Article
Immunology
Basudev Paudyal, Adam McNee, Pramila Rijal, B. Veronica Carr, Alejandro Nunez, John McCauley, Rodney S. Daniels, Alain R. Townsend, John A. Hammond, Elma Tchilian
Summary: Prophylactic intravenous administration of specific monoclonal antibodies in pigs showed significant reduction in lung pathology and virus loads, but not consistent reduction in nasal shedding. The effect on lung pathology and virus load is consistent across different doses, suggesting that lower doses may be effective in reducing disease severity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiaojie Yu, Christian M. Orr, H. T. Claude Chan, Sonya James, Christine A. Penfold, Jinny Kim, Tatyana Inzhelevskaya, C. Ian Mockridge, Kerry L. Cox, Jonathan W. Essex, Ivo Tews, Martin J. Glennie, Mark S. Cragg
Summary: Low affinity of immunomodulatory antibodies leads to greater activity through increased clustering, resulting in higher immune cell activation, T cell expansion, and antitumor activity. This discovery reveals a new mechanism for enhancing receptor activation across diverse receptor families and sheds light on the mechanism of antibody-mediated receptor signaling. Affinity engineering offers a rational, efficient, and tunable solution for delivering antibody-mediated receptor activity for the treatment of human disease.
Review
Clinical Neurology
Shayan Ali Irfan, Minha Murtaza, Ali Ahmed, Hina Altaf, Abid Anwar Ali, Naqiha Shabbir, Mirza Mehmood Ali Baig
Summary: Analysis of clinical trials assessing the safety and efficacy of Temelimab in patients with Multiple Sclerosis demonstrates that the drug is safe and effective.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Luigi Pontieri, Morten Blinkenberg, Stephan Bramow, Viktoria Papp, Peter Rasmussen, Matthias Kant, Jakob Schaefer, Henrik K. Mathiesen, Michael B. Jensen, Georgi Sirakov, Jonas M. Berg, Tine Kopp, Hanna Joensen, Finn Sellebjerg, Melinda Magyari
Summary: This study evaluated the real-world effectiveness and safety of ocrelizumab treatment for multiple sclerosis (MS) patients in Denmark. The results showed that most patients experienced clinical stabilization and had a favorable adverse event profile consistent with previous clinical trials. Ocrelizumab was well tolerated with minimal side effects reported in only 10% of patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Medicine, General & Internal
Luca Massacesi, Alice Mariottini, Ferdinando Nicoletti
Summary: Evidence of the effectiveness of B-cell-depleting monoclonal antibodies in multiple sclerosis has led to a re-examination of the pathogenesis of the disease. The mechanisms underlying the efficacy of these antibodies likely involve impairing B-cell functions other than antibody secretion and potentially impacting inflammation within the central nervous system. However, further research is needed to understand these mechanisms and the ability of the antibodies to cross the blood-brain barrier.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Hematology
Xavier Leleu, Thomas Martin, Katja Weisel, Fredrik Schjesvold, Shinsuke Iida, Fabio Malavasi, Salomon Manier, Chang-Ki Min, Enrique M. Ocio, Charlotte Pawlyn, Aurore Perrot, Hang Quach, Joshua Richter, Ivan Spicka, Kwee Yong, Paul G. Richardson
Summary: CD38 is a crucial transmembrane glycoprotein involved in the regulation of calcium signaling and immune cell migration to tumor microenvironments. Targeting CD38 with monoclonal antibodies such as isatuximab and daratumumab has shown promising results in the treatment of multiple myeloma patients. These antibodies possess similarities and differences in their mechanisms of action, and have been shown to induce adaptive immune responses and modulate the bone marrow niche. Further research is needed to determine the optimal selection and sequencing of anti-CD38 antibody therapies in relapsed and/or refractory multiple myeloma.
ANNALS OF HEMATOLOGY
(2022)
Review
Clinical Neurology
Kanika Sharma, Sarah Tolaymat, Hongxuyang Yu, Mahmoud Elkhooly, Shruti Jaiswal, Anek Jena, Mihir Kakara, Shitiz Sriwastava
Summary: Progressive multifocal leukoencephalopathy (PML) is a subacute CNS inflammatory disease primarily seen among immunocompromised patients. It is caused by the JC virus (JCV) and can also be associated with monoclonal antibody immunotherapy.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Hematology
Alex F. Herrera, Joycelynne Palmer, Vikram Adhikarla, Dave Yamauchi, Erasmus K. Poku, James Bading, Paul Yazaki, Savita Dandapani, Matthew Mei, Robert Chen, Thai Cao, Nicole Karras, Pamela McTague, Auayporn Nademanee, Leslie Popplewell, Firoozeh Sahebi, John E. Shively, Jennifer Simpson, D. Lynne Smith, Joo Song, Ricardo Spielberger, Ni-Chun Tsai, Sandra H. Thomas, Stephen J. Forman, David Colcher, Anna M. Wu, Jeffrey Wong, Eileen Smith
Summary: In this study, the addition of 90Y-antiCD25 (aTac) to BEAM AHCT for high-risk relapsed or refractory classical Hodgkin lymphoma (HL) patients was shown to be safe and effective, with favorable outcomes observed in terms of toxicity, engraftment, and overall survival. Further evaluation of this approach in a phase 2 trial is ongoing to assess its efficacy.
Article
Oncology
Thomas G. Martin, Nina Shah, Joshua Richter, David H. Vesole, Sandy W. Wong, Chiung-Yu Huang, Deepu Madduri, Sundar Jagannath, David S. Siegel, Noa Biran, Jeffrey L. Wolf, Samir Parekh, Hearn J. Cho, Pamela Munster, Shambavi Richard, Samira Ziti-Ljajic, Ajai Chari
Summary: This study evaluated the safety and efficacy of Isa and K combination therapy in patients with RRMM. Despite heavily pretreated patients, 70% responded to the treatment, with a median progression-free survival of 10.1 months.
Review
Clinical Neurology
Julia Kraemer, Heinz Wiendl
Summary: The review highlights the importance of safety evaluation, the role of memory B cells in immunopathogenesis, and the relationship between pathophysiology and treatment outcomes when utilizing monoclonal antibodies for the treatment of multiple sclerosis. Understanding these aspects is crucial for optimizing future trial designs and improving therapeutic efficacy.
Article
Biochemistry & Molecular Biology
Nohara Goto, Hiroyuki Suzuki, Tomohiro Tanaka, Teizo Asano, Mika K. Kaneko, Yukinari Kato
Summary: CD44 is a cell surface glycoprotein involved in various cellular functions. The established antibody C(44)Mab-46 is important for cancer diagnosis and therapy by detecting CD44 in different applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Kara M. Gillmann, J. Sebastian Temme, Samantha Marglous, Claire E. Brown, Jeffrey C. Gildersleeve
Summary: Anti-glycan monoclonal antibodies (mAbs) have diverse applications in human health and basic research, including cancer diagnostics and therapeutics. Despite the limited supply of high-quality anti-glycan mAbs, recent advances have been made in targeting cancer- and infectious disease-associated glycans, providing new opportunities for discovery and development of therapeutic antibodies.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ryo Ejima, Hiroyuki Suzuki, Tomohiro Tanaka, Teizo Asano, Mika K. Kaneko, Yukinari Kato
Summary: CD44 is a cell surface glycoprotein with isoforms produced by alternative splicing. CD44 variant exon-containing isoforms (CD44v) are overexpressed in carcinomas, and CD44v6 predicts poor prognosis in colorectal cancer patients. CD44v6 plays important roles in CRC adhesion, proliferation, stemness, invasiveness, and chemoresistance. In this study, anti-CD44 monoclonal antibodies (mAbs) were developed and characterized for detecting CD44v6 in various applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biotechnology & Applied Microbiology
Tereza Gabelic, Barbara Barun, Ivan Adamec, Magdalena Krbot Skoric, Mario Habek
Summary: Traditionally, the management of active relapsing remitting MS involved continuous treatment with disease modifying therapy, while newer approaches include short-term therapy or the use of monoclonal antibodies. The introduction of monoclonal antibodies has revolutionized MS treatment, but the choice of DMT remains a challenge for patients and neurologists.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Zhijue Xu, Zhaoyu Wu, Sheng Huang, Kaichuang Ye, Yihong Jiang, Jianqiang Liu, Junchao Liu, Xinwu Lu, Bo Li
Summary: Immunomodulatory therapy has shown promise in treating cardiovascular diseases, but challenges remain in terms of drug co-delivery and combination therapies. This study developed a multifunctional nanoparticle (RUFI) for treating atherosclerotic cardiovascular disease, which successfully targeted and reduced plaques in mouse models. The study demonstrated the enhanced immunoregulatory effects of combining rapamycin and IL-1Ra through MOF carriers, suggesting potential treatments for atherosclerosis and other inflammatory diseases.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Clinical Neurology
Nikolai Pfender, Michael Linnebank, Michael Sommerauer, Alexander A. Tarnutzer
JOURNAL OF CLINICAL NEUROSCIENCE
(2015)
Editorial Material
Clinical Neurology
Nikolai Pfender, Ilijas Jelcic, Michael Linnebank, Urs Schwarz, Roland Martin
Review
Clinical Neurology
Nikolai Pfender, Riccardo Saccardi, Roland Martin
CURRENT TREATMENT OPTIONS IN NEUROLOGY
(2013)
Letter
Allergy
Silke C. Hofmann, Nikolai Pfender, Steffi Weckesser, Johannes Huss-Marp, Thilo Jakob
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2011)
Article
Allergy
Ulrike Luckey, Talkea Schmidt, Nikolai Pfender, Maike Romer, Nadine Lorenz, Stefan F. Martin, Tobias Bopp, Edgar Schmitt, Alexey Nikolaev, Nir Yogev, Ari Waisman, Thilo Jakob, Kerstin Steinbrink
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2012)
Article
Medicine, General & Internal
Carl Moritz Zipser, Nikolai Pfender, Jose Miguel Spirig, Michael Betz, Jose Aguirre, Markus Hupp, Mazda Farshad, Armin Curt, Martin Schubert
Article
Medicine, General & Internal
Veronika Birkhaeuser, Martina D. Liechti, Collene E. Anderson, Lucas M. Bachmann, Sarah Baumann, Michael Baumberger, Lori A. Birder, Sander M. Botter, Silvan Bueeler, Celia D. Cruz, Gergely David, Patrick Freund, Susanne Friedl, Oliver Gross, Margret Hund-Georgiadis, Knut Husmann, Xavier Jordan, Miriam Koschorke, Lorenz Leitner, Eugenia Luca, Ulrich Mehnert, Sandra Moehr, Freschta Mohammadzada, Katia Monastyrskaya, Nikolai Pfender, Daniel Pohl, Helen Sadri, Andrea M. Sartori, Martin Schubert, Kai Sprengel, Stephanie A. Stalder, Jivko Stoyanov, Cornelia Stress, Aurora Tatu, Cecile Tawadros, Stephanie van der Lely, Jens Woellner, Veronika Zubler, Armin Curt, Juergen Pannek, Martin W. G. Brinkhof, Thomas M. Kessler
Article
Allergy
T. Jakob, N. Pfender, T. Koenig, S. Kunz, S. F. Martin
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)