may serve as potential sources of infection. The disease is often asymptomatic and easily introduced into Europe through importation or travel of dogs from endemic areas. This highlights the need for attention and study of B. gibsoni infection and its treatment, which can be challenging.
Article
Veterinary Sciences
Fangyuan Yin, Chuanjiang Guo, Zhuojia Tian, Dong Li, Daoe Mu, Haoting Liu, Guiquan Guan, Hong Yin, Facai Li
Summary: Babesia gibsoni is a tick-borne protozoan causing canine babesiosis. Genetic variation of B. gibsoni population was examined to understand disease transmission and develop control strategies. Results showed high genetic diversity within populations and significant differentiation across continents.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Martina Karasova, Csilla Tothova, Bronislava Vichova, Lucia Blanarova, Terezia Kiskova, Simona Grelova, Radka Staronova, Alena Michal'ova, Martin Kozar, Oskar Nagy, Maria Fialkovicova
Summary: This study evaluates the efficacy and safety of combined treatment with Malarone(R), azithromycin, and artesunate for canine babesiosis caused by Babesia gibsoni. The results demonstrate that the combined treatment successfully eliminates parasitemia in chronically infected dogs with B. gibsoni, and no clinically apparent adverse effects were reported during the treatment.
Article
Microbiology
Qin Liu, Xing-Ai Guan, Dong-Fang Li, Ya-Xin Zheng, Sen Wang, Xue-Nan Xuan, Jun-Long Zhao, Lan He
Summary: In this study, the whole genome of B. gibsoni was sequenced, assembled, and annotated for the first time. The key part of the genome, four chromosomes, was comparatively analyzed. The research provided valuable genetic data to explore new avenues and solve theoretical and practical problems related to babesiosis.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Thom Do, Ruttayaporn Ngasaman, Vannarat Saechan, Opal Pitaksakulrat, Mingming Liu, Xuenan Xuan, Tawin Inpankaew
Summary: The study conducted in southern Thailand revealed a variety of canine vector-borne pathogens in stray dogs, with Hepatozoon canis being the most common infection. Molecular detection and genetic characterization of B. gibsoni were successfully performed for the first time in dogs in Thailand in this study.
Article
Cell Biology
Zixi Yin, Ji-Li Chen, Yongxu Lu, Beibei Wang, Leila Godfrey, Alexander J. Mentzer, Xuan Yao, Guihai Liu, Dannielle Wellington, Yiqi Zhao, Peter A. C. Wing, Wanwisa Dejnirattisa, Piyada Supasa, Chang Liu, Philip Hublitz, Ryan Beveridge, Craig Waugh, Sally-Ann Clark, Kevin Clark, Paul Sopp, Timothy Rostron, Juthathip Mongkolsapaya, Gavin R. Screaton, Graham Ogg, Katie Ewer, Andrew J. Pollard, Sarah Gilbert, Julian C. Knight, Teresa Lambe, Geoffrey L. Smith, Tao Dong, Yanchun Peng
Summary: This study evaluates T cell responses in recovered COVID-19 patients and vaccinated donors using recombinant vaccinia virus (rVACV) expression of SARS-CoV-2 spike protein and SARS-CoV-2 infection of ACE-2-transduced B cell lines. The results show that rVACV expression of SARS-CoV-2 antigen can be used to assess T cell responses to naturally processed spike antigens. The rVACV system can also be used to evaluate cross-reactivity of memory T cells to variants of concern and identify epitope escape mutants.
Article
Immunology
Hewei Zhang, Jingqiang Ren, Jiachen Lid, Chongkai Zhai, Fuchao Mao, Shaozhe Yang, Qingwei Zhang, Zhongyu Liu, Xiuhong Fu
Summary: This study investigated the immunogenicity and protective efficacy of different vaccination regimens for pigs against PRRSV infection. The findings suggest that a heterologous prime-boost vaccine regimen can improve immune responses and provide resistance to PRRSV infection in pigs.
MICROBIAL PATHOGENESIS
(2023)
Article
Parasitology
Hang Li, Shengwei Ji, Eloiza May Galon, Iqra Zafar, Zhuowei Ma, Thom Do, Moaz M. Amer, Yihong Ma, Junya Yamagishi, Mingming Liu, Xuenan Xuan
Summary: This study identified and characterized three members of the CCp family in B. gibsoni. The sexual stages of B. gibsoni were induced in vitro and it was confirmed that the expression of CCp proteins increased significantly. These findings provide important insights for understanding the biology of B. gibsoni and developing transmission-blocking vaccines against canine babesiosis.
Article
Virology
Caroline K. Martin, Jerzy Samolej, Annabel T. Olson, Cosetta Bertoli, Matthew S. Wiebe, Robertus A. M. de Bruin, Jason Mercer
Summary: Modulation of the host cell cycle is a common strategy used by viruses to create a pro-replicative environment. Vaccinia virus (VACV) has been reported to alter cell cycle regulation and trigger the host cell DNA damage response. This study investigates the effect of VACV infection on cell proliferation and host cell cycle progression. It identifies the viral effectors responsible for inhibiting cell proliferation and shifting the host cell cycle, and reveals the involvement of viral kinases in activating the DNA damage checkpoint and mediating the degradation of checkpoint effectors.
Article
Parasitology
Shaza Rahman, Varuna Purushothama Panicker, Athira Narayanan, Usha Narayana Pillai, Madhavan Unny, Gouree Krishna, Nimi Pullenkunnel Simon
Summary: The development and rise of drug resistant Babesia gibsoni strain poses a serious concern among veterinary practitioners. The study focused on mutations induced by buparvaquone in B. gibsoni, with 8 dogs showing unresponsiveness to treatment. Analysis of cytochrome b gene mutations revealed potential implications for treatment strategies.
VETERINARY PARASITOLOGY
(2022)
Article
Parasitology
Jiaying Guo, Furong Yang, Lingna Wang, Xuenan Xuan, Junlong Zhao, Lan He
Summary: This study sequenced the transcriptome of the asexual stages of B. gibsoni for the first time and identified the highly expressed BgP30 gene. Further studies demonstrated that BgP30 can induce immune response in dogs infected with B. gibsoni, suggesting its potential as a good diagnostic candidate marker for both acute and chronic infections.
PARASITES & VECTORS
(2022)
