Article
Behavioral Sciences
Wen-Rui Gao, Xiao-Hong Hu, Kai-Yue Yu, Hong-Yan Cai, Zhao-Jun Wang, Lei Wang, Mei-Na Wu
Summary: Cognitive dysfunction is a main clinical manifestation of Alzheimer's disease (AD). Previous research has found a correlation between elevated orexin level and the progression of AD. Orexin-A treatment has been shown to increase amyloid beta protein (A beta) deposition and worsen spatial memory impairment in mice. Dual orexin receptor (OXR) antagonist has been found to affect A beta level and cognitive dysfunction in AD, but the effects of OX1R or OX2R alone have not been reported. This study investigates the role of OX1R in AD cognitive dysfunction and its possible mechanism.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Cell Biology
Fei Yan, Ju Liu, Mei-Xiang Chen, Ying Zhang, Sheng-Jiao Wei, Hai Jin, Jing Nie, Xiao-Long Fu, Jing-Shan Shi, Shao-Yu Zhou, Feng Jin
Summary: Icariin improves learning and memory impairments in an Alzheimer's disease mouse model by regulating brain insulin signaling and glucose transporters.
NEURAL REGENERATION RESEARCH
(2023)
Article
Clinical Neurology
You-Na Jang, HoChung Jang, Gyu Hyun Kim, Jeong-Eun Noh, Keun-A Chang, Kea Joo Lee
Summary: Elevated levels of RAPGEF2 mediate A beta oligomer-induced synaptic and cognitive impairments in AD, suggesting that early intervention targeting RAPGEF2 expression may be beneficial in preventing early synaptic pathology and memory loss in AD.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2021)
Article
Plant Sciences
Yunfeng Zhou, Dongmei Luo, Junzhuo Shi, Xiaojia Yang, Wangjun Xu, Weiping Gao, Yukun Guo, Qian Zhao, Xinmei Xie, Yangyang He, Guanhua Du, Xiaobin Pang
Summary: This study aimed to investigate the improvement of loganin on cognitive impairment in 3x Tg-AD mice and reveal the potential mechanism. The results showed that loganin significantly mitigated the learning and memory deficit and amyloid beta-protein (Aβ) deposition, and recovered synaptic ultrastructure in 3x Tg-AD mice. Additionally, loganin enhanced mitophagy and mitochondrial function through promoting OPTN-mediated mitophagy. These findings suggest that loganin may be a potential drug candidate for AD therapy.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Neurosciences
Doris Lambracht-Washington, Min Fu, Linda S. Hynan, Roger N. Rosenberg
Summary: DNA Aβ42 immunization in 3xTg-AD mice showed reduced amyloid and tau pathology, improved nest building activity, and increased survival rate. The upregulated genes involved in inflammatory pathways in AD mice were downregulated after immunization, while the expression of genes related to neuronal pathways were restored to wild-type levels in immunized mice. The complex immune response after DNA Aβ42 immunization suggests a move towards disease prevention beyond the amyloid hypothesis.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Donna J. Cross, Bertrand R. Huber, Michael A. Silverman, Marcella M. Cline, Trevor B. Gill, Chloe G. Cross, David G. Cook, Satoshi Minoshima
Summary: Intranasally administered microtubule-stabilizing drugs, specifically paclitaxel, have shown promise in altering the phenotypic progression of Alzheimer's disease in 3xTg-AD mice. These drugs can increase axonal transport rates, reduce phospho-tau containing neurons, improve performance in behavioral tests, and decrease anxiety-related behaviors.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Shuangxue Han, Zhijun He, Xia Hu, Xiaoqian Li, Kaixin Zheng, Yingying Huang, Peng Xiao, Qingguo Xie, Jiazuan Ni, Qiong Liu
Summary: This study demonstrates the close relationship between the activation of NLRP3 inflammasome and the reduction of cerebral glucose metabolism in Alzheimer's disease. By inhibiting NLRP3 inflammasome activation, the cerebral glucose metabolism in AD mice can be restored, leading to improvements in pathology and cognitive function.
Article
Medicine, Research & Experimental
A. Kubis-Kubiak, B. Wiatrak, A. Piwowar
Summary: Glucose metabolism declines in neurodegenerative disorders and is related to increased insulin concentrations. The S100 family proteins may play a crucial role in regulating metabolic disturbances in the brain.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Geriatrics & Gerontology
Yi-Ying Li, Kai-Yue Yu, Yu-Jia Cui, Zhao-Jun Wang, Hong-Yan Cai, Ji-Min Cao, Mei-Na Wu
Summary: In this study, the effects of exogenous orexin-A (OXA) on cognitive deficits, synaptic plasticity, A,B levels, tau hyperphosphorylation, BACE1 and NEP expression, and circadian locomotor rhythm were evaluated in 3xTg-AD mice. The results showed that OXA worsened memory impairments and circadian rhythm disturbance, exacerbated hippocampal LTP depression, and increased A,B and tau pathologies by affecting BACE1 and NEP expression. OXA aggravates cognitive deficits and hippocampal synaptic plasticity impairment in 3xTg-AD mice by increasing A,B production and decreasing A,B clearance through disruption of the circadian rhythm and sleep-wake cycle.
NEUROBIOLOGY OF AGING
(2023)
Article
Neurosciences
Longfei Li, Jin Miao, Yanli Jiang, Chun-Ling Dai, Khalid Iqbal, Fei Liu, Dandan Chu
Summary: Tau immunotherapy, specifically targeting the microtubule-binding domain, shows promise in reducing tau pathology and improving cognitive function in Alzheimer's disease. In vitro and in vivo studies demonstrate that antibody 77G7 effectively clears tau and reduces tau hyperphosphorylation, offering a novel therapeutic opportunity for AD and related tauopathies.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Dominic I. Javonillo, Kristine M. Tran, Jimmy Phan, Edna Hingco, Enikoe A. Kramar, Celia da Cunha, Stefania Forner, Shimako Kawauchi, Giedre Milinkeviciute, Angela Gomez-Arboledas, Jonathan Neumann, Crystal E. Banh, Michelle Huynh, Dina P. Matheos, Narges Rezaie, Joshua A. Alcantara, Ali Mortazavi, Marcelo A. Wood, Andrea J. Tenner, Grant R. MacGregor, Kim N. Green, Frank M. LaFerla
Summary: Animal models are important for studying disease mechanisms and potential treatments, but the availability of numerous animal models presents challenges for Alzheimer's disease (AD) researchers. In this study, the 3xTg-AD mouse model was analyzed to understand the specific pathologies that develop at different ages and to comment on changes since its development 20 years ago. The study also compared the 3xTg-AD model with the 5xFAD model and found that plasma NfL is influenced by plaque burden. The results are freely available for researchers and demonstrate the usefulness of a standardized characterization pipeline for investigating and comparing different AD models.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Hao Fang, Guo Zhou, Qingli Li, Haichao Wang, Xiaobin Pang, Qing Xu, Yunzhou Yu
Summary: The novel recombinant chimeric vaccine showed significant immunogenicity and neuroprotective effects in AD mice, making it a promising candidate for the prophylaxis of Alzheimer's disease.
CURRENT MOLECULAR MEDICINE
(2021)
Article
Neurosciences
Kelly Ceyzeriat, Benjamin B. Tournier, Philippe Millet, Giovanna Dipasquale, Nikolaos Koutsouvelis, Giovanni B. Frisoni, Valentina Garibotto, Thomas Zilli
Summary: This study found that low-dose radiation therapy (LD-RT) reduced amyloid load and possibly neuroinflammation markers in early-stage Alzheimer's disease, but did not impact tauopathy.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Multidisciplinary Sciences
Yesica Gloria, Kelly Ceyzeriat, Stergios Tsartsalis, Philippe Millet, Benjamin B. Tournier
Summary: This study identified early dopaminergic dysfunction in a mouse model of AD, suggesting potential consequences for behavior and cognitive function, and providing insights into future therapeutic strategies.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Luis Alfonso Gonzalez-Molina, Juan Villar-Vesga, Julian Henao-Restrepo, Andres Villegas, Francisco Lopera, Gloria Patricia Cardona-Gomez, Rafael Posada-Duque
Summary: Research indicates that EVs released by astrocytes in Alzheimer's disease (AD) affect neuroglial and vascular components, leading to cell death and neurotoxicity.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)